A5017149105- Pain Mechanisms and Treatments
- Neuropeptides and Animal Physiology
- Pain Management and Placebo Effect
- Receptor Mechanisms and Signaling
- Pharmacological Receptor Mechanisms and Effects
- Neuroendocrine regulation and behavior
- Neurotransmitter Receptor Influence on Behavior
- Photoreceptor and optogenetics research
- Neuroscience and Neuropharmacology Research
- Birth, Development, and Health
- Ion Transport and Channel Regulation
- Musculoskeletal pain and rehabilitation
- Functional Brain Connectivity Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Computational Drug Discovery Methods
- Pediatric Pain Management Techniques
- Pancreatic function and diabetes
- Anesthesia and Pain Management
- Cholinesterase and Neurodegenerative Diseases
- Endoplasmic Reticulum Stress and Disease
- Anesthesia and Neurotoxicity Research
- Erythrocyte Function and Pathophysiology
- Ion channel regulation and function
- Electromagnetic Fields and Biological Effects
- Intensive Care Unit Cognitive Disorders
University of North Carolina at Chapel Hill
2022-2025
Université de Montpellier
2021-2024
University of North Carolina Health Care
2024
Inserm
2018-2023
Institute for Neurosciences of Montpellier
2018-2023
Centre National de la Recherche Scientifique
2017-2023
Harvard University
2023
Massachusetts General Hospital
2023
Université de Bordeaux
2023
Bordeaux Population Health
2023
Placebo effects are notable demonstrations of mind-body interactions
Peripheral neuropathic pain (PNP) is a debilitating and intractable chronic disease, for which sensitization of somatosensory neurons present in dorsal root ganglia that project to the spinal cord key physiopathological process. Here, we show hematopoietic cells at nerve injury site express cytokine FL, ligand fms-like tyrosine kinase 3 receptor (FLT3). FLT3 activation by intra-sciatic injection FL sufficient produce hypersensitivity, activate PNP-associated gene expression generate...
Acute pain has been associated with persistent sensitization of nociceptive pathways increasing the risk transition from acute to chronic pain. We demonstrated critical role FLT3- tyrosine kinase receptor, expressed in sensory neurons, chronification after peripheral nerve injury. However, it is unclear whether injury-induced can also promote long-term mood disorders. Here, we evaluated emotional and sensorial components a single (SI) or double paw incision (DI) implication FLT3. DI mice...
Microglia take on an altered morphology during chronic opioid treatment. This morphological change is broadly used to identify the activated microglial state associated with side effects, including tolerance and opioid-induced hyperalgesia (OIH). display similar responses in spinal cord after peripheral nerve injury (PNI). Consistent this observation, functional studies have suggested that microglia by opioids or PNI engage common molecular mechanisms induce hypersensitivity. In article, we...
l-Theanine (or l-γ-N-ethyl-glutamine) is the major amino acid found in Camellia sinensis. It has received much attention because of its pleiotropic physiological and pharmacological activities leading to health benefits humans, especially. We describe here a new, easy, efficient, environmentally friendly chemical synthesis l-theanine l-γ-N-propyl-Gln their corresponding d-isomers. l-Theanine, derivatives obtained so far, exhibited partial coagonistic action at N-methyl-d-aspartate (NMDA)...
Navigating the duality of opioids' potent analgesia and side effects, including tolerance hyperalgesia, is a significant challenge in chronic pain management, often prompting hazardous dose escalation to maintain analgesic effects. The peripheral mu-opioid receptor (MOR) known mediate these contradictory Here, we show that fms-like tyrosine kinase 3 (FLT3) somatosensory neurons drives morphine hyperalgesia male rodent model. We found treatment increases FLT3 MOR co-expression, inhibiting...
The kidneys act as finely tuned sensors to maintain physiological homeostasis. Both sympathetic and sensory nerves modulate kidney function through precise neural control. However, how the are innervated during development support remains elusive. Using light-sheet confocal microscopy, we generated anatomical maps of innervation across development. Kidney commences on embryonic day 13.5 (E13.5) network growth aligns with arterial differentiation. Fibers synapsin I
The neural substrate of pain experience has been described as a dense network connected brain regions. However, the connectivity pattern these regions remains elusive, precluding deeper understanding how emerges from structural connectivity. Here, we employ graph theory to systematically characterize architecture comprehensive network, including both cortical and subcortical areas. This consists 49 nodes denoting pain-related areas, linked by edges representing their relative incoming...
The neural substrate of pain experience has been described as a dense network connected brain regions. However, the connectivity pattern these regions remains elusive, precluding deeper understanding how emerges from structural connectivity. Here, we use graph theory to systematically characterize architecture comprehensive network, including both cortical and subcortical areas. This consists 49 nodes denoting pain-related areas, linked by edges representing their relative incoming outgoing...
<title>Abstract</title> Navigating the duality of opioids' potent analgesia and side effects, including tolerance hyperalgesia, is a significant challenge in chronic pain management, often prompting hazardous dose escalation to maintain analgesic effects. The peripheral mu-opioid receptor (MOR) known mediate these contradictory Here, we show that fms-like tyrosine kinase 3 (FLT3) somatosensory neurons drives morphine hyperalgesia. We found treatment increases FLT3 MOR co-expression,...
Piezo2 is a mechanically activated ion channel expressed in subset of sensory neurons, including the bladder. Our lab has recently mapped innervation developing kidney and found that renal nerve development begins at embryonic day 13.5 (E13.5) tightly aligned with smooth muscle actin (SMA + ) arterial development. However, presence spatiotemporal nerves remains unknown. In current study, we hypothesized would be present early adjacent nephrons these axons innervating could traced back to...
Abstract The kidney functions as a finely tuned sensor to balance body fluid composition and filter out waste through complex coordinated mechanisms. This versatility requires tight neural control, with innervating efferent nerves playing crucial role in regulating blood flow, glomerular filtration rate, water sodium reabsorption, renin release. In turn sensory afferents provide feedback the central nervous system for modulation of cardiovascular function. However, cells targeted by...
Acute pain has been associated with persistent sensitization of nociceptive pathways increasing the risk transition from acute to chronic pain. We demonstrated critical role FLT3- tyrosine kinase receptor, expressed in sensory neurons, chronification after peripheral nerve injury. However, it is unclear whether injury-induced can also promote long-term mood disorders. Here, we evaluated emotional and sensorial components a single (SI) or double paw incision (DI) implication FLT3. DI mice...
Summary The ability to efficiently switch from one defensive strategy another maximizes an animal’s chance of survival. Here, we demonstrate that the selection active behaviors requires coordinated activation dopamine D2 receptor (D2R) signaling within central extended amygdala (EA) comprising nucleus accumbens, oval bed stria terminals and amygdala. We find discriminative learning between predictive non-predictive threat auditory stimuli is unaltered in mice carrying a temporally-controlled...
Abstract Opioid analgesia is counteracted on chronic use by tolerance and hyperalgesia inducing dose escalation life-threatening overdoses. Mu opiate receptors (MOR) expressed in primary sensory neurons were recently found to control hyperalgesia, but the underlying mechanisms remained elusive. Here we show that genetic inactivation of fms -like tyrosine kinase receptor 3 (FLT3) abrogates morphine preventing MOR-induced hyperactivation cAMP signaling pathway subsequent excitatory adaptive...
Abstract In mammals, the ability to optimize and select behavioral strategies is a cardinal conserved psychophysiological feature for maximizing chances of survival. However, neural circuits underlying mechanisms regulating this flexible remain yet unsolved. Here, we demonstrate that such optimization relies on dopamine D2 receptors (D2R) within subcircuit spanning across extended amygdala (EA) tail striatum (TS). Using mouse model carrying temporally controlled deletion D2R defined by WFS1...