A5025599568- Memory and Neural Mechanisms
- Neuroscience and Neuropharmacology Research
- Neural dynamics and brain function
- Neuroendocrine regulation and behavior
- Receptor Mechanisms and Signaling
- Stress Responses and Cortisol
- Neuroinflammation and Neurodegeneration Mechanisms
- Sleep and Wakefulness Research
- Photoreceptor and optogenetics research
- Neurotransmitter Receptor Influence on Behavior
- Anesthesia and Neurotoxicity Research
- Neurobiology and Insect Physiology Research
- Circadian rhythm and melatonin
- Nicotinic Acetylcholine Receptors Study
- Photochromic and Fluorescence Chemistry
- Pain Mechanisms and Treatments
- EEG and Brain-Computer Interfaces
- Neurogenesis and neuroplasticity mechanisms
- Zebrafish Biomedical Research Applications
- Intramuscular injections and effects
- Child and Animal Learning Development
- Heart Rate Variability and Autonomic Control
- Advanced Fluorescence Microscopy Techniques
- Intravenous Infusion Technology and Safety
- Endoplasmic Reticulum Stress and Disease
Inserm
2016-2025
Neurocentre Magendie
2016-2025
Université de Bordeaux
2014-2024
Centre National de la Recherche Scientifique
2002-2023
Bordeaux Population Health
2011-2023
Université de Montpellier
2023
Institute for Neurosciences of Montpellier
2023
Harvard University
2023
Massachusetts General Hospital
2023
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2023
In adult animals, fear conditioning induces a permanent memory that is resilient to erasure by extinction. contrast, during early postnatal development, extinction of conditioned leads erasure, suggesting memories are actively protected in adults. We show here this protection conferred extracellular matrix chondroitin sulfate proteoglycans (CSPGs) the amygdala. The organization CSPGs into perineuronal nets (PNNs) coincided with developmental switch resilience. adults, degradation PNNs...
The amygdala has been studied extensively for its critical role in associative fear conditioning animals and humans. Noxious stimuli, such as those used conditioning, are most effective eliciting behavioral responses activation when experienced an unpredictable manner. Here, we show, using a translational approach mice humans, that unpredictability per se without interaction with motivational information is sufficient to induce sustained neural activity the elicit anxiety-like behavior....
Brain-body interactions are thought to be essential in emotions but their physiological basis remains poorly understood. In mice, regular 4 Hz breathing appears during freezing after cue-fear conditioning. Here we show that the olfactory bulb (OB) transmits this rhythm dorsomedial prefrontal cortex (dmPFC) where it organizes neural activity. Reduction of respiratory-related oscillation, via bulbectomy or optogenetic perturbation OB, reduces freezing. Behavioural modelling shows is due a...
Considerable efforts have been made to identify changes of brain synaptic plasticity associated with fear conditioning. However, for both clinical applications and our fundamental understanding memory processes, it appears also necessary investigate related extinction. We previously showed that extinction freezing a tone conditioned stimulus (CS; paired footshock) in mice results sequence depression potentiation efficacy the medial prefrontal cortex (mPFC). These data as well those from...
Abstract Whereas the neuronal substrates underlying acquisition of auditory fear conditioning have been widely studied, and mechanisms mediating extinction remain largely elusive. Previous reports indicate that consolidation depends on mitogen‐activated protein kinase/extracellular‐signal regulated kinase (MAPK/ERK) signalling pathway synthesis in medial prefrontal cortex (mPFC). Based experiments using fear‐potentiated startle paradigm suggesting a role for plasticity basolateral amygdala...
Abstract Extinction of classical fear conditioning is thought to involve activity‐dependent potentiation synaptic transmission in the medial prefrontal cortex (mPFC), resulting inhibition amygdala‐dependent responses. While many studies have addressed mechanisms underlying extinction learning, it unclear what determines whether memory consolidated or spontaneous recovery response occurs. Here we show, using a combined electrophysiological and immunocytochemical approach, that conditioned...
Fear conditioning is a popular model for investigating physiological and cellular mechanisms of memory formation. In this paradigm, footshock either systematically associated to tone (paired conditioning) or pseudorandomly distributed (unpaired conditioning). the former procedure, tone/shock association acquired, whereas in latter context/shock will prevail. Animals with chronically implanted recording electrodes show enhanced amplitude extracellularly recorded field EPSP CA1 pyramidal cells...
Survival critically depends on selecting appropriate defensive or exploratory behaviors and is strongly influenced by the surrounding environment. Contextual discrimination a fundamental process that thought to depend prefrontal cortex integrate sensory information from environment regulate adaptive responses threat during uncertainty. However, precise circuits necessary for discriminating previously threatening context neutral remain unknown. Using combination of single-unit recordings...