A5016498323- Connective tissue disorders research
- Aortic Disease and Treatment Approaches
- Blood Coagulation and Thrombosis Mechanisms
- Folate and B Vitamins Research
- Immune Response and Inflammation
- Cardiac Valve Diseases and Treatments
- Venous Thromboembolism Diagnosis and Management
- Antiplatelet Therapy and Cardiovascular Diseases
- Acute Myocardial Infarction Research
- Protease and Inhibitor Mechanisms
- Heparin-Induced Thrombocytopenia and Thrombosis
- Head and Neck Cancer Studies
- Metabolism and Genetic Disorders
- Platelet Disorders and Treatments
- Chemokine receptors and signaling
- Aortic aneurysm repair treatments
- Blood properties and coagulation
- Cell Adhesion Molecules Research
- Peroxisome Proliferator-Activated Receptors
- Pregnancy and preeclampsia studies
- Atherosclerosis and Cardiovascular Diseases
- Proteoglycans and glycosaminoglycans research
- Atrial Fibrillation Management and Outcomes
- Hemophilia Treatment and Research
- Cardiovascular Function and Risk Factors
University of Florence
2008-2023
Azienda Ospedaliero-Universitaria Careggi
2007-2023
University of Rome Tor Vergata
1997-2018
Florence (Netherlands)
1999-2007
Medico
2002
Medica (Italy)
1992
BACKGROUND Blood clotting activation is an important component of the inflammatory response; outbursts unstable angina are usually associated with increased thrombin formation and coronary mural thrombosis. METHODS AND RESULTS To investigate 1) whether monocyte responsible for enhanced during bursts 2) what mechanism(s) might be activation, we studied patients (n = 31), stable effort 23), left endoventricular thrombosis 8), control subjects 44), measuring plasma fibrinopeptide A (FPA) levels...
Bicuspid aortic valve (BAV) is the most frequent congenital heart disease with involvement in thoracic dilatation, aneurysm and dissection. Although BAV Marfan syndrome (MFS) share some clinical features, MFS patients display mutations FBN1, gene encoding fibrillin-1, genetic background of isolated poorly defined. Ten consecutive [8 men, age range 24–42 years] without were clinically characterized. phenotype function, together evaluation morphology, comprehensively assessed by Doppler...
Background: Accelerated atherosclerosis in patients with endometriosis has been hypothesised, and lifestyle improvement might control cardiovascular risk. We explored cardiometabolic markers oxidative stress evaluated the effects of Mediterranean Diet (MD) modulating these markers. Methods: In this prospective study, we included 35 women endometriosis. At baseline (T0) after 3 (T1) 6 (T2) months from start diet, investigated parameters, stress. Results: After a 3-month intervention MD,...
Summary A difference in the prevalence of venous thromboembolism (TE) major human groups has been described and an uneven distribution FV Leiden mutation over world recently reported. We investigated 584 apparently healthy sub#jects mostly from populations different those previously investi#gated: 170 Europeans (Spanish, Italians), 101 sub-saharan Africans (Fon, Bariba, Berba, Dendi), 115 Asians (Indonesians, Chinese, Tharus), 57 Amerindians (Cayapa), 84 Afroamericans (Rio Cayapa, Viche),...
Emicizumab is a humanized recombinant bispecific antibody, bridging together activated factor IX (FIXa) and X (FX), thus mimicking the activity of FVIII in vivo. designed for long-term prophylaxis patients with severe hemophilia A without inhibitors. This approach provides constant protection, significant reduction bleeding rate improved quality life. However, protection provided by emicizumab not absolute, clotting concentrates (FVIII, rFVIIa, aPCC) may be necessary post-traumatic or...
Summary Elevated plasma levels of tissue factor (TF) and pathway inhibitor (TFPI) large amounts monocyte procoagulant activity (PCA) have been documented in unstable angina (UA) patients. In vitro experiments heparin is able to blunt TF production by inhibiting cytokine gene expression stimulated cells after vivo administration it reduces adverse ischemic outcomes UA TFPI PCA investigated 28 refractory patients before during anticoagulant subcutaneous (thrice daily weight- PTT-adjusted for 3...
Fibrillin‐1 gene ( FBN1 ) mutations cause Marfan syndrome (MFS), an inherited connective tissue disorder with autosomal dominant transmission. Major clinical manifestations affect cardiovascular and skeletal apparatuses ocular central nervous systems. We analyzed in 99 patients referred to our Center for Syndrome Related Disorders (University of Florence, Italy): 85 were affected by MFS 14 other fibrillinopathies type I. identified 80 patients. Among the 77 different mutational events, 46...
In addition to its well-understood anticoagulant activity, heparin is known modulate a variety of biological functions including immunologic responses. order investigate whether influences the humoral immunity by interacting with cellular elements and affecting gene expression in blood circulating cells. we studied effect on IL-1beta, IL-6 TNFalpha mRNAs human lipopolysaccharide-(LPS)- or interferon-gamma(IFN-gamma)-stimulated mononuclear The study mRNA was carried out an initial PCR...
Marfan syndrome (MFS) is a multisystemic disease associated with mutations in the fibrillin‐1 gene. Most of reported are missense substitutions mainly affecting epidermal growth factor (EGF)‐like protein domain structure and calcium‐binding (cb) site. The aim our study was to investigate correlation between frameshift clinical phenotype patients affected by MFS. In 48 out 66 pathogenetic mutation found. We detected novel causing premature termination codon exons 19, 37, 40 41 four Italian...
Head-and-neck cancer (HNC) patients have a high risk of developing second primary tumors the upper aerodigestive tract, main cause death. Although roles tobacco and diet in multiple head-and-neck carcinogenesis been thoroughly investigated, little is known about individual genetic susceptibility factors involved this process. Genomic instability, reflecting propensity genome to acquire alterations, could be considered driving force behind carcinogenesis. Mutation p53 tumor-suppressor gene...