A5074098219- Dialysis and Renal Disease Management
- Neonatal Health and Biochemistry
- Urinary Tract Infections Management
- Bladder and Urothelial Cancer Treatments
- Gut microbiota and health
- Muscle and Compartmental Disorders
- Pediatric Urology and Nephrology Studies
- Ubiquitin and proteasome pathways
- interferon and immune responses
- Epigenetics and DNA Methylation
- Central Venous Catheters and Hemodialysis
- Renal function and acid-base balance
- Diet, Metabolism, and Disease
- Cytokine Signaling Pathways and Interactions
- NF-κB Signaling Pathways
- Renal and related cancers
- Genetic Associations and Epidemiology
- Metabolism and Genetic Disorders
- Pharmacological Effects and Toxicity Studies
- Diabetes and associated disorders
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Vitamin D Research Studies
- Polyamine Metabolism and Applications
- Urinary Bladder and Prostate Research
- Child Nutrition and Feeding Issues
University of Split
2013-2025
Université de Strasbourg
2024
Hôpitaux Universitaires de Strasbourg
1997-2018
Hôpital d'Hautepierre
1993-2016
University of California, San Diego
2009-2010
Mediterranean Institute for Life Sciences
2009
Max Planck Institute for Biology
2000
Aleksandër Moisiu University
1998
University of Zagreb
1996
Aggregation of misfolded proteins and the associated loss neurons are considered a hallmark numerous neurodegenerative diseases. Optineurin is present in protein inclusions observed various diseases including amyotrophic lateral sclerosis (ALS), Huntington's disease, Alzheimer's Parkinson's Creutzfeld-Jacob disease Pick's disease. deletion mutations have also been described ALS patients. However, role optineurin mechanisms aggregation remains unclear. In this report, we demonstrate that...
Recent findings suggest that human microbiome can influence the development of cancer, but role microorganisms in bladder cancer pathogenesis has not been explored yet. The aim this study was to characterize and compare urinary patients with those healthy controls. Bacterial communities present urine specimens collected from 12 male diagnosed 11 healthy, age-matched individuals were analysed using 16S sequencing. Our results show most abundant phylum both groups Firmicutes, followed by...
Exposure to environmental pollutants and human microbiome composition are important predisposition factors for tumour development
Ruijs-Aalfs syndrome is a segmental progeroid resulting from mutations in the SPRTN gene. Cells derived patients with elicit genomic instability and people afflicted this developed hepatocellular carcinoma. Here we describe molecular mechanism by which contributes to genome stability normal cellular homeostasis. We show that DNA-dependent mammalian protease required for resolving cytotoxic DNA-protein crosslinks (DPCs)— function had only been attributed metalloprotease Wss1 budding yeast....
Background. In children, growth can be used as a measurable parameter of adequate nutrition and dialysis dose. Despite daily administration recombinant human hormone (rhGH), retardation remains frequent problem in children on chronic dialysis. Therefore, we performed an observational prospective non-randomized study in-centre line haemodiafiltration (D-OL-HDF) with the aim promoting growth. Patients methods. Mean age at start was 8 years 3 months, all had been receiving rhGH treatment for...
Factors underlying genetic predisposition for development of sporadic colorectal cancer are largely unknown. The fact that this is more common in patients suffering from inflammatory bowel disease raises the question relationship between chronic inflammation and cancer. Toll‐like receptors 2 (TLR2) 4 (TLR4) critical initiating innate immune response toward various bacteria commonly found intestine. Recent evidence about association polymorphisms these genes with ulcerative colitis Crohn’s...
Despite major improvements in paediatric dialysis over the last two decades, cardiovascular outcome is often poor. As France gives priority to kidney transplantation dialysis, children chronic haemodialysis are generally pre-adolescents or adolescents with long medical histories and low compliance. In them, usual weekly schedule of unsuitable. We conducted a study conversion daily which allowed an enhanced dose, gentle ultrafiltration rate achievement dry body weight.In this single-centre,...
Bladder cancer (BC) is the most common malignant disease of urinary tract. Recurrent high grade non muscle invasive BC carries a serious risk for progression and subsequent metastases. The preclinical mouse model bladder relies on administration N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN) to mice. BBN-induced tumors in mice recapitulate histology human were characterized with an overexpression markers typical basal-like subtype addition mutational burden frequent mutations Trp53, similar...
The gold standard for treating high-risk non-muscle-invasive bladder cancer involves the transurethral removal of cancerous tissue followed by BCG immunotherapy. So far, there is no reliable biomarker predicting efficacy and identifying patients who will or not respond to treatment. Emerging evidence suggests that urinary microbiota may play a crucial role in efficacy. This study aimed explore (i) changes during six induction cycles (ii) its potential predictive determining outcome To this...
Pterygium is a condition affecting the ocular surface, marked by triangular-shaped growth of fibrotic tissue extending from nasal conjunctiva toward corneal center, potentially causing visual impairment. While ultraviolet (UV )light exposure primary risk factor for pterygium, its underlying cause remains unclear. In order to better understand true genesis pterygium development, we investigated and compared it with healthy controls. Given eye's direct environmental exposure, analyzed...
The aim of this study was to examine the antioxidant capacity curcumin and whether it modulates RA-induced oxidative stress. Pro-oxidants from plasma coronary venous effluent were determined spectrophotometrically. concentration nitrite significantly lower in treated group compared disease (p < 0.05), while concentrations superoxide anion radical, hydrogen peroxide lipid peroxidation index group, but without statistical significance between groups. Curcumin has a beneficial effect...
It is generally accepted that living jawless vertebrates (lampreys and hagfishes) lack the capability of mounting an adaptive immune response. At same time, however, there are reports describing histological evidence for presence in agnathan tissues lymphocytes, key players immunity. The question therefore arises whether cells identified morphologically as lymphocytes true terms their genetic developmental program. In this study, provided lampreys express a member purine box 1 ( PU .1...