A5101697819- Neurotransmitter Receptor Influence on Behavior
- Neuroscience and Neuropharmacology Research
- Receptor Mechanisms and Signaling
- Cannabis and Cannabinoid Research
- Psychedelics and Drug Studies
- Tryptophan and brain disorders
- Nicotinic Acetylcholine Receptors Study
- Forensic Toxicology and Drug Analysis
- Biochemical Analysis and Sensing Techniques
- Neuropeptides and Animal Physiology
- Memory and Neural Mechanisms
- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Genetic Neurodegenerative Diseases
- Diet and metabolism studies
- Attention Deficit Hyperactivity Disorder
- Neuroinflammation and Neurodegeneration Mechanisms
- Psychosomatic Disorders and Their Treatments
- Stress Responses and Cortisol
- Olfactory and Sensory Function Studies
- Neural dynamics and brain function
- Amino Acid Enzymes and Metabolism
- Personality Disorders and Psychopathology
- Mental Health and Psychiatry
- Edible Oils Quality and Analysis
Hospital Del Mar
2015-2025
Municipal Institute for Medical Research
2015-2025
Universitat Pompeu Fabra
2015-2025
Hospital Universitario 12 De Octubre
2025
Hospital del Mar Research Institute
2014-2024
Université de Montréal
2023
Hospital San Pedro de Alcántara
2019
Barcelona Biomedical Research Park
2010-2014
Instituto de Salud Carlos III
2012
Universitat de Barcelona
1999-2005
Activation of cannabinoid CB1 receptors (CB1R) by delta9-tetrahydrocannabinol (THC) produces a variety negative effects with major consequences in cannabis users that constitute important drawbacks for the use cannabinoids as therapeutic agents. For this reason, there is tremendous medical interest harnessing beneficial THC. Behavioral studies carried out mice lacking 5-HT2A (5-HT2AR) revealed remarkable 5-HT2AR-dependent dissociation antinociceptive THC and its detrimental amnesic...
Abstract G protein-coupled receptors (GPCRs) are sophisticated signaling machines able to simultaneously elicit multiple intracellular pathways upon activation. Complete (in)activation of all can be counterproductive for specific therapeutic applications. This is the case serotonin 2 A receptor (5-HT 2A R), a prominent target treatment schizophrenia. In this study, we elucidate complex 5-HT R coupling signature in response different probes, and its physiological consequences by combining...
The involvement of dynorphin on Δ-9-tetrahydrocannabinol (THC) and morphine responses has been investigated by using mice with a targeted inactivation the prodynorphin (<i>Pdyn</i>) gene. Dynorphin-deficient show specific changes in behavioral effects THC, including reduction spinal THC analgesia absence THC-induced conditioned place aversion. In contrast, acute chronic opioid were normal. lack negative motivational demonstrates that this endogenous peptide mediates dysphoric marijuana.
It has been shown previously that the endogenous opioid system may be involved in behavioral effects of nicotine. In present study, participation enkephalins on nicotine responses investigated by using preproenkephalin knock-out mice. Acute nicotine-induced hypolocomotion remained unaffected these contrast, antinociception elicited tail-immersion and hot-plate tests acute administration was reduced mutant animals. The rewarding properties were then place-conditioning paradigm. Nicotine...
Acetylcholine (ACh) is a known modulator of the activity dopaminergic (DAergic) neurons through stimulation nicotinic ACh receptors (nAChRs). Yet, subunit composition and specific location nAChRs involved in DA-mediated locomotion remain to be established vivo . Mice lacking β2 (β2KO) display striking hyperactivity open field, which suggests an imbalance DA neurotransmission. Here, we performed selective gene rescue functional β2*-nAChRs either substantia nigra pars compacta (SNpc) or...
The intricate involvement of the serotonin 5-HT
The present study examined the effects of lesions central nucleus amygdala (CeA) on acquisition a new response with conditioned reinforcement (CR) and its potentiation by intra-accumbens infusions d-amphetamine (1, 3, 10, 20 microg/microl). Rats were trained to associate light-plus-noise compound stimulus availability sucrose solution before receiving both bilateral ibotenic acid CeA cannulas implanted above accumbens. Lesions did not impair performance positively reinforced discriminated...