A5037293448- Assisted Reproductive Technology and Twin Pregnancy
- Systemic Sclerosis and Related Diseases
- Pregnancy and preeclampsia studies
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Birth, Development, and Health
- Ovarian function and disorders
- Blood properties and coagulation
- Folate and B Vitamins Research
- Hormonal Regulation and Hypertension
- Venous Thromboembolism Diagnosis and Management
- Endometriosis Research and Treatment
- Atrial Fibrillation Management and Outcomes
- Renin-Angiotensin System Studies
- Blood Coagulation and Thrombosis Mechanisms
- Lipoproteins and Cardiovascular Health
- Antiplatelet Therapy and Cardiovascular Diseases
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cardiac electrophysiology and arrhythmias
- Cardiovascular Issues in Pregnancy
- Reproductive Health and Technologies
- Reproductive Health and Contraception
- Cardiovascular Effects of Exercise
- Connective Tissue Growth Factor Research
- Prostate Cancer Treatment and Research
- Nitric Oxide and Endothelin Effects
Azienda Ospedaliero-Universitaria Careggi
2009-2024
University of Florence
2010-2023
Florence (Netherlands)
1999-2012
Background: Endometriosis is a chronic and inflammatory disease associated with pelvic pain. Dietary changes may be therapeutic for processes, reducing visceral input. The aim was to evaluate the role of dietary according Mediterranean Diet (MD) on pain perception in endometriosis their relationship oxidative stress. Methods: this prospective study, we included 35 women. At baseline (T0) after 3 (T1) 6 (T2) months from start diet, investigated intensity VAS (Visual Analogue Scale, 0 10),...
Data from literature report that angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism affects the recurrence of preeclampsia and low-molecular-weight heparin (LMWH) prevents adverse outcomes in thrombophilic women. We investigated effect LMWH on pregnancy outcome, maternal blood pressure values, uteroplacental flow ACE DD nonthrombophilic women with history preeclampsia. Eighty were randomized 2 groups: 41 treated dalteparin 5000 IU/day 39 untreated (control group)....
Background: Accelerated atherosclerosis in patients with endometriosis has been hypothesised, and lifestyle improvement might control cardiovascular risk. We explored cardiometabolic markers oxidative stress evaluated the effects of Mediterranean Diet (MD) modulating these markers. Methods: In this prospective study, we included 35 women endometriosis. At baseline (T0) after 3 (T1) 6 (T2) months from start diet, investigated parameters, stress. Results: After a 3-month intervention MD,...
Polymorphisms within renin angiotensin system genes have been investigated as risk factors for coronary artery disease in different populations with contradicting results. The aim of this study was to investigate the genotype distribution and allele frequencies ACE, AT1R AGT gene polymorphisms their synergistic effects on an Italian population. METHODS AND RESULTDS: In were 205 consecutive patients 209 controls. These analysed by polymerase chain reaction (PCR) restriction fragment length...
Mink protein, a beta-subunit of I(ks) potassium channels modulate cardiac cellular electrophysiology, and experimental data demonstrated that NO is involved in vagal activity the inhibition sympathetic activity. We evaluated role eNOS -786T>C, 894G>T, 4a/4b minK S38G polymorphisms as predisposing factors to non-valvular atrial fibrillation (NVAF).We studied 331 consecutive patients with documented NVAF 441 control subjects, comparable for age gender. A significant difference allele...
GENSINI, F., et al. ; Angiotensin‐Converting Enzyme and Endothelial Nitric Oxide Synthase Polymorphisms in Patients with Atrial Fibrillation. Experimental studies have shown a significant increase angiotensin‐converting enzyme (ACE) expression atrial tissue of AF patients. ACE regulates the synthesis endothelial nitric oxide (NO), which modulates autonomic nervous activity involved development AF. The aim study was to evaluate prevalence insertion/deletion NO synthase (eNOS) T‐786C, G894T,...
Summary Mild hyperhomocysteinemia was found to be related venous thrombosis, cerebrovascular and coronary artery disease (CAD). Some recent studies suggested that a mutation in the gene encoding for 5-10 methylenetetrahydrofolate reductase (MTHFR), due transition C→ at nucleotide 677, is genetic risk factor vascular disease. However, several further could not confirm this association. We investigated 84 patients with CAD who underwent percutaneous transluminal angioplasty (PTCA) 106 healthy...
The UPAR gene encodes a pleiotropic receptor (urokinase-type plasminogen activator [uPAR]) involved in fibrosis, immunity, angiogenesis, and vascular remodeling. Previous studies have implicated uPAR systemic sclerosis (SSc) vasculopathy impaired angiogenesis. We undertook this study to investigate whether promoter polymorphisms might be associated with SSc phenotypes the European Caucasian population.We studied total population of 1,339 individuals. Italian discovery cohort comprised 388...
Objective. Systemic sclerosis (SSc) is characterized by microvascular and macrovascular alterations. The D allele of the ACE I/D polymorphism known to be associated with an increased incidence atherosclerosis has been recently proposed as risk SSc. This study evaluates relationship between intima-media thickness (IMT), ankle-brachial pressure measurements (ABPI) in SSc patients. Methods. According presence (analysed PCR), 53 patients (47 females 6 males; median age was 60.4 ± 10.68 yrs;...
Pre-eclampsia is associated with vascular endothelial dysfunction, adverse pregnancy outcome and cardiovascular disease in later life. An inadequate nitric oxide availability related to polymorphisms the synthase gene (eNOS) might predispose disease.We investigated role of eNOS T-786C, G894T 4a4b predisposing both pre-eclampsia recurrence negative events, per se presence angiotensin-converting enzyme (ACE) DD genotype, their influence on maternal-fetal flow 106 non-thrombophilic women a...
Objective. To investigate the possible implication of matrix metalloproteinase-12 ( MMP-12 ) gene in genetic predisposition to systemic sclerosis (SSc) susceptibility and clinical phenotype. Methods. The rs2276109 A/G functional polymorphism was selected as a marker genotyped by polymerase chain reaction-restriction fragment length assay 513 unrelated subjects Italian white ancestry: 250 patients with SSc [146 limited cutaneous (lcSSc), 104 diffuse (dcSSc)] 263 healthy individuals. Results....
The relationship between endometriosis and subclinical atherosclerosis represents an emerging topic in women's health, as women with are at higher risk of cardiovascular disease later life. We investigated metabolic parameters indirect endothelial markers related to atherosclerosis, suffering from stage III/IV compared without endometriosis. study population comprised 643 women: 92 (14.3%) 551 (85.7%) By analyzing biohumoral we observed a significant increased total cholesterol (p = 0.01),...
The homocysteine pathway in the preconception period should be evaluated to highlight micronutrient deficiencies and warrants optimal multivitamin supplementation, before Assisted Reproduction, as care. We conducted a retrospective study aimed at investigating role of vitamin B complex (5-methyltetrahydrofolate, B12, B6) supplement use compared with only folic acid use, relation clinical pregnancy live birth infertile women undergoing homologous ART. investigated 269 Caucasian referred...
Objective: To investigate the possible implication of SDF1 -3′ polymorphism in systemic sclerosis (SSc) susceptibility or clinical phenotype, both. Methods: 150 patients with SSc and controls were enrolled. Skin involvement, autoantibodies, interstitial lung disease, pulmonary arterial hypertension (PAH), scleroderma renal crisis, past and/or current skin ulcers assessed. Genotyping was performed by PCR-RFLP. Results: Genotype distribution allele frequency similar controls. -3′A -3′GA/AA...
To evaluate the role of single-nucleotide polymorphism (SNP) at position -670 in FAS gene promoter (FAS-670G>A) influencing susceptibility, clinical features and severity systemic sclerosis (SSc).350 white Italian SSc patients (259 with limited cutaneous (lcSSc) 91 diffuse (dcSSc)) 232 healthy individuals were studied. Patients assessed for presence autoantibodies (anticentromere, anti-topoisomerase I (anti-Scl-70) antibodies), interstitial lung disease (ILD), pulmonary arterial hypertension...
Endometriosis (EM), a chronic inflammatory condition predominantly affecting women of reproductive age, has been linked to an elevated risk thrombosis, though its underlying molecular mechanisms remain incompletely understood. In this case-control study, involving 71 EM patients and matched controls, we explored the structural functional changes in fibrinogen their potential role thrombosis. Key oxidative stress markers, such as reactive oxygen species (ROS) levels blood lymphocytes,...