A5101577264- interferon and immune responses
- Viral Infections and Vectors
- Viral Infections and Immunology Research
- Cytomegalovirus and herpesvirus research
- Herpesvirus Infections and Treatments
- Viral gastroenteritis research and epidemiology
- Vector-borne infectious diseases
- Mosquito-borne diseases and control
- Vector-Borne Animal Diseases
- RNA regulation and disease
- Inflammasome and immune disorders
- Immune Response and Inflammation
- Virus-based gene therapy research
- Animal Virus Infections Studies
- SARS-CoV-2 and COVID-19 Research
- Influenza Virus Research Studies
- Autophagy in Disease and Therapy
- Uterine Myomas and Treatments
- Gynecological conditions and treatments
- Endometriosis Research and Treatment
- CO2 Reduction Techniques and Catalysts
- RNA and protein synthesis mechanisms
- Ectopic Pregnancy Diagnosis and Management
- Advanced Nanomaterials in Catalysis
- Spondyloarthritis Studies and Treatments
Minzu University of China
2022-2025
State Ethnic Affairs Commission
2020-2025
Sichuan University
2021-2024
West China Hospital of Sichuan University
2021-2024
Guangzhou Medical University
2020-2024
Gansu Agricultural University
2019-2024
State Key Laboratory of Oral Diseases
2024
Xi'an Peihua University
2023
Robert Bosch (Germany)
2023
Stomatology Hospital
2022
Abstract Natural immunity is the first defense line of host immune system, which plays a significant role in combating foreign pathogenic microorganisms. The IFN-β (interferon-beta) signaling pathway, being typical example innate immunity, vital function. This study aimed to elucidate function pseudorabies virus (PRV) UL38 protein (unique long region 38) suppressing activation pathway. findings from our indicate that PRV effectively hampers by poly (dA: dT)...
Objective: The purpose of this study was to explore the therapeutic characteristics mesenchymal stem cells generated from human umbilical cord (hUC-MSCs) when utilized in conjunction with auto-crosslinked hyaluronic acid gel (HA-gel) for management intrauterine adhesion (IUA). goal see how novel therapy could enhance healing and improve outcomes IUA patients. Methods: In study, models (IUA) were established Sprague-Dawley (SD) rats, which then organized divided into hUC-MSCs groups. groups...
Herpesviruses antagonize host antiviral responses through a myriad of molecular strategies culminating in the death cells. Pseudorabies virus (PRV) is significant veterinary pathogen pigs, causing neurological sequalae that ultimately lead to animal's demise. PRV known trigger apoptotic cell during late stages infection. The virion shutdown protein (VHS) encoded by UL41 plays crucial role infection process. In this study, we demonstrate inhibits PRV-induced activation inflammatory cytokine...
Anaplasma phagocytophilum is a causative agent of granulocytic anaplasmosis in mammals, which has broad geographical distribution and high degree clinical diversity. Currently, numerous PCR assays have been developed used for the detection A. various specimens. However, their performance varies. The aim this study was to evaluate five nested by 363 ruminant tick samples, select most appropriate methods sensitive environmental or samples. Positive results were obtained 75 (20.7 %), 42 (11.6...
Encephalomyocarditis virus is an important pathogen that can cause encephalitis, myocarditis, neurological diseases, and reproductive disorders. It also causes huge economic losses for the swine industry worldwide.
Pseudorabies virus is a typical swine alphaherpesvirus, which can cause obvious neurological disorders and reproductive failure in pigs. It capable of evading host antiviral immune response. However, the mechanism by many PRV proteins assist to evade innate immunity not fully understood. This study identified US3 protein as crucial antagonistic viral factor that represses interferon beta (IFN-β) expression. A in-depth showed restricted type I IFN production targeting regulatory 3 (IRF3), key...
Interferon (IFN) helps cells fight viral infections by further inducing the expression of many downstream IFN-stimulated genes (ISGs). Human interferon-inducible transmembrane proteins (IFITM) are one these ISGs. The antiviral function human IFITM1, IFITM2, and IFITM3 well known. In this study, we report that IFITM can significantly inhibit EMCV infectivity in HEK293 cells. Overexpression could promote IFN-β production. Meanwhile, IFITMs facilitated type I IFN signaling pathway adaptor MDA5...
Pseudorabies (PR) is a domestic and wild animal infectious disease caused by the pseudorabies virus (PRV) one of major diseases that endanger global swine industry. Studies have reported PRV may achieve cross-species transmission from pigs to humans in recent years. Therefore, in-depth exploration relationship between host proteins great significance for elucidating pathogenic mechanism anti-PRV infection. Here, we report heat shock protein 27 (HSP27) ubiquitinates degrades cyclic GMP-AMP...
SUMMARY Anaplasmosis is caused by a group of obligate intracellular bacteria in the genus Anaplasma , which are transmitted ticks and infect humans, domestic animals wildlife. This study was conducted to determine prevalence molecular characterization spp. semi-wild white yaks sampled Tianzhu Tibetan Autonomous County, northwest China. Out 332 samples tested, 35 (10·9%) were positive for The rates 6·2% (20/322) 5·3% (17/322) bovis phagocytophilum yaks, respectively. None sample marginale ....
Mammalian orthoreovirus (MRV) outer capsid protein σ3 is a multifunctional containing double-stranded RNA-binding domain, which facilitates viral entry and assembly. We reasoned that has an innate immune evasion function. Here, we show localizes in the mitochondria interacts with mitochondrial antiviral signaling (MAVS) to activate intrinsic mitochondria-mediated apoptotic pathway. Consequently, promotes degradation of MAVS through caspase-9/caspase-3 Moreover, can also inhibit expression...
Background: Understanding the mechanisms through which interferon (IFN) signaling is negatively regulated crucial for preserving equilibrium of innate immune reactions, as system functions, such original barrier, combat threats to host. Although function encephalomyocarditis virus (EMCV) viral proteins in antagonizing immunity has been related earlier studies, precise mechanism underlying role protein 3 (VP3) type I IFN yet be fully illuminated. Methods: VP3 expression and many other adaptor...
Heat shock proteins (HSPs) are a protein family that respond to physiological stress, such as heat, starvation, and infection. As cellular chaperones, they play an important role in folding, assembly, degradation. Though it is well known HSP27 involved range of viral infections, its during encephalomyocarditis virus (EMCV) infection not known. Here, we report EMCV degrades 2Cpro 3Apro primarily responsible for Consequently, loss augmented proliferation, effect could be reversed upon...
Nuclear factor κB (NF-κB) is involved in a wide range of innate immune activities host cells and serves as an important component host’s immunity system. To survive infected cells, viruses have evolved intricate strategies to evade the response. Pseudorabies virus (PRV) member alpha herpesvirus family capable causing reproductive neurological dysfunction pigs. PRV has large DNA genome therefore ability encode numerous proteins that modulate responses. In present study, we demonstrated...
Objective Existing studies have conflicting results about the predictors of forgotten joints in patients with total knee arthroplasty (TKA), and relationship between psychosocial factors knees is unknown. The purpose this study was to confirm for joint TKA patients. Methods This an observational, prospective longitudinal study. A 205 who underwent a 6‐month follow‐up were included August 2020 September 2021. Demographic characteristics, clinical variables collected before surgery (T0). score...