A5045370846- Retinal Diseases and Treatments
- Glaucoma and retinal disorders
- Retinal Imaging and Analysis
- Retinal and Optic Conditions
- Retinal Development and Disorders
- Intraocular Surgery and Lenses
- Corneal surgery and disorders
- melanin and skin pigmentation
- Bee Products Chemical Analysis
- Ocular Oncology and Treatments
- Diabetes and associated disorders
- Ophthalmology and Visual Impairment Studies
- Connexins and lens biology
- Regional Development and Management Studies
- Traumatic Ocular and Foreign Body Injuries
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Ocular Infections and Treatments
- Acute Ischemic Stroke Management
- Nutrition, Genetics, and Disease
- Cancer Diagnosis and Treatment
- Advanced Glycation End Products research
- Essential Oils and Antimicrobial Activity
- Retinal and Macular Surgery
- Genetic Associations and Epidemiology
- History of Medicine Studies
University of Split
2015-2025
Klinički Bolnički Centar Split
2008-2022
University Hospital Centre Zagreb
2022
Central corneal thickness (CCT) is a highly heritable trait, which has been proposed to influence disorders of the anterior segment eye. A genome-wide association study (GWAS) CCT was performed in 2269 individuals from three Croatian and one Scottish population. In discovery set (1445 individuals), two significant associations were identified for single nucleotide polymorphisms rs12447690 (β = 0.23 SD, P 4.4 × 10−9) rs1536482 0.22 7.1 10−8) closest candidate genes (although ≥90 kb away) zinc...
To study the epidemiology of ocular trauma requiring hospital admission in children under 18 years age.This retrospective cohort included pediatric patients with injuries at Ophthalmology Department Clinical Hospital Centre, Split, Croatia, from 2000 to 2015, classified according Birmingham Eye Trauma Terminology.There were 353 hospitalized, 82% boys (mean age 11 years) and 18% girls 10 years). The majority traumas occurred outside environment (70%, n = 249), followed by occurrences home...
Propolis is one of the richest sources plant phenolics (flavonoids and phenolic acids), which are widely recognized as rather strong antioxidants. The aim our work was to use colored stable free radical (DPPH· ABTS·+) spectrophotometric thin-layer chromatographic (TLC) assays study antioxidative behavior (caffeic acid, galangin pinocembrin) most commonly present in Croatian propolis samples obtained from different regions. We propose a mathematical model providing more sophisticated...
Pterygium is a condition affecting the ocular surface, marked by triangular-shaped growth of fibrotic tissue extending from nasal conjunctiva toward corneal center, potentially causing visual impairment. While ultraviolet (UV )light exposure primary risk factor for pterygium, its underlying cause remains unclear. In order to better understand true genesis pterygium development, we investigated and compared it with healthy controls. Given eye's direct environmental exposure, analyzed...
The aim was to estimate association of the oxidative stress with occurrence age-related macular degeneration (AMD). activities erythrocyte antioxidant enzymes: superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase (CAT) additionally serum total status (TAS) were used as indicators level. 57 AMD patients (32 early 25 late AMD) 50 healthy, age gender matched controls included. GPx activity (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"...
Purpose.: To assess the effects of body stature and years education, in addition to age sex, on six oculometric traits estimate heritabilities these quantitative two Croatian cross-population studies. Methods.: Adult subjects living islands Vis Korčula were recruited for a large epidemiologic genetic study that included eye biometry, keratometry, autorefraction. Effects estimated by using general linear mixed models axial length (AL), anterior chamber depth (ACD), corneal curvature (CC),...
AimTo define the Y-chromosome genetic structure in a sample of men from southern Croatia.MethodsBlood samples were collected 166 unrelated healthy Croatia at Department Forensic Medicine and Biochemical Laboratory University Hospital Split between 2004 2007. Genomic DNA was extracted using standard procedures. Seventeen short tandem repeat (Y-STR) polymorphic loci (DYS456, DYS389I, DYS390, DYS389II, DYS458, DYS19, DYS385, DYS393, DYS391, DYS439, DYS635, DYS392, GATAH4, DYS437, DYS438,...
AimTo study the association between genetic variants in myocilin and collagen type I alpha 1 genes high myopia an isolated island population.MethodsA total of 944 examinees from epidemiology conducted on Korčula, Croatia, were included study. We selected 2 short nucleotide polymorphisms (SNP) available our genome-wide scan set SNPs that previously associated with used them to replicate previous claims possible association.ResultsNineteen cases myopia, defined as refraction ≤-6.00 diopters,...
BACKGROUND:The aim of the present study was to investigate relationship between personality traits, stress, emotional intelligence, and central serous chorioretinopathy (CSCR). MATERIAL AND METHODS:This prospective case-control included 57 patients with acute CSCR age- sex-matched controls refractive errors. Inclusion criteria for group were unilateral onset visual disturbances within 2 weeks until first visit ophthalmologist ophthalmoscopic finding a round or oval macular detachment...
To assess long-term structural and functional outcomes of intravitreal aflibercept (Eylea®) treatment for neovascular macular degeneration (nAMD) in a real-word setting.This was retrospective, single-centre, non-randomized interventional cohort analysis. Data from treatment-naive patients with nAMD funded the period between 1 September 2013 28 February 2014 who finished 4-year follow-up entered Epidemiological data, visual acuity (VA) measured on ETDRS charts injection numbers were recorded....
Introduction Pterygium is a non-cancerous growth of the conjunctival tissue over cornea that may lead to visual impairment in advanced stages, restriction ocular motility, chronic inflammation and cosmetic concerns. Surgical removal treatment choice, but recurrence pterygium frequent problem. It has been previously shown fibrin glue result less take time than sutures for fixing graft place during surgery. However, biological material it carries risk transmitting infectious agents from pooled...
Isolation is a known force in evolutionary biology and one of the main factors speciation. One consequences severe isolation reduced mate choice, which results occurrence inbreeding as result isolation. We investigated effects individual genome-wide heterozygosity measured multilocus (MLH) on biochemical markers hemostasis inflammation 1,041 individuals from island Vis, Croatia, where prevalent wide range variation expected. Assessment was based scans using 800 microsatellite (STR) 317,503...
Diabetic retinopathy is one of the leading causes blindness. We estimated prevalence diabetic among a population in Dubrovnik-Neretva County Republic Croatia and searched for potential risk factors.A prospective study was performed with 600 patients from different parts who attended regular medical ophthalmological check-ups at General Hospital Dubrovnik September 2014 to 2015. Patients underwent complete assessment by two ophthalmologists. Retinal examination included evaluation presence...
The pathogenesis of age-related macular degeneration (AMD) remains elusive, despite numerous research studies. Therefore, we aimed to investigate the changes plasma and IgG-specific N-glycosylation across disease severity spectrum. We examined 2835 subjects from 10.001 Dalmatians project, originating isolated Croatian islands Vis Korčula. All were classified into four groups, namely (i) bilateral AMD, (ii) unilateral (iii) early-onset drusen, (iv) controls. analysed IgG N-glycans measured by...
The authors present a rare case of acute bilateral cataract with phacomorphic glaucoma in girl newly diagnosed type 1 diabetes mellitus without known history ocular problems. Within 3 months after the diagnosis mellitus, she presented high intraocular pressure. Her visual acuity was limited to hand motions. patient required immediate surgical intervention. Postoperatively, pressure normalized and 6/6.