A5001645864- Diabetes and associated disorders
- Diabetes Management and Research
- Sexual Differentiation and Disorders
- Thyroid Disorders and Treatments
- Pancreatic function and diabetes
- Vitamin D Research Studies
- Diet, Metabolism, and Disease
- Birth, Development, and Health
- Thyroid Cancer Diagnosis and Treatment
- Obesity, Physical Activity, Diet
- Hormonal Regulation and Hypertension
- Metabolism and Genetic Disorders
- Nutritional Studies and Diet
- Hormonal and reproductive studies
- Human Health and Disease
- Growth Hormone and Insulin-like Growth Factors
- Adrenal Hormones and Disorders
- Child and Adolescent Health
- Immunodeficiency and Autoimmune Disorders
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Gestational Diabetes Research and Management
- Digestive system and related health
- Connexins and lens biology
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Sarcoma Diagnosis and Treatment
University of Split
2014-2024
University Hospital Centre Zagreb
2016-2017
Klinički Bolnički Centar Split
2007-2016
The aims of this study were to evaluate: (1) associations vitamin D with the presence/severity Hashimoto’s thyroiditis (HT) and (2) correlations thyroid-related phenotypes. Total 25(OH)D (vitamin in text) was measured from stored serum samples 461 HT patients 176 controls a Croatian Biobank (CROHT). Vitamin levels, proportions deficiency, compared between cases controls. additionally divided into two groups (MILD OVERT) take account severity. Correlations 10 clinical phenotypes all subgroups...
The incidence of type 1 diabetes mellitus (T1DM) among children and adolescents increased during the last 50 yr. T1DM in Croatia was 8.87/100.000/yr over 1995-2003, with an annual increase 9%, which placed countries moderate risk for T1DM.To investigate rates trends from 2004 to 2012 0 14-yr-old Croatian children, compare results previous studies other European countries.T1DM crude are estimated entire group three subgroups: 0-4, 5-9, 10-14 Standardized is calculated using method direct...
Catestatin is a chromogranin A-derived peptide with wide spectrum of biological activities, such as inhibiting catecholamine release, decreasing blood pressure, stimulating histamine reducing beta-adrenergic stimulation, and regulating oxidative stress.The aims our study were to determine serum catestatin concentrations in obese children adolescents regard presence or absence metabolic syndrome (MS) evaluate the possible relations between levels other cardiovascular risk factors.Ninety-two...
Hashimoto's thyroiditis (HT) is the most common form of autoimmune thyroid disorders characterized by lower production hormones and positivity to autoantibodies thyroglobulin (TgAb) and/or peroxidase (TPOAb). We performed a comprehensive phenotypic characterization patients with HT, specific focus on autoimmunity, get better understanding disease manifestation.We collected information thyroid-specific phenotypes (TSH, T3, T4, fT4, TgAb, TPOAb, volume) other clinical (age, body surface area,...
Introduction Vitamin D insufficiency is a global health problem affecting healthy and diseased individuals, including patients with Hashimoto’s thyroiditis (HT). Identifying dietary factors that may affect vitamin levels providing guidelines accordingly can alleviate this problem. We therefore aimed to identify still unknown associations of patterns, assessed through the Food Frequency Questionnaire (FFQ) blood levels. Materials methods FFQ was collected from 459 Croatian Biobank Patients...
Obesity and metabolic syndrome (MS) are one of the biggest public health issues in child adolescent population. To best authors’ knowledge, this hospital based study is first report on prevalence MS obese children adolescents Dalmatia, Mediterranean part Croatia. The objectives were to determine individual cardiovascular risk factors MS. Between January 2009 June 2014, 201 subjects aged 6 18 analyzed retrospectively from our Pediatric Endocrine Unit database. then classified two groups...
Abstract Background Although environmental factors induce development of type 1 diabetes mellitus (T1DM) in genetically susceptible individuals, many those have been uncovered. Therefore, the aim present study was to analyze associations T1DM with a wide range factors. Material and Methods A case-control conducted on 249 diabetic 255 healthy individuals from Dalmatian region South Croatia. Data regarding risk during pregnancy early life period child were evaluated. Results History...
The aim of the study was to determine clinical and biochemical characteristics type 1 diabetes mellitus (DM) at presentation in children younger than 15 years Croatia during a 9-year period, with special attention diabetic ketoacidosis (DKA) incidence. registered data set comprised blood glucose, pH, serum bicarbonate levels, symptoms disease manifestation. During 692 were diagnosed DM. Polydipsia (96.7%), polyuria (96.05%), weight loss (82.7%) most frequent anticipating detection. Enuresis...
Abstract Thyroid antibodies against thyroglobulin (TgAb) and thyroid peroxidase (TPOAb) are key markers of Hashimoto’s thyroiditis (HT), the most common autoimmune disorder. Genetic determinants still poorly known, especially as they were not studied in patients with diseases. We performed first genome-wide association analysis 430 HT that may be considered population extremes for distribution. detected two suggestively associated genetic variants TgAb, rs6972286 close to ANKRD7 LSM8 (P =...
Congenital adrenal hyperplasia (CAH) owing to 21-hydroxylase deficiency (21-OHD) is the most common inherited defect of steroid biosynthesis. At least 36 mutations in CYP21 gene, which mapped chromosome 6p21.3, have been described. We performed genetic analysis gene a patient with classic 21-OHD CAH and her family. The entire exonic coding regions intronic regions, as well -1 kb 5' upstream promoter region, were thoroughly sequenced analyzed. Despite extensive sequencing, no mutation was...
Background: Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy (APECED) is a rare monogenetic autosomal recessive disorder caused by mutation in the autoimmune regulator (AIRE) gene characterized complex phenotypic characteristics discovered over years of follow-up. Methods: 7 patients were recruited this case series period last 37 from Southern Croatia. All screened for AIRE R257X mutations. Results: This study group had mean current age 25.3 (age range 5.4 to 40.2 years), while...
Thyroid volume of Hashimoto's thyroiditis (HT) patients varies in size over the course disease and it may reflect changes biological function thyroid gland. Patients with subclinical hypothyroidism predominantly have increased whereas more pronounced smaller volumes. Suggested mechanism for atrophy is thyrocyte death due to apoptosis. We performed first genome-wide association study (GWAS) two groups HT patients, depending on levothyroxine (LT4) therapy, then meta-analysed across. Study...
Vitamin D deficiency is associated with a range of chronic diseases, including childhood obesity. Prevalence vitamin in obese children and adolescents ranges from 6.5% to 57%. This cross-sectional study included 92 patients body mass index z-score >2 39 subjects the control group. Anthropometric laboratory patient assessment were performed, fasting 25-hydroxyvitamin (25(OH)D). Adherence Mediterranean diet was assessed by Diet Quality Index for (KIDMED index), while physical activity...