A5039644626- Neurotransmitter Receptor Influence on Behavior
- Epigenetics and DNA Methylation
- Neuroendocrine regulation and behavior
- MicroRNA in disease regulation
- Genetics and Neurodevelopmental Disorders
- Neuropeptides and Animal Physiology
- Eating Disorders and Behaviors
- Nicotinic Acetylcholine Receptors Study
- Neuroscience and Neuropharmacology Research
- Stress Responses and Cortisol
- Regulation of Appetite and Obesity
Universitat Pompeu Fabra
2020-2022
Abstract Food addiction is linked to obesity and eating disorders characterized by a loss of behavioral control compulsive food intake. Here, using mouse model, we report that the lack cannabinoid type-1 receptor in dorsal telencephalic glutamatergic neurons prevents development addiction-like behavior, which associated with enhanced synaptic excitatory transmission medial prefrontal cortex (mPFC) nucleus accumbens (NAc). In contrast, chemogenetic inhibition neuronal activity mPFC-NAc...
Exposure to traumatic stress can lead fear dysregulation, which has been associated with posttraumatic disorder (PTSD). Previous work showed that a polymorphism in the PACAP-PAC1R (pituitary adenylate cyclase-activating polypeptide) system is PTSD risk women, and PACAP (ADCYAP1)-PAC1R (ADCYAP1R1) are highly expressed hypothalamus. Here, we show female mice subjected acute immobilization (IMO) have extinction impairments related Adcyap1 Adcyap1r1 mRNA upregulation hypothalamus, PACAP-c-Fos...