Abstract Background Insulin resistance (IR) is considered a pivotal risk factor for cardiometabolic diseases, and the triglyceride–glucose index (TyG index) has emerged as reliable surrogate marker of IR. Although several recent studies have shown association TyG with vascular disease, no further investigated role in acute ST-elevation myocardial infarction (STEMI). The objective present study was to evaluate potential predictor prognosis STEMI patients after percutaneous coronary...

Background Endothelial dysfunction, a hallmark of diabetes, is critical and initiating contributor to the pathogenesis diabetic cardiovascular complications. However, underlying mechanisms are still not fully understood. Ferroptosis newly defined regulated cell death driven by cellular metabolism iron-dependent lipid peroxidation. Although involvement ferroptosis in disease has been shown cancers degenerative diseases, participation endothelial dysfunction remains unclear. Aim To examine...

Background and Objectives Triglyceride-glucose (TyG) is an emerging vital indicator of insulin resistance associated with increased risk T2DM cardiovascular events. We aimed to explore the TyG index contrast-induced acute kidney injury (CI-AKI) in patients type 2 diabetes who underwent coronary angiology. Methods This study enrolled 928 suspected artery disease angiology or percutaneous intervention Zhongda hospital. Patient data were divided into quartiles according index: group 1: ≤ 8.62;...

Background: To explore the association between gamma-glutamyltransferase (GGT) and in-hospital heart failure (HF) in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI). Methods: A total of 412 diagnosed STEMI treated PCI were included our study. Univariate multivariate logistic regression models used to evaluate GGT risk HF patients. The receiver operating characteristic (ROC) curve was assess accuracy predicting HF....

Intimal hyperplasia, the key event of arterial restenosis, is a result cell proliferation and migration. Atorvastatin exerts an inhibitory effect on migration, but mechanism remains largely unknown. p16, as well-known tumor suppressor, was also reported to suppress growth with unclear mechanism. In this study, we demonstrated that atorvastatin represses migration in vascular smooth muscle cells (VSMCs) process mediated by p16. Furthermore, found DNA methylation p16 promoter reduced...

Sarco-endoplasmic reticulum Ca2+ ATPase (SERCA) pumps take up from the cytoplasm to maintain balance of intracellular Ca2+. A decline in expression or activity SERCA results persistent store-operated calcium entry (SOCE). In cardiomyocytes as well vascular smooth muscle cells (SMCs), SERCA2 acts an important regulator cycling. The purpose this study is identify and better understand role transglutaminases2 (TG2) a key factor involved serotonination (s-SERCA2) elucidate underlying mechanism...

Abstract Background: Hypoxic pulmonary hypertension (HPH) is a devastating and incurable disease characterized by vascular remodeling, resulting in right heart failure even death. Accumulated evidence has confirmed long coding RNAs (lncRNAs) are involved hypoxia-induced remodeling HPH. The exact mechanism of lncRNA hypoxic remains unclear. Methods: Microarray analysis was applied to investigate the profiles expression artery smooth muscle cells (PASMCs) cultured under hypoxia normoxia...

Background . Renal vasoconstriction, oxidative stress, endothelial dysfunction, and apoptosis are the major causes of contrast-induced nephropathy (CIN). The aim this study was to evaluate protective effects enalapril maleate folic acid tablets on CIN in diabetic rats. Methods Thirty-two Sprague-Dawley rats were divided into four groups: (C), + (CE), (CF), (CEF). CE, CF, CEF treated orally with maleate, acid, or tablets, respectively, for 5 days. induced all groups followed by analyzed...

Abstract Background We aim to find out the relationship between random blood glucose (RBG), fasting (FBG) and in-hospital adverse events in ST-segment elevation acute myocardial infarction (STEMI) patients. evaluate compare predictive value of RBG FBG on events, give an appropriate cut-off FBG. Method A retrospective study enrolled 958 consecutive AMI patients undergoing emergency coronary angiography at Zhongda Hospital were from January 1, 2016, December 31, 2018 was performed. FBG,...

// Boqian Zhu 1, * , Xinmin Si 2, Yaoyao Gong Gaoliang Yan 1 Dong Wang Yong Qiao Bo Liu Jiantong Hou and Chengchun Tang Department of Cardiology, Zhongda Hospital, Southeast University, Nanjing, China 2 Gastroenterology, The First Affiliated Hospital Nanjing Medical These authors contributed equally to this work Correspondence to: Tang, email: tangchengchun@medmail.com.cn Keywords: premature coronary artery disease, G894T, Glu298Asp, polymorphism, endothelial nitric oxide synthase Received:...

Anaemia and high haemoglobin levels are common in ST elevation myocardial infarction (STEMI) patients, but the effect of level on prognosis STEMI patients remains dispute. This study aimed to evaluate prognostic value combined with CAMI-STEMI score after percutaneous coronary intervention (PCI). We included 360 who underwent PCI. The were divided into 3 groups according first Clinical characteristics incidence major adverse cardiovascular cerebral events (MACCE) during follow-up period...

Background and Aims. CIN is a major serious complication following PCI in patients with ACS. It unclear whether higher serum ferritin level associated an increased risk of high-risk patients. Thus, we conducted this study to assess the predictive value SF for after PCI. Methods. We prospectively examined levels 548 ACS before undergoing Multivariate logistic regression analysis was used analyze independent factors CIN. The ROC performed evaluate Results. occurred 96 Baseline who developed...

Contrast-induced acute kidney injury (CI-AKI) is a serious complication of percutaneous coronary intervention (PCI) in patients with ST-segment elevation myocardial infarction (STEMI). Early identification high-risk has an essential role preventing CI-AKI. This study was designed to evaluate the predictive value d-dimer, marker thrombosis and hypercoagulable state, for CI-AKI prognosis STEMI. We included 400 STEMI who underwent PCI. The were subdivided into 4 groups according d-dimer level...

Platelet-derived growth factor-BB (PDGF-BB) can induce the proliferation, migration, and phenotypic modulation of vascular smooth muscle cells (VSMCs). We used patch clamp methods to study effects PDGF-BB on inward rectifier K + channel 2.1 (Kir2.1) channels in rat thoracic aorta VSMCs (RASMCs). (25 ng/mL) increased Kir2.x currents (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mo>−</mml:mo><mml:mn>11.81</mml:mn><mml:mo>±</mml:mo><mml:mn>2.47</mml:mn></mml:math>...

To explore the impact of plasma homocysteinemia(Hcy) on contrast-induced nephropathy (CIN) after percutaneous coronary intervention (PCI) in acute syndrome (ACS) patients.Consecutive 684 ACS patients undergoing first PCI our department between January 2013 and December 2014 were prospectively enrolled.Patients divided into 2 groups according to pre-procedural Hcy level: high-Hcy group (Hcy≥10 μmol/L, n=404) control (Hcy<10 n=280). The CIN was defined as serum creatinine ≥ 44.2 μmol/L or 25%...

Contrast-induced nephropathy (CIN) is a relatively infrequent complication after percutaneous coronary intervention (PCI) in patients with ST-elevation myocardial infarction (STEMI). However, little known about the association between cytochrome c (cyt c) and increased risk of CIN. We conducted this study to explore impact serum cyt on occurrence CIN.We prospectively examined levels before undergoing PCI 240 STEMI. The logistic regression was performed identify independent factors for...