A5001085357- Circular RNAs in diseases
- MicroRNA in disease regulation
- Liver Disease and Transplantation
- Pulmonary Hypertension Research and Treatments
- Cancer-related molecular mechanisms research
- Liver Disease Diagnosis and Treatment
Zhongda Hospital Southeast University
2023
Nanjing Medical University
2022
Jiangsu Province Hospital
2022
Abstract Background Pulmonary arterial hypertension (PAH) is a devastating chronic cardiopulmonary disease without an effective therapeutic approach. The underlying molecular mechanism of PAH remains largely unexplored at single-cell resolution. Methods Single-cell RNA sequencing (scRNA-seq) data from the Gene Expression Omnibus (GEO) database (GSE210248) was included and analyzed comprehensively. Additionally, microarray transcriptome including 15 lung tissue patients 11 normal samples...
Hepatocellular carcinoma (HC) has emerged as one of the most prevalent malignancies on a global scale. Recently, immunotherapy achieved favorable effectiveness in management multiple cancers. However, there are limited therapeutic options for advanced HC. As liver is special immune organ, we intend to uncover potential and effective immunotherapeutic modalities Our study was designed develop specific immune-related miRNAs (IRMs) outcome assessment individualized strategies HC.The miRNA-seq...