Abstract Background Insulin resistance (IR) is considered a pivotal risk factor for cardiometabolic diseases, and the triglyceride–glucose index (TyG index) has emerged as reliable surrogate marker of IR. Although several recent studies have shown association TyG with vascular disease, no further investigated role in acute ST-elevation myocardial infarction (STEMI). The objective present study was to evaluate potential predictor prognosis STEMI patients after percutaneous coronary...

Abstract Background Abnormal lipid metabolism poses a risk for prediabetes. However, research on parameters used to predict the of prediabetes is scarce, and significance traditional untraditional remains unexplored in This study aimed comprehensively evaluate association between 12 their diagnostic value. Methods cross-sectional included data from 100,309 Chinese adults with normal baseline blood glucose levels. New onset was outcome concern. Untraditional were derived parameters....

Background Endothelial dysfunction, a hallmark of diabetes, is critical and initiating contributor to the pathogenesis diabetic cardiovascular complications. However, underlying mechanisms are still not fully understood. Ferroptosis newly defined regulated cell death driven by cellular metabolism iron-dependent lipid peroxidation. Although involvement ferroptosis in disease has been shown cancers degenerative diseases, participation endothelial dysfunction remains unclear. Aim To examine...

Contrast-induced acute kidney injury (CI-AKI) causes clinically acquired nephropathy in patients who undergo coronary interventions. Hypoxic to proximal tubular epithelial cells is a pathological mechanism of CI-AKI. Previous studies have shown that hypoxia activates HIF-1α/HE4/NF-κB enhance renal fibrosis, and the SGLT-2 inhibitor luseogliflozin inhibits hypoxia-inducible factor (HIF)-1α expression reduce progression diabetic nephropathy. However, therapeutic effects mechanisms inhibitors...

We investigated the long-term outcome of urethral reconstruction using colonic mucosa grafts for long segment, complex strictures. Another aim was to identify clinical factors impacting outcomes.We retrospectively reviewed records 36 consecutive patients with a mean age 39.8 years (range 17 70) who underwent mucosal graft urethroplasty stricture from October 2000 November 2006. Patients were evaluated postoperatively at scheduled office visits our institution and/or by telephone interview....

Background and Objectives Triglyceride-glucose (TyG) is an emerging vital indicator of insulin resistance associated with increased risk T2DM cardiovascular events. We aimed to explore the TyG index contrast-induced acute kidney injury (CI-AKI) in patients type 2 diabetes who underwent coronary angiology. Methods This study enrolled 928 suspected artery disease angiology or percutaneous intervention Zhongda hospital. Patient data were divided into quartiles according index: group 1: ≤ 8.62;...

The present study aimed to evaluate the predictive role of inflammatory biomarkers in development contrast-induced acute kidney injury (CI-AKI) coronary syndrome (ACS) patients undergoing percutaneous intervention (PCI). assessed were: platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte (MLR), neutrophil-to-lymphocyte (NLR), derived (dNLR), neutrophil-to-lymphocyte*platelet (NLPR), systemic index (SII), and inflammation response (SIRI). Overall, 950 PCI were enrolled. frequency CI-AKI...

Stress hyperglycemia ratio is a novel indicator of acute coronary synthesis (ACS), which closely related to the severity and complications ACS other cardiovascular diseases. However, its relationship with progression non target lesions remains unclear. The purpose this paper explore between stress lesions. This study retrospectively enrolled patients diagnosed syndrome who underwent stent implantation follow-up evaluations by angiography at Zhongda Hospital January 2019 2024. Patients were...

Background Triglyceride-glucose (TyG) index is a reliable and specific biomarker for insulin resistance associated with renal dysfunction. The present study sought to explore the relationship between TyG incidence of contrast-induced nephropathy (CIN) in non-ST elevation acute coronary syndrome (NSTE-ACS) patients implanted drug-eluting stents (DESs). Methods A total 1108 participants were recruited assigned two groups based on occurrence CIN. was calculated as ln [fasting triglycerides...

Abstract Background Pulmonary arterial hypertension (PAH) is a devastating chronic cardiopulmonary disease without an effective therapeutic approach. The underlying molecular mechanism of PAH remains largely unexplored at single-cell resolution. Methods Single-cell RNA sequencing (scRNA-seq) data from the Gene Expression Omnibus (GEO) database (GSE210248) was included and analyzed comprehensively. Additionally, microarray transcriptome including 15 lung tissue patients 11 normal samples...

We investigated the possibility of urethroplasty with a free graft colonic mucosa for long, complex urethral strictures. report our initial experience such strictures in 16 patients.Between September 2000 and December 2002, patients stricture were treated mucosal urethroplasty. Patients had undergone an average 2.5 previous unsuccessful repairs. Urethral reconstruction was done 10 to 17 cm (median 13) mucosaPatients followed 6 33 months postoperatively. Meatal stenosis that developed 1...

Intimal hyperplasia, the key event of arterial restenosis, is a result cell proliferation and migration. Atorvastatin exerts an inhibitory effect on migration, but mechanism remains largely unknown. p16, as well-known tumor suppressor, was also reported to suppress growth with unclear mechanism. In this study, we demonstrated that atorvastatin represses migration in vascular smooth muscle cells (VSMCs) process mediated by p16. Furthermore, found DNA methylation p16 promoter reduced...

The mitochondrial pyruvate carrier (MPC) complex, located on the inner membrane, transports to matrix for oxidative phosphorylation. Previous studies have shown that MPC complex is a key regulator of glycolysis in tumor cells. present study evaluated role under hypoxic conditions human umbilical vein endothelial cells, which rely energy generation. It was indicated hypoxia led an increase lactate secretion and decrease MPC1 MPC2 levels, were upregulated following re‑oxygenation. In addition,...

Sarco-endoplasmic reticulum Ca2+ ATPase (SERCA) pumps take up from the cytoplasm to maintain balance of intracellular Ca2+. A decline in expression or activity SERCA results persistent store-operated calcium entry (SOCE). In cardiomyocytes as well vascular smooth muscle cells (SMCs), SERCA2 acts an important regulator cycling. The purpose this study is identify and better understand role transglutaminases2 (TG2) a key factor involved serotonination (s-SERCA2) elucidate underlying mechanism...

Abstract Background: Hypoxic pulmonary hypertension (HPH) is a devastating and incurable disease characterized by vascular remodeling, resulting in right heart failure even death. Accumulated evidence has confirmed long coding RNAs (lncRNAs) are involved hypoxia-induced remodeling HPH. The exact mechanism of lncRNA hypoxic remains unclear. Methods: Microarray analysis was applied to investigate the profiles expression artery smooth muscle cells (PASMCs) cultured under hypoxia normoxia...

Background . Renal vasoconstriction, oxidative stress, endothelial dysfunction, and apoptosis are the major causes of contrast-induced nephropathy (CIN). The aim this study was to evaluate protective effects enalapril maleate folic acid tablets on CIN in diabetic rats. Methods Thirty-two Sprague-Dawley rats were divided into four groups: (C), + (CE), (CF), (CEF). CE, CF, CEF treated orally with maleate, acid, or tablets, respectively, for 5 days. induced all groups followed by analyzed...