A5011626312- Cardiovascular and Diving-Related Complications
- High Altitude and Hypoxia
- DNA Repair Mechanisms
- Ubiquitin and proteasome pathways
- Endoplasmic Reticulum Stress and Disease
- Autism Spectrum Disorder Research
- NF-κB Signaling Pathways
- Vitamin D Research Studies
- Cardiovascular and exercise physiology
- Diabetes and associated disorders
- Genetic factors in colorectal cancer
- Venous Thromboembolism Diagnosis and Management
- Genomics and Chromatin Dynamics
- Child Nutrition and Feeding Issues
- Spaceflight effects on biology
- Molecular Biology Techniques and Applications
- Heart Rate Variability and Autonomic Control
- Neuroscience of respiration and sleep
- Obstructive Sleep Apnea Research
- Cholinesterase and Neurodegenerative Diseases
- Cancer-related Molecular Pathways
- Tendon Structure and Treatment
- Immune cells in cancer
- Systemic Lupus Erythematosus Research
- Hepatitis C virus research
University of Split
2004-2024
University of California, San Diego
2008
Ruijs-Aalfs syndrome is a segmental progeroid resulting from mutations in the SPRTN gene. Cells derived patients with elicit genomic instability and people afflicted this developed hepatocellular carcinoma. Here we describe molecular mechanism by which contributes to genome stability normal cellular homeostasis. We show that DNA-dependent mammalian protease required for resolving cytotoxic DNA-protein crosslinks (DPCs)— function had only been attributed metalloprotease Wss1 budding yeast....
The purpose of this study was 1) to answer whether the reduction in spleen size breath-hold apnea is an active contraction or a passive collapse secondary reduced splenic arterial blood flow and 2) monitor response repeated apneas. Ten trained divers 10 intact 7 splenectomized untrained persons five maximal apneas (A1-A5) with face immersion cold water, 2 min interposed between successive attempts. Ultrasonic monitoring noninvasive cardiopulmonary measurements were performed before, apneas,...
We have previously shown in a rat model that single bout of high-intensity aerobic exercise 20 h before simulated dive reduces bubble formation and after the protects from lethal decompression sickness. The present study investigated importance these findings man. Twelve healthy male divers were compressed hyperbaric chamber to 280 kPa at rate 100 min(-1) breathing air remaining pressure for 80 min. ascent was 9 m with 7 min stop 130 kPa. Each diver underwent two randomly assigned dives, or...
Purpose: A similar postexercise hypotension (PEH) has been reported in sedentary and mildly endurance-trained individuals of both sexes after a single dynamic submaximal exercise. In men, the was associated with reduction cardiac output, whereas peripheral vasodilatation main mechanism this fall other groups. The present study investigated occurrence mechanisms PEH short maximal exercise professional soccer players greater endurance capacity than previously studies. Methods: Arterial blood...
Nerolidol is a naturally occurring sesquiterpene alcohol with multiple properties, including antioxidant, antibacterial, and antiparasitic activities. A few studies investigating the antitumor properties of nerolidol have shown positive results in both cell culture mouse models. In this study, we investigated mechanism cis-nerolidol bladder carcinoma lines. The our experiments on two lines revealed that inhibited proliferation induced distinct death pathways. We confirmed induces DNA damage...
Abstract DNA-protein crosslinks (DPCs), formed by the covalent conjugation of proteins to DNA, are toxic lesions that interfere with DNA metabolic processing and transcription. The development an accurate biochemical assay for DPC isolation is a priority mechanistic understanding their repair. Here, we propose STAR direct quantification DPCs, sensitive physiologically relevant treatment conditions. Implementing revealed formation small cross-linked peptides on created proteolytic degradation...
Mismatch repair (MMR) corrects replication errors during DNA synthesis. The mammalian MMR proteins also activate cell cycle checkpoints and apoptosis in response to persistent damage. MMR-deficient cells are resistant cisplatin, a cross-linking agent used chemotherapy, because of impaired activation apoptotic pathways. It is shown that postmeiotic segregation 2 (PMS2), an protein, required for cisplatin-induced p73, member the p53 family transcription factors with proapoptotic activity....
Several genes and their single nucleotide polymorphisms (SNPs) are associated with either spontaneous resolution of hepatitis C infection or better treatment-induced viral clearance. We tested a cohort intravenous drug users (IVDU) diagnosed chronic virus (HCV) for treatment response its association the SNPs in interleukin-6 (rs1800795-IL6) interleukin-28B (rs12979860-IL28B) genes.The study included 110 Croatian IVDU positive anti-HCV antibody. Genotyping was performed by polymerase chain...
To evaluate the cardiopulmonary effects of open sea scuba air diving to 39 m (30 minutes bottom time) with standard decompression. account for possible gravity dependent venous gas bubbles, variables were measured in different post-dive body postures and compared baseline values before dive same posture.Eight male divers conducted two similar dives on successive days. Their posture after was either sitting or supine, random order. The evaluated 30, 60, 90 dive. Venous bubbles detected by...
Idiopathic carpal tunnel syndrome (ICTS) is a common entrapment neuropathy. Some cases of ICTS are linked to mutations the transthyretin gene, whereas others associated with systemic amyloidosis. The majority unknown etiology.To study molecular mechanisms development.A total 71 patients and 68 control subjects were included in study. fibrinogen level was determined before surgery its deposition transversal ligament (TCL) detected by immunohistochemistry, Western blot, mass spectrometry....
Histones are an essential part of nucleosomes that regulate chromatin structure and function. Histone exchanges modifications represent a scaffold for DNA transcription, repair, replication. Studying histones histone code is important fast-developing branch epigenetic science. Here we propose fast, efficient, versatile assay nucleosomal isolation from mammalian cells, without the use acids or high salt solutions which common other techniques. All components used in protocol inexpensive...