A5015767542- Neural dynamics and brain function
- Memory and Neural Mechanisms
- Neuroscience and Neuropharmacology Research
- Receptor Mechanisms and Signaling
- Photoreceptor and optogenetics research
- Neuroendocrine regulation and behavior
- Sleep and Wakefulness Research
- Stress Responses and Cortisol
- Functional Brain Connectivity Studies
- Neurotransmitter Receptor Influence on Behavior
- EEG and Brain-Computer Interfaces
- Gene Regulatory Network Analysis
- Pain Mechanisms and Treatments
- Anesthesia and Neurotoxicity Research
- Nonlinear Dynamics and Pattern Formation
- Genetics and Neurodevelopmental Disorders
- Circadian rhythm and melatonin
- Axon Guidance and Neuronal Signaling
- Endoplasmic Reticulum Stress and Disease
Neurocentre Magendie
2017-2023
Université de Bordeaux
2018-2023
Inserm
2017-2023
Bordeaux Population Health
2022-2023
Institute for Neurosciences of Montpellier
2023
Massachusetts General Hospital
2023
Université Paris Cité
2023
Johns Hopkins University
2023
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2023
Harvard University
2023
In the idling brain, neuronal circuits transition between periods of sustained firing (UP state) and quiescence (DOWN state), a pattern mechanisms which remain unclear. Here we analyzed spontaneous cortical population activity from anesthetized rats found that UP DOWN durations were highly variable rates showed no significant decay during periods. We built network rate model with excitatory (E) inhibitory (I) populations exhibiting novel bistable regime quiescent an inhibition-stabilized...
Survival critically depends on selecting appropriate defensive or exploratory behaviors and is strongly influenced by the surrounding environment. Contextual discrimination a fundamental process that thought to depend prefrontal cortex integrate sensory information from environment regulate adaptive responses threat during uncertainty. However, precise circuits necessary for discriminating previously threatening context neutral remain unknown. Using combination of single-unit recordings...
Key points We confirm that GABA B receptors (GABA ‐Rs) are involved in the termination of Up‐states; their blockade consistently elongates Up‐states. ‐Rs also modulate Down‐states and oscillatory cycle, thus having an impact on slow oscillation rhythm its regularity. The most frequent effect ‐R is elongation subsequent decrease frequency, with increased In a quarter cases, shortened changes independent firing rates Our computer model provides mechanisms for experimentally observed dynamics...
Abstract In the idling brain, neuronal circuits often exhibit transitions between periods of sustained firing (UP state) and quiescence (DOWN state). Although these dynamics occur across multiple areas behavioral conditions, underlying mechanisms remain unclear. Here we analyze spontaneous population activity from somatosensory cortex urethane-anesthetized rats. We find that UP DOWN are variable (i.e. non-rhythmic) rate shows no significant decay during periods. build a network model...
Abstract The value of rewards and punishments – namely, how good or bad they are perceived guides approach avoidance behaviors. Valence refers to the negative positive “sign” state elicited by an event, whereas salience amount attention event attracts, disregarding its valence. While identifying these signals conveys critical information for understanding circuits involved in emotional processing, often confounded due their underlying correlation. Moreover, study neural basis coding has been...
Abstract Slow wave oscillations (SWO) dominate cortical activity during deep sleep, anesthesia and in some brain lesions. SWO consist of Up states or periods interspersed with Down silence. The rhythmicity expressed integrates neuronal connectivity properties the network it is often altered neurological pathological conditions. Different mechanisms have been proposed to drive transitions between states, particular, adaptation contribute Up-to-Down transition. Synaptic inhibition, specially...
SUMMARY Survival critically depends on the memorization of stimuli recurrently predicting pleasant or aversive experiences. Memory strengthening by additional learning is a critical process allowing long-term stabilization learned experience. However, underlying neuronal circuits and mechanisms are still largely unknown. Using combination single unit recordings optogenetic manipulations, we observed that strengthened fear responses following successive episodes led to remapping in population...
Abstract Upon threatening situations, animals exhibit a broad range of behavioral and autonomic responses. As such, crucial adaptive response is the inhibition pain to facilitate relevant defensive behaviors that promote survival. Whereas structures mechanisms involved in fear behavior are well documented, little known about precise neuronal mediating emotional regulation endogenous pain-suppression. Here we used combination behavioral, anatomical, optogenetic, electrophysiological...
Abstract Upon threatening situations, animals exhibit a broad range of behavioral and autonomic responses necessary for survival. Under such conditions, crucial adaptive response is the inhibition pain that would otherwise interfere with defensive responses. Whereas structures mechanisms involved in fear behavior are well documented, little known about precise neuronal mediating emotional regulation endogenous pain-suppression. Here we used combination behavioral, anatomical, optogenetic,...
Summary The ability to efficiently switch from one defensive strategy another maximizes an animal’s chance of survival. Here, we demonstrate that the selection active behaviors requires coordinated activation dopamine D2 receptor (D2R) signaling within central extended amygdala (EA) comprising nucleus accumbens, oval bed stria terminals and amygdala. We find discriminative learning between predictive non-predictive threat auditory stimuli is unaltered in mice carrying a temporally-controlled...
Abstract In mammals, the ability to optimize and select behavioral strategies is a cardinal conserved psychophysiological feature for maximizing chances of survival. However, neural circuits underlying mechanisms regulating this flexible remain yet unsolved. Here, we demonstrate that such optimization relies on dopamine D2 receptors (D2R) within subcircuit spanning across extended amygdala (EA) tail striatum (TS). Using mouse model carrying temporally controlled deletion D2R defined by WFS1...
The medial prefrontal cortex (mPFC) is at the core of numerous psychiatric conditions, including fear and anxiety-related disorders. Whereas an abundance evidence suggests a crucial role mPFC in regulating behaviour, precise this process not yet entirely clear. While studies single-cell level have demonstrated involvement area various aspects processing, such as encoding threat-related cues expression, increasingly prevalent idea systems neuroscience field that populations neurons are, fact,...
SUMMARYSurvival critically depends on the memorization of stimuli recurrently predicting pleasant or aversive experiences. Memory strengthening by additional learning is a critical process allowing long-term stabilization learned experience. However, underlying neuronal circuits and mechanisms are still largely unknown. Using combination single unit recordings optogenetic manipulations, we observed that strengthened fear responses following successive episodes led to remapping in population...