A5085938812- Sleep and Wakefulness Research
- Sleep and related disorders
- Cannabis and Cannabinoid Research
- Memory and Neural Mechanisms
- Circadian rhythm and melatonin
- Stroke Rehabilitation and Recovery
- Spinal Cord Injury Research
- Nicotinic Acetylcholine Receptors Study
- Neurotransmitter Receptor Influence on Behavior
- Cerebral Palsy and Movement Disorders
- Neuroendocrine regulation and behavior
- Receptor Mechanisms and Signaling
- Transcranial Magnetic Stimulation Studies
- Stress Responses and Cortisol
- Neuroscience of respiration and sleep
- Neuroscience and Neuropharmacology Research
- Alzheimer's disease research and treatments
- Neuroscience and Music Perception
- Pharmacological Receptor Mechanisms and Effects
- Endoplasmic Reticulum Stress and Disease
- Neuropeptides and Animal Physiology
- Zebrafish Biomedical Research Applications
- Nerve Injury and Rehabilitation
- Neuroinflammation and Neurodegeneration Mechanisms
- Diverse Music Education Insights
Bellvitge University Hospital
2023-2025
Universitat de Barcelona
2023-2025
Institut d'Investigació Biomédica de Bellvitge
2023-2025
Universitat Pompeu Fabra
2011-2022
Universitat Autònoma de Barcelona
2018-2022
Centro de Investigación Biomédica en Red
2021
Biomedical Research Networking Center on Neurodegenerative Diseases
2021
Institut Guttmann
2020
Inserm
2017
Universidad Francisco de Vitoria
2017
Exposure to traumatic stress can lead fear dysregulation, which has been associated with posttraumatic disorder (PTSD). Previous work showed that a polymorphism in the PACAP-PAC1R (pituitary adenylate cyclase-activating polypeptide) system is PTSD risk women, and PACAP (ADCYAP1)-PAC1R (ADCYAP1R1) are highly expressed hypothalamus. Here, we show female mice subjected acute immobilization (IMO) have extinction impairments related Adcyap1 Adcyap1r1 mRNA upregulation hypothalamus, PACAP-c-Fos...
Electrical enabling motor control (eEmc) through transcutaneous spinal cord stimulation is a non-invasive method that can modify the functional state of sensory-motor system. We hypothesize eEmc delivery, together with hand training, improves function in healthy subjects more than either intervention alone by inducing plastic changes at and cortical levels. Ten voluntary participants were included following three interventions: (i) grip (ii) eEmc, (iii) training. Functional evaluation box...
Orexins are hypothalamic neuropeptides recently involved in the regulation of emotional memory. The basolateral amygdala, an area orchestrating fear memory processes, appears to be modulated by orexin transmission during extinction. However, neuronal types within amygdala this modulation remain elucidated.We used retrograde tracing combined with immunofluorescence techniques mice identify projection neurons and cell subpopulations brain region influenced contextual extinction...
Anxiety and stress disorders are often characterized by an inability to extinguish learned fear responses. Orexins/hypocretins involved in the modulation of aversive memories, dysregulation this system may contribute aetiology anxiety pathological fear. The mechanisms which orexins regulate unknown. Here we investigated role endogenous cannabinoid impaired extinction induced orexin-A (OXA) male mice. selective inhibitor 2-arachidonoylglycerol (2-AG) biosynthesis O7460 abolished deficits OXA....
Electrical enabling motor control (eEmc) through transcutaneous spinal cord stimulation offers promise in improving hand function. However, it is still unknown which stimulus intensity or muscle force level could be better for this improvement. Nine healthy individuals received the following interventions: (i) eEmc intensities at 80%, 90% and 110% of abductor pollicis brevis threshold combined with training consisting 100% handgrip strength; (ii) 50% maximal strength intensity. The...
Background and Purpose Anatomical, biochemical pharmacological evidence suggest the existence of a crosstalk between orexinergic endocannabinoid systems. While orexin receptor 1 (OX receptor) modulates reinforcing properties cannabinoids, participation orexins in acute effects Δ 9 ‐tetrahydrocannabinol (THC) remains unexplored. Experimental Approach We assessed possible role THC‐induced hypolocomotion, hypothermia, antinociception, anxiolytic‐ anxiogenic‐like memory impairment. Selective OX...
Transcriptomics and phosphoproteomics were carried out in the cerebral cortex of B6.Cg-Mapttm1(EGFP)Klt (tau knockout: tau-KO) wild-type (WT) 12 month-old mice to learn about effects tau ablation. Compared with WT mice, tau-KO displayed reduced anxiety-like behavior lower fear expression induced by aversive conditioning, whereas recognition memory remained unaltered. Cortical transcriptomic analysis revealed 69 downregulated 105 upregulated genes corresponding synaptic structures, neuron...
Chronic pain is a debilitating disease that usually comorbid to anxiety and depression. Current treatment approaches mainly rely on analgesics but often neglect emotional aspects. Nonpharmacological interventions, such as listening music, have been incorporated into clinics provide more comprehensive management of chronic pain. However, the underlying mechanisms music-mediated relief are not fully understood.