Lingyun Jia

ORCID: 0000-0002-9699-3689
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About
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Research Areas
  • Monoclonal and Polyclonal Antibodies Research
  • Protein purification and stability
  • Microbial bioremediation and biosurfactants
  • Glycosylation and Glycoproteins Research
  • Toxic Organic Pollutants Impact
  • Diamond and Carbon-based Materials Research
  • Polymer Surface Interaction Studies
  • Natural product bioactivities and synthesis
  • Microfluidic and Capillary Electrophoresis Applications
  • Microfluidic and Bio-sensing Technologies
  • Advanced Biosensing Techniques and Applications
  • Neonatal Health and Biochemistry
  • Advanced Cellulose Research Studies
  • Alzheimer's disease research and treatments
  • Electrospun Nanofibers in Biomedical Applications
  • Metal and Thin Film Mechanics
  • Advanced biosensing and bioanalysis techniques
  • Biochemical and Structural Characterization
  • Chromatography in Natural Products
  • Microplastics and Plastic Pollution
  • Pharmacological Effects of Natural Compounds
  • Click Chemistry and Applications
  • Platelet Disorders and Treatments
  • T-cell and B-cell Immunology
  • Cancer Cells and Metastasis

Dalian University of Technology
2016-2025

Dalian University
2016-2025

Tianjin University of Science and Technology
2021-2024

Shenyang Pharmaceutical University
2011-2024

Nagoya University
2014-2019

Northwest Normal University
2019

First People’s Hospital of Jingmen
2015

Beijing Jiaotong University
2011

Bioscience (China)
2006

Dalian Institute of Chemical Physics
1998-2000

As a pathogenic toxin, bilirubin is generally removed from blood by hemoperfusion for the remission of liver disease or to gain time patients waiting transplantation. However, development adsorbents with excellent mechanical properties, adsorption performance and hemocompatibility still considerable challenge. In this work, heparin-modified chitosan/graphene oxide hybrid hydrogel (hep-CS/GH) has been developed using lyophilization-neutralization-modification strategy. The as-prepared...

10.1039/c4tb01673d article EN Journal of Materials Chemistry B 2015-01-01

Unwanted adhesion of microalgae on submerged surfaces is a ubiquitous problem across many maritime operations. We explored the strategy developing silver nanoparticle (AgNP) coating for antifouling applications in marine and freshwater environments. In situ growth AgNPs was achieved by polydopamine (PDA)-based method. A range most used industrial materials, including glass, polystyrene, stainless steel, paint surface, even cobblestone, were employed, which AgNP coatings built characterized....

10.1021/am500292y article EN ACS Applied Materials & Interfaces 2014-03-07

10.1016/j.colsurfa.2015.07.061 article EN Colloids and Surfaces A Physicochemical and Engineering Aspects 2015-08-03

HP-β-CD are not only nontoxic to cells, but also greatly inhibits Aβ fibrillization and reduces Aβ-induced toxicity<italic>via</italic>its inner cavity.

10.1039/c6cp03582e article EN Physical Chemistry Chemical Physics 2016-01-01

Nasopharyngeal carcinoma (NPC) is notably prevalent in East and Southeast Asia, where despite advancements radiotherapy leading to high control rates, challenges like radioresistance collateral tissue damage remain significant. While Schisandrin B (SchB) has been demonstrated antitumor effects various tumors, its efficacy NPC remains unexplored. In this study, we explored the potential of Sch on NPC, particularly cell proliferation radiosensitivity. Our research demonstrates that effectively...

10.1038/s41598-025-92992-9 article EN cc-by-nc-nd Scientific Reports 2025-03-11

Tannic acid (TA), a high-molecular-weight polyphenol, is used as hemostasis spray and unguent for trauma wound remedy in traditional medical treatment. However, the use of tannic on large-area would lead to absorption poisoning. In this work, TA coating was assembled quartz/silicon slide, or gauze, via chelation interaction between Fe3+ ions further dressing. Protein adsorption investigated by fluorescence signal, ellipsometry analysis sodium dodecyl sulfate-polyacrylamide gel...

10.3390/ma12111803 article EN Materials 2019-06-03

Surface patterning provides a powerful tool to the diagnosis of platelet adhesion. However, current methodologies constructing platelet-patterned surfaces require laborious and complicated steps. Herein, novel simple platelet-repellent surface was reported by metal (Fe3+ ions)-polyphenol (tannic acid, TA) coordination interaction. The effect significantly better than that poly(ethylene glycol) (PEG) in long-term. Moreover, behavior could extend other polyphenols-functionalized surfaces. On...

10.1021/acsami.6b08930 article EN ACS Applied Materials & Interfaces 2016-09-22

Abstract As a non‐invasive treatment modality, photodynamic therapy has been potential therapeutic method for metastatic and non‐metastatic tumors. In order to further improve the tumor selectivity, phtotoimmunotherapy (PIT) developed recently, which includes antibodies as active targeting ligands. However, traditional monoclonal antibody‐based PIT suffers from long half‐lives extended phototoxic side‐effects in vivo. Herein, type I mechanism‐based photoimmunoconjugate (PIC) is by...

10.1002/adfm.202103629 article EN Advanced Functional Materials 2021-06-25

10.1016/j.ijbiomac.2021.11.164 article EN publisher-specific-oa International Journal of Biological Macromolecules 2021-12-01

A metal–organic cerium tetrahedron having size constraints and cooperated interactions within its cavity was used to selectively recognize tryptophan over other natural amino acids Trp-containing peptides. It applied in quantificational detection of free serum.

10.1039/c2cc36932j article EN Chemical Communications 2012-01-01

The capture of circulating tumor cells (CTCs) mainly depends on the biological affinity and differences in physical properties between peripheral blood mononuclear (PBMCs), but effective CTCs using only a chemical method is still rare. Inspired by excellent anti-inflammatory effects polyphenols, we used polyphenol tannic acid-functionalized (TA-functionalized) film to develop simple yet strategy for label-free CTCs. could be easily prepared within minutes metal–polyphenol coordination...

10.1021/acs.chemmater.8b01646 article EN Chemistry of Materials 2018-06-06

10.1016/j.colsurfa.2012.04.032 article EN Colloids and Surfaces A Physicochemical and Engineering Aspects 2012-05-07

Release of heparin from the surface biomaterials is a feasible and efficient manner for preventing blood coagulation because high bioactivity free low application dosage compared to intravenous injection heparin. Here we report novel method featuring blend heparin-loaded SBA-15, catechol-modified chitosan (CCS), as heparin-releasing film. The release was based on its leakage amino-functionalized mesoporous silica SBA-15 (SBA-15-NH2), which controlled by amino density SBA-15-NH2....

10.1021/am403882x article EN ACS Applied Materials & Interfaces 2013-11-14
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