A5101667631- Acute Myocardial Infarction Research
- Traditional Chinese Medicine Studies
- Cardiovascular Function and Risk Factors
- Cardiac Arrhythmias and Treatments
- Cardiac Imaging and Diagnostics
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiovascular Disease and Adiposity
- Cardiac Structural Anomalies and Repair
- Heart Failure Treatment and Management
- Coronary Interventions and Diagnostics
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Cardiovascular Issues in Pregnancy
- Bone health and osteoporosis research
- Peptidase Inhibition and Analysis
- Cardiac Ischemia and Reperfusion
- Cardiac Health and Mental Health
- Thyroid Disorders and Treatments
- Trauma Management and Diagnosis
- Cardiomyopathy and Myosin Studies
- Liver Disease Diagnosis and Treatment
- Cardiac and Coronary Surgery Techniques
- Cardiac electrophysiology and arrhythmias
- Electrolyte and hormonal disorders
- Acute Kidney Injury Research
- Artificial Intelligence in Healthcare
Zhejiang Chinese Medical University
2024
Zhongda Hospital Southeast University
2019-2024
CM Hospital
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2007-2021
Academy of Medical Sciences
2021
Tangshan Gongren Hospital
2021
University of California, San Francisco
2019
Cardiovascular Research Center
2019
University Medical Center Hamburg-Eppendorf
2019
University of Tennessee Health Science Center
2012-2018
Abstract Background Insulin resistance (IR) is considered a pivotal risk factor for cardiometabolic diseases, and the triglyceride–glucose index (TyG index) has emerged as reliable surrogate marker of IR. Although several recent studies have shown association TyG with vascular disease, no further investigated role in acute ST-elevation myocardial infarction (STEMI). The objective present study was to evaluate potential predictor prognosis STEMI patients after percutaneous coronary...
Background— A20 was originally characterized as a tumor necrosis factor–inducible gene in human umbilical vein endothelial cells. As an inhibitor of nuclear factor-κB signaling, protects against apoptosis, inflammation, and cardiac hypertrophy. In the present study, we tested hypothesis that cardiac-specific overexpression could protect heart from myocardial infarction. Methods Results— We investigated role constitutive expression acute infarction using transgenic model. Transgenic mice...
Heart failure, caused by dilated cardiomyopathy and other cardiac disorders such as hypertension, is a major public health problem with high morbidity mortality. Corin, enzyme that cleaves natriuretic peptides, promising biomarker of heart but its functional role in these processes not understood. We evaluated the potential effects corin mice well-characterized model cardiomyopathy. Mice developed reduced contractile function, fibrosis, accelerated mortality setting low expression. In...
Dilated cardiomyopathy is a major cause of heart failure (HF) that affects millions. Corin cleaves and biologically activates pro-atrial natriuretic peptide (pro-ANP) pro-B-type (pro-BNP). High corin levels reduce the development systolic dysfunction HF in experimental dilated cardiomyopathy. Yet, patients with significant unexpectedly show low high plasma ANP/BNP levels. Therefore, we examined relationship between cardiac expression, levels, stages HF. We used well-established, model to...
Objective Elevated levels of N-terminal pro-brain natriuretic peptide (NT-proBNP) are associated with heart failure-related death in hypertrophic cardiomyopathy (HCM), but the relationship between NT-proBNP level and sudden cardiac (SCD) HCM remains undefined. Methods The study prospectively enrolled 977 unrelated patients available results who were followed for 3.0±2.1 years. Harrell’s C-statistic under receiver operating characteristic curve was calculated to evaluate discrimination...
The prevalence of thyroid dysfunction diseases (TDFDs) and osteoporosis (OP) is high. Previous studies have indicated a potential association between TDFDs OP, yet the causal direction remains unclear. This study aimed to investigate relationship risk developing OP related fractures. We obtained pooled data from genome-wide (GWASs) conducted on in European populations identified single-nucleotide polymorphisms (SNPs) with significance levels associated exposure as instrumental variables....
Following acute myocardial infarction, clinical studies show alterations in the blood levels of corin, a cardiac-selective activator natriuretic peptides pro-atrial peptide (pro-ANP) and pro-B-type (pro-BNP). However, temporal changes circulating cardiac corin their relationships to severity infarction have not been studied. The main objective this study was examine relationship between association with systolic function infarct size during early phase (<72 h) translationally relevant...
The use of animal models is essential for developing new therapeutic strategies acute coronary syndrome and its complications. In this article, we demonstrate a murine cryoinjury infarct model that generates precise sizes with high reproducibility replicability. brief, after intubation sternotomy the animal, heart lifted from thorax. probe handheld liquid nitrogen delivery system applied onto myocardial wall to induce cryoinjury. Impaired ventricular function electrical conduction can be...
Contrast-induced acute kidney injury (CI-AKI) is a serious complication of percutaneous coronary intervention (PCI) in patients with ST-segment elevation myocardial infarction (STEMI). Early identification high-risk has an essential role preventing CI-AKI. This study was designed to evaluate the predictive value d-dimer, marker thrombosis and hypercoagulable state, for CI-AKI prognosis STEMI. We included 400 STEMI who underwent PCI. The were subdivided into 4 groups according d-dimer level...
Abstract Background Thyroid dysfunction diseases (TDFDs) and osteoporosis (OP) have a high prevalence in the population. Previous studies indicated potential association between TDFDs OP, yet causal direction remains unclear. This study aims to investigate relationship risk of developing OP related fracture. Methods We obtained pooled data from genome-wide (GWAS) conducted on European populations, identified single nucleotide polymorphisms (SNPs) with significance levels associated exposure...
<title>Abstract</title> Background Insulin resistance (IR) is a pivotal pathogenesis characteristic of type 2 diabetes mellitus (T2DM). The current study aimed to explore the association between three surrogate biomarkers for IR, including triglyceride/high-density lipoprotein cholesterol ratio (TG/HDL-c), triglyceride-glucose (TyG), and triglyceride glucose-body mass index (TyG-BMI), T2DM incidence compare predictive value these parameters in T2DM. Methods A total 116855 Chinese adults aged...
Left-ventricular diverticulum (LD) associated with patent ductus arteriosus (PDA) is extremely rare. We have not found any previous reports of the coexistence these two malformations. Such an association presenting chest pain mimicking infarct aneurysm angina or a takotsubo cardiomyopathy difficult to differentiate clinically. Here, we discuss several diseases characterized by left-ventricular apical protrusion familiarize clinicians differential diagnosis diseases. A 58-year-old woman was...
Objective To explore the relationship between syncope and risk of death in patients with cardiovascular emergencies including acute myocardial infarction(AMI), arrhythmia, heart failure(AHF), pulmonary thromboembolism(PTE) aortic dissection(AD) rupture. Methods Data from 2 789 emergency admitted June 2010 to 2016 Emergency Department, Air Force General Hospital, PLA was retrospectively analyzed. Difference gender, age motality were compared those without syncope. Among five kinds...
Objective To study the effectiveness and safety of side-branch (SB) balloon pre-imbedding technique on coronary bifurcation lesions (CBLs) in elderly patients. Methods A retrospective analysis was conducted 111 patients with CBLs our hospital from January 2011 to 2013, whom 59 received SB 52 wire protection. The immediate blood flow after treatment, performance stent, major adverse cardiovascular events (MACE) during hospitalization, 6 12 months angiography treatment were compared...
Objective To investigate the effect of fluvastatin combined with nitroglycerin on acute heart failure in elderly patients hypertension and diabetes. Methods From May 2013 to September 2015, 89 hypertensive diabetes were selected, randomly divided into control group (n=44) observation (n=45). Eighty-nine given conventional treatment. On basis treatment, injection, efficacy two groups was compared. Results After SBP, DBP, FPG HR respectively (112.4±4.6)mmHg(1mm Hg=0.133 kPa),...
OBJECTIVE To investigate the change of cardiac reserve during abnormal pregnancy and explore its evaluation methods. METHODS Totally 96 women with pregnancies (AP group), 356 normal (NP 100 childbearing age (CBA group) were monitored by exercise contractility monitor (ECCM). Phonocardiogram participants at resting status was recorded ECCM. The amplitude first heart sound (S1), second (S2), cycle, diastolic duration (D), systolic (S) detected then S1/S2 ratio,the D/S ratio, rate (HR)...
Objective To analysis the effect of immunomodulatory in treatment chronic congestive heart failure among old people.Methods 100 elderly patients with were randomly divided into objective group (50 cases) and control cases).Control used conventional plan,objective plan on basis group.The differences cardiac function indexes levels inflammatory cytokines between two groups compared.Results The LVEF IL-10 higher than those (P ＜ 0.05).The LVEDD,LVESD,hs-CRP,BNP,TNF-α IL-1 β lower...