A5100391438- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Circular RNAs in diseases
- Nerve injury and regeneration
- RNA Research and Splicing
- Energy, Environment, Economic Growth
- Cancer-related gene regulation
- Municipal Solid Waste Management
- Signaling Pathways in Disease
- Spinal Cord Injury Research
- PARP inhibition in cancer therapy
- Sirtuins and Resveratrol in Medicine
- Lung Cancer Research Studies
- Recycled Aggregate Concrete Performance
- Polymer Nanocomposites and Properties
- Wound Healing and Treatments
- Hemispheric Asymmetry in Neuroscience
- MicroRNA in disease regulation
- Autophagy in Disease and Therapy
- Healthcare and Environmental Waste Management
- Silicone and Siloxane Chemistry
- Ovarian cancer diagnosis and treatment
- Electromagnetic Fields and Biological Effects
- Polymer composites and self-healing
- Pulmonary Hypertension Research and Treatments
Tianjin Medical University Cancer Institute and Hospital
2024
National Clinical Research
2024
Beijing University of Chemical Technology
2024
Nantong University
2019-2023
Shandong Provincial Hospital
2022
Shandong First Medical University
2022
Zhongda Hospital Southeast University
2020
Shandong Provincial QianFoShan Hospital
2019
Shandong University
2019
Yangzhou University
2019
Activation of CXCL12/CXCR4 axis has been found to be associated with invasion and metastasis in many cancers. However, the underlying mechanism remains elusive. Increasing data highlight that non-coding RNAs are linked CRC progression. The effects CXCR4 were investigated using villin-CXCR4 transgenic mice model by flow cytometry assay, immunohistochemistry, Western blot. was explored through bioinformatics, luciferase reporter assay RNA immunoprecipitation assay. We high expression...
Elastomers with high strength and toughness are in great demand. Previous research on elastomers focused mainly the design of new chemical structures, but their complicated synthesis process expensive monomers have restricted practical application these materials. Inspired by general filler effects, a strategy is proposed to remarkably enhance mechanical properties thermoplastic polyurethane (TPU) designing arrangement hard/soft segments using traditional compositions. By utilizing...
Osteoclasts (OC) are unique terminally differentiated cells whose primary function is bone resorption. We previously showed that osteoprotegerin (OPG) inhibits OC differentiation in vitro by enhancing autophagy via the adenosine monophosphate-activated protein kinase (AMPK)/mTOR/p70S6K signalling pathway vitro. Here, we aimed to elucidate mechanism of AMPK mediated regulate OPG-mediated inhibition and identify potential therapeutic targets associated with loss.We used activator AICAR...
The intrinsic regeneration ability of neurons is a pivotal factor in the repair peripheral nerve injury. Therefore, identifying key modulators may help improve axon and functional recovery after Unlike for classical transcription factors regeneration-associated genes, function long noncoding RNAs (lncRNAs) regulation neuronal remains mostly unknown. In this study, we used RNA-Seq-based transcriptome profiling to analyze expression patterns lncRNAs mRNAs rat dorsal root ganglion (DRG)...
A key limiting factor of successful axon regeneration is the intrinsic regenerative ability in both peripheral nervous system (PNS) and central (CNS). Previous studies have identified regulators that act on gene expression injured neurons. However, it less known whether RNA modifications play a role this process. Here, we systematically screened functions all common m6A modification-related enzymes report ALKBH5, an evolutionarily conserved demethylase, as regulator axonal rodents. In PNS,...
The effect of lncRNA X inactive-specific transcript (XIST) inducing cardiovascular diseases on deep vein thrombosis (DVT) and its mechanism has not been reported. In this study, we uncovered the mystery that XIST causes DVT with HUVEC dysfunction. expression levels miR-103a-3p were detected by qRT-PCR, HMGB1 was determined qRT-PCR western blot. correlations among XIST, miR-103a-3p, Spearman's rank-order correlation test. siRNA (si-XIST) transfected into HUVECs to knock down intrinsic XIST....
Abstract Background: Hypoxic pulmonary hypertension (HPH) is a devastating and incurable disease characterized by vascular remodeling, resulting in right heart failure even death. Accumulated evidence has confirmed long coding RNAs (lncRNAs) are involved hypoxia-induced remodeling HPH. The exact mechanism of lncRNA hypoxic remains unclear. Methods: Microarray analysis was applied to investigate the profiles expression artery smooth muscle cells (PASMCs) cultured under hypoxia normoxia...
Industrial solid waste (ISW) accounts for the most significant proportion of in China. Improper treatment ISW will cause environmental pollution. As basis decision-making and management resource utilization, accurate prediction industrial generation (ISWG) is crucial. Therefore, combined with China’s national conditions, this paper selects 14 influential factors four aspects: society, economy, environment technology, then proposes a new model called principal component analysis nonlinear...
Abstract Adolescence is a critical developmental stage during which substantial remodeling occurs in brain areas involved emotional and learning processes. Although robust literature on the biological effects of extremely low frequency magnetic fields (ELF‐MFs) has been documented, data ELF‐MF exposure this period cognitive functions remain scarce. In study, early adolescent male mice were exposed from postnatal day (P) 23–35 to 50 Hz MF at 2 mT for 60 min/day. On P36–45, potential spatial...
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are a continuum of life-threatening changes. Pulmonary vascular is one the most important initial causes ALI ARDS. However, functions long noncoding RNAs (lncRNAs) in pulmonary endothelial remain largely unknown. The aim present study was to determine lncRNA expression profile human microvascular cells (HPMECs) exposed lipopolysaccharide (LPS) explore potential differentially expressed lncRNAs.Microarray analysis used...
Peripheral nerves can self-regenerate after traumatic injury, although their self-regeneration ability is limited severe nerve injury. After peripheral the distal stumps undergo Wallerian degeneration while proximal a regeneration process.Here, to decipher genetic changes and involved biological processes in microarray data (GSE30165) were analyzed. Differentially expressed genes at 0.5 h, 1 3 6 9 d, 4 7 14 d rat sciatic transection subjected Ingenuity pathway analysis (IPA) bioinformatic...
<title>Abstract</title> Identifying novel and effective treatments is urgent to reduce the recurrence rates drug resistance of patients with ovarian cancer, given deficiencies traditional treatments. In this study, we evaluated synergistic effects combining niraparib (NIR) anlotinib (ANL) on their anti-proliferative, anti-migratory, anti-stem cell, pro-apoptotic abilities cancer cells <italic>in vitro</italic> vivo</italic>. <italic>In vitro</italic>, NIR combined ANL inhibited clone...
Abstract A key limiting factor of successful axon regeneration is the intrinsic regenerative ability in both peripheral (PNS) and central nervous system (CNS). Previous studies have identified regulators that act on gene expression injured neurons. However, it less known if RNA modifications play a role this process. Here, we systematically screened functions all common m6A modification-related enzymes report ALKBH5, an evolutionarily conserved demethylase, as regulator axonal regeneration....