A5025633228- Urologic and reproductive health conditions
- Cassava research and cyanide
- Prostate Cancer Treatment and Research
- Prostate Cancer Diagnosis and Treatment
- Colorectal Cancer Treatments and Studies
- Biliary and Gastrointestinal Fistulas
- Thyroid Cancer Diagnosis and Treatment
- Autoimmune Bullous Skin Diseases
- Tumors and Oncological Cases
- Liver Disease Diagnosis and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer and Skin Lesions
- Poisoning and overdose treatments
- Adrenal and Paraganglionic Tumors
- Soft tissue tumor case studies
- Proteoglycans and glycosaminoglycans research
- Neurofibromatosis and Schwannoma Cases
- Prenatal Substance Exposure Effects
- Neuroblastoma Research and Treatments
- Urological Disorders and Treatments
- Systemic Sclerosis and Related Diseases
- Neuroendocrine Tumor Research Advances
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Corneal Surgery and Treatments
- Metastasis and carcinoma case studies
Université de Poitiers
2007-2023
Inserm
1999-2022
Sorbonne Université
2006-2022
Hôpital Tenon
2022
Centre Hospitalier Universitaire de Grenoble
2019
Centre Hospitalier Universitaire de Poitiers
2008-2018
Biotherapy of Genetic Diseases, Inflammatory Disorders and Cancers
2011-2016
Matrix Research (United States)
2016
Centre Jean Bernard
1991-2015
Laboratoire de Génétique Cellulaire
1993-2014
We attempted to identify morphological parameters of benign prostatic hyperplastic inflammation that correlate with pre-biopsy prostate specific antigen (PSA) concentrations.Patients undergoing biopsy at our department were prospectively studied between January 1995 and 1996. preoperative blood 24-hour urine samples measured for PSA. Biopsy harboring exclusively tissue graded on a 4-point scale (0-no inflammatory cells, 1-scattered cell infiltrate, 2-nonconfluent lymphoid nodules 3-large...
Background Aldosterone producing lesions are a common cause of hypertension, but genetic alterations for tumorigenesis have been unclear. Recently, either two recurrent somatic missense mutations (G151R or L168R) was found in the potassium channel KCNJ5 gene aldosterone adenomas. These alter selectivity filter and result Na+ conductance cell depolarization, stimulating production proliferation. Because similar mutation occurs Mendelian form primary aldosteronism, these appear to be...
Precise diagnosis of low and high grades brain tumors permits determining therapeutical strategies. So far, prognosis gliomas were based on histological genetic criteria which need being completed by a panel molecular markers. Highly distributed in brain, gap junction proteins, connexins, could be considered as markers glioma progression previous studies indicated that expression connexin type, connexin43 (Cx43), is inversely correlated to tumor grading. However, this assumption was weakened...
Our study aimed to construct and evaluate functions called "classifiers", produced by supervised machine learning techniques, in order categorize automatically pathology reports using solely their content.Patients from the Poitou-Charentes Cancer Registry having at least one report a single non-metastatic invasive neoplasm were included. A descriptor weighting function accounting for distribution of terms among targeted classes was developed compared classic methods based on inverse document...
Phosphates are encountered as the main components in about 15% of urinary calculi. Except for struvite, no specific correlations have been found between crystalline phase phosphates and cause nephrolithiasis.The relationship aetiological factors phases or carbonate rate calcium phosphate stones were assessed.From a series 1148 calculi, we investigated composition factors.Carbapatite was most frequent (74.0%). It associated with many possible causes, including hypercalciuria, hypocitraturia,...
Gliomas are characterised by local infiltration, migration of tumour cells across long distances and sustained angiogenesis; therefore, proteins involved in these processes most likely important. Such candidates semaphorins axon guidance cell migration. In addition, regulate progression angiogenesis. For signalling, class-4 bind directly to plexins, whereas class-3 require additional neuropilin (NRP) receptors that also VEGF(165). The anti-angiogenic activity can be explained competition...
The director of a laboratory has to be sure give out reliable results for routine tests on automatic analysers regardless the clinical context. However, he may find hyperbilirubinaemia in some circumstances, parenteral nutrition causing turbidity others, and haemolysis occurring if sampling is difficult. For this reason, Commission Instrumentation Société Française de Biologie Clinique (SFBC) (president Alain Feuillu) decided look into "visible" interferences--bilirubin, turbidity--and their...
Cyanide determination in whole blood can be performed by spectrophotometry after using diffusion coupled with coloration hydroxocobalamin a Conway dish. The technique may accelerated the use of heating sheet at 45 degrees C. method proved to specific, sensitive, and fast, thus permitting measurements emergency situations.
Abstract Syndecans are transmembrane heparan sulfate proteoglycans controlling cell adhesion, migration, and proliferation. We previously showed that syndecan-2 is involved in the control of apoptosis cultured osteosarcoma cells. These data led us to hypothesis may play a role apoptotic signaling bone tumors. immunohistochemically analyzed tissue sections from biopsies 21 patients with well-characterized osteosarcoma. tissues expressed low levels compared osteoblasts osteocytes normal bone....
Abstract The aim of this study was to determine the frequency EGFR , KRAS BRAF and HER ‐ 2 mutations in brain metastases from non‐small cell lung carcinomas ( BM NSCLC ). A total 77 samples were included 19 breast, kidney, colorectal tumors also studied as controls. These collected patients followed between 2008 2011 at Poitiers Nice University Hospitals France. frequencies 2.6, 38.5, 0, 0% respectively. incidence mutation significantly higher female younger P < 0.05). No four genes found...
Objective: Hydroxocobalamin has been proposed as a cyanide antidote. Little is known, however, about its pharmacokinetics in human poisoning. Methods: We prospectively studied the of hydroxocobalamin 11 smoke inhalation victims whom all but one had objective evidence exposure. Serum levels were followed from just before drug administration to six days after single 5 g dose hydroxocobalamin. Results: The results (mean ± standard error) suggest two compartment model. Distribution half-life on...
TSH, via its G-protein-coupled receptor, activates cell growth of both benign and malignant thyroid tumors. receptors (GR) kinase 2 (GRK2) has been reported to regulate the TSH receptor but role in cancer is unknown. To determine a possible function for GRK2 process cancers, we analysed expression normal tumoral tissues studied line proliferation after overexpression. Thirty one tissues, including 16 non-medullary cancers 15 adjacent were by immunohistochemistry. Five paired also western...
Abstract Wound healing is a complex physiological process that repairs skin lesion and produces fibrous tissue. In some cases, this can lead to hypertrophic scars (HS) or keloid (KS), for which the pathophysiology remains poorly understood. Previous studies have reported presence of oncostatin M (OSM) during wound process; however, role OSM in pathological scarring be precisely elucidated. This study aims analyse involvement process. It was conducted with 18 patients, including 9 patients...
// Marie Simonneau 1 , Eric Frouin 1, 2 Vincent Huguier Cynthia Jermidi Jean François Jégou Julie Godet Anne Barra Isabelle Paris Pierre Levillain Sevda Cordier-Dirikoc 3 Nathalie Pedretti Xavier Bernard Claude Lecron Franck Morel and Laure Favot LITEC, Université de Poitiers, France CHU Bioalternatives, Gençay, Correspondence to: Favot, email: laure.favot@univ-poitiers.fr Keywords: oncostatin M; cytokine; skin cancer; tumor microenvironment; immunotherapy Received: July 27, 2018 Accepted:...
Abstract Background Basal calcitonin measurement is routinely performed in patients with a thyroid nodule to detect medullary carcinoma. However, increased does not always correlate The aim of this study was analyse levels without carcinoma and find out whether absence can be predicted certainty. Methods From 1992 2003, 5018 nodules underwent surgery. A retrospective analysis preoperative 67 these performed. Results Pathology revealed 16 (group I), micromedullary 13 II) no 38 III). In group...
The 16q23 locus has been recently suggested in both breast and prostate cancer to contain a gene involved disease progression. antiestrogen resistance 1 (BCAR1) gene, located at 16q23, contributes many cellular processes including migration survival, interacts vitro with the growth factor receptor EGFR metastasis suppressor KAI1.BCAR1, EGFR, KAI1 expression was studied by immunohistochemistry on tissue microarray containing 100 localized cancers (LPC), 15 hormone refractory (HRPC), lymph...