A5101694858- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- T-cell and B-cell Immunology
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Immunotherapy and Biomarkers
- Hepatitis C virus research
- Circular RNAs in diseases
- Monoclonal and Polyclonal Antibodies Research
- Complement system in diseases
- Immune Cell Function and Interaction
- Vector-borne infectious diseases
- Vector-Borne Animal Diseases
- Hematopoietic Stem Cell Transplantation
- Systemic Lupus Erythematosus Research
- Immunotherapy and Immune Responses
- Atherosclerosis and Cardiovascular Diseases
- Galectins and Cancer Biology
- MicroRNA in disease regulation
- Renal Diseases and Glomerulopathies
- Infectious Encephalopathies and Encephalitis
- Bacterial biofilms and quorum sensing
- Lymphoma Diagnosis and Treatment
- Wave and Wind Energy Systems
- Magnetic Properties and Synthesis of Ferrites
Fourth Affiliated Hospital of Harbin Medical University
2025
Harbin Medical University
2021-2025
Zunyi Medical University
2024-2025
Peking Union Medical College Hospital
2022-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2022-2024
Sun Yat-sen University Cancer Center
2023
Sun Yat-sen University
2023
Tianjin Medical University
2016-2022
Third Affiliated Hospital of Harbin Medical University
2021-2022
Shanghai Jiao Tong University
2017-2021
Activation of CXCL12/CXCR4 axis has been found to be associated with invasion and metastasis in many cancers. However, the underlying mechanism remains elusive. Increasing data highlight that non-coding RNAs are linked CRC progression. The effects CXCR4 were investigated using villin-CXCR4 transgenic mice model by flow cytometry assay, immunohistochemistry, Western blot. was explored through bioinformatics, luciferase reporter assay RNA immunoprecipitation assay. We high expression...
Abstract Gallbladder cancer (GBC) is the most common type of biliary tract worldwide. Long noncoding RNAs (lncRNAs) play essential roles in physiological and pathological development. LncRNA MEG3 , a tumor suppressor, has been reported to important some cancers, but role GBC remains largely unknown. The purpose present study was explore proliferation invasion potential molecular mechanism GBC. We found that downregulated tissues cells, low expression correlated with poor prognostic outcomes...
Abstract Gallbladder cancer (GBC) accounts for 85–90% malignancies of the biliary tree worldwide. Considerable evidence has demonstrated that dysregulation lncRNAs is involved in progression cancer. LncRNA PVT1 been reported to play important roles various cancers, but its role gallbladder remains unknown. In present study, we found was upregulated GBC tissues and cells, upregulation related with poor prognosis patients. promoted cells proliferation vitro vivo. Mechanistically, recruited...
T cell-mediated immunity plays a significant role in the development of atherosclerosis (AS). There is increasing evidence that CD8+ cells are also involved AS but their exact roles remain unclear. The inhibitory receptors programmed cell death-1 (PD-1) and immunoglobulin mucin domain 3 (Tim-3) well known molecules play crucial regulating activation or tolerance. Here, we demonstrate co-expression PD-1 Tim-3 on up-regulated patients. PD-1+ Tim-3+ enriched for within central (TCM) subset,...
MicroRNAs (miRNAs) exhibit a crucial role in the regulation of angiogenesis and tumor progression, which miR-199a-5p (miR-199a) has been reported to function as suppressor multiple malignancies. However, precise mechanisms underlying miR-199a hemangiomas (HAs) remain elusive. In this study, we found that had low expression level, while proliferating cell nuclear antigen (PCNA) high level proliferating-phase HAs compared with involuting-phase normal tissues. Spearman correlation analysis...
Novel cyclodextrin derivative, glutamine-β-cyclodextrin, is developed as DOX carrier to minimize its side effects <italic>via</italic> TNBC tumors addiction glutamine.
The role of lncRNAs in gallbladder cancer (GBC) remains poorly understood. In this study, we explored the function functional intergenic repeating RNA element (FIRRE) GBC. Whole transcriptome resequencing was performed three pairs GBC tissues and adjacent non-tumor tissues. lncRNA FIRRE expression verified by real-time PCR. evaluated experiments vitro vivo. mechanism investigated via fluorescent situ hybridization, pull-down, dual luciferase reporter assays, immunoprecipitation. level...
The present study aimed to analyze the effects of acetylation-related lncRNAs in non-small-cell lung cancer (NSCLC). A total 399 differentially expressed (DElncRNAs) have been identified between 497 NSCLC tissues and 54 normal TCGA database, 105 which were correlated with acetylation regulators. By using univariate cox regression analysis combining it clinical prognosis information, 12 prognostic-related selected for subsequent analysis. patients divided into two subgroups (cluster 1 cluster...
SUMMARY Anaplasmosis is caused by a group of obligate intracellular bacteria in the genus Anaplasma , which are transmitted ticks and infect humans, domestic animals wildlife. This study was conducted to determine prevalence molecular characterization spp. semi-wild white yaks sampled Tianzhu Tibetan Autonomous County, northwest China. Out 332 samples tested, 35 (10·9%) were positive for The rates 6·2% (20/322) 5·3% (17/322) bovis phagocytophilum yaks, respectively. None sample marginale ....
Dysregulation of long non‑coding RNA (IncRNA) antisense in the INK4 locus (ANRIL) is associated with risk myocardial infarction (MI). Therefore, present study aimed to determine mechanisms underlying this association, which currently poorly understood, best our knowledge. The current used an vitro ischemia and reperfusion (MI/R) model, H9c2 cardiomyocytes were exposed hypoxia/reoxygenation (H/R), demonstrated that ANRIL expression was downregulated positively regulated sirtuin 1 (SIRT1)...
Endothelial injury and dysfunction followed by endothelial activation inflammatory cell recruitment are factors contributing to the initiation progression of atherosclerosis. Oxidized low-density lipoprotein (ox-LDL) promotes inflammation during atherogenesis lipid deposition in arterial wall. We observed that stimulation human umbilical vein cells (HUVECs) with ox-LDL activated pro-inflammatory cytokine production apoptosis, inhibited migration, upregulated T-cell immunoglobulin mucin...
In recent years, carbapenem-resistant Klebsiella pneumoniae (CRKP) has emerged rapidly in China with the abuse and overuse of antibiotics, infections caused by CRKP pose a serious threat to global public health safety. The present study aimed explore epidemiological characteristics isolates Northern elucidate their drug resistance mechanisms.45 strains were consecutively collected at teaching hospital from March 1st, 2018 June 30th, 2018. Antimicrobial susceptibility was determined VITEK2...