A5100434784- Genetic factors in colorectal cancer
- Cancer Genomics and Diagnostics
- Colorectal Cancer Screening and Detection
- DNA Repair Mechanisms
- Colorectal Cancer Treatments and Studies
- RNA Research and Splicing
- BRCA gene mutations in cancer
- RNA modifications and cancer
- PI3K/AKT/mTOR signaling in cancer
- Sarcoma Diagnosis and Treatment
- Cancer-related Molecular Pathways
- Digestive system and related health
- Gastrointestinal Tumor Research and Treatment
- Neurofibromatosis and Schwannoma Cases
- HER2/EGFR in Cancer Research
- PARP inhibition in cancer therapy
- Cancer Diagnosis and Treatment
- Cancer-related gene regulation
- Ferroptosis and cancer prognosis
- Cancer Immunotherapy and Biomarkers
- Ovarian cancer diagnosis and treatment
- Advanced Breast Cancer Therapies
- Lung Cancer Treatments and Mutations
- Colorectal and Anal Carcinomas
- Multiple and Secondary Primary Cancers
Centre Léon Bérard
2015-2024
Hospices Civils de Lyon
2014-2024
Centre de Recherche en Cancérologie de Lyon
2003-2024
Shaoxing People's Hospital
2024
Inserm
1997-2024
Fudan University Shanghai Cancer Center
2024
Shandong First Medical University
2023
Affiliated Hospital of Taishan Medical University
2023
Shanghai First People's Hospital
2021
Shanghai Jiao Tong University
2021
Current treatments for diabetic ulcers (DUs) remain unsatisfactory due to the risk of bacterial infection and impaired angiogenesis during healing process. The increased degradation polyubiquitinated hypoxia-inducible factor-1α (HIF-1α) compromises wound efficacy. Therefore, maintenance HIF-1α protein stability might help treat DU. Nitric oxide (NO) is an intrinsic biological messenger that functions as a ubiquitination flow repressor antibacterial agent; however, its clinical application in...
Numerous unclassified variants (UVs) have been found in the mismatch repair genes MLH1 and MSH2 involved hereditary nonpolyposis colorectal cancer (HNPCC or Lynch syndrome). Some of these may an effect on pre-mRNA splicing, either by altering degenerate positions splice site sequences affecting intronic exonic splicing regulatory such as enhancers (ESEs). In order to determine consequences UVs we used a functional assay exon inclusion. For each variant, mutant wild-type exons be tested were...
BRCA1/2 are cancer predisposition genes involved in hereditary breast and ovarian (HBOC). Mutation carriers display an increased sensitivity to inhibitors of poly(ADP‐ribose) polymerase (PARP). Despite a number small‐size hospital‐based studies being previously reported, there is not yet, our knowledge, precise data mutations among Chinese patients. We performed multicenter cohort study including 916 unselected consecutive epithelial (EOC) patients from eastern China screen for using the...
Since the first report by our group in 1999, more than 20 unrelated biallelic mutations DNA mismatch repair genes (MMR) have been identified. In present report, we describe two novel cases: one carrying compound heterozygous MSH6 gene; and other, PMS2 gene. Interestingly, inactivation of allele was likely caused gene conversion. Although conversion has suggested to be a mutation mechanism underlying inactivation, this is its involvement pathogenic mutation. The clinical features carriers...
Hereditary nonpolyposis colorectal cancer (HNPCC) is an autosomal dominant syndrome caused by germline mutations of the mismatch repair (MMR) genes. Only a few studies have taken into account selection families tested for these in estimating (CRC) risk carriers. They found much lower estimates CRC risks than previous ones, but lacked precision despite large number families. The aim this study was to evaluate efficiency 'genotype restricted likelihood' (GRL) method that provides unbiased...
The PI3K/AKT/mTOR pathway alterations have been shown to play significant roles in the development, progression, and metastatic spread of breast cancer. Furthermore, they implicated process drug resistance, especially endocrinal therapies. In this study, we aimed define correlation between PI3K mutations expression phosphorylated forms different downstream molecules women with estrogen receptor (ER)-positive, human epidermal growth factor 2-negative (luminal) early cancer treated at Cairo...
Conventional treatment for locally advanced rectal cancer usually combines neoadjuvant radiochemotherapy and surgery. Until recently, there have been limited predictive factors (clinical or biological) tumor response to conventional treatment. KRAS, BRAF PIK3CA mutations are commonly found in colon cancers. In this study, we aimed determine the mutation frequencies of establish whether such may be used as prognostic and/or patients. We retrospectively reviewed clinical biological data 98...