A5063599280- Colorectal Cancer Screening and Detection
- Genetic factors in colorectal cancer
- Digestive system and related health
- Genetic Associations and Epidemiology
- Gastric Cancer Management and Outcomes
- Cancer Risks and Factors
- Liver Disease Diagnosis and Treatment
- Helicobacter pylori-related gastroenterology studies
- Gut microbiota and health
- Multiple and Secondary Primary Cancers
- Nutrition, Genetics, and Disease
- Estrogen and related hormone effects
- Colorectal Cancer Surgical Treatments
- Cancer, Lipids, and Metabolism
- BRCA gene mutations in cancer
- Nutrition and Health in Aging
- Genetics and Neurodevelopmental Disorders
- Cancer Immunotherapy and Biomarkers
- Macrophage Migration Inhibitory Factor
- Esophageal Cancer Research and Treatment
- Alcohol Consumption and Health Effects
- Bioinformatics and Genomic Networks
- Adenosine and Purinergic Signaling
- Radiomics and Machine Learning in Medical Imaging
- Endoplasmic Reticulum Stress and Disease
Jinan University
2024-2025
Heidelberg University
2019-2024
German Cancer Research Center
2021-2024
University Hospital Heidelberg
2019-2024
Cancer Research Center
2021
Background: Accumulating evidence has shown that disorders in the gut microbiota and derived metabolites affect development of atherosclerotic cardiovascular disease (ASCVD). However, which how specific microbial contribute to progression atherosclerosis clinical relevance their alterations remain unclear. Methods: We performed integrated microbiome–metabolome analysis 30 patients with coronary artery (CAD) age- sex-matched healthy controls identify CAD-associated metabolites, were then...
Background & AimsIncidence of colorectal cancer (CRC) in younger adults is increasing many countries. Given the established association body mass index (BMI) with CRC risk and obesity prevalence among generations, we aimed to evaluate BMI at different ages during early adulthood early-onset CRC.MethodsAmong 6602 patients 7950 matched controls who were recruited 2003-2020 Darmkrebs: Chancen der Verhütung durch Screening study, a population-based case–control study from Germany, 747 621 than...
Evidence is lacking on the impact of alcohol consumption colorectal cancer (CRC) risk (overall and by age at diagnosis) polygenic score (PRS) levels, it unclear how magnitude CRC associated with compares to genetically determined risk.Multiple logistic regression was used assess association between across PRS levels based 140 CRC-related loci among 5104 cases 4131 controls from a large population-based case-control study. We compared effects for using "Genetic Risk Equivalent (GRE)"...
Abstract Background Incidence of colorectal cancer (CRC) in younger adults is increasing many countries. Smoking an established risk factor CRC risk, but evidence on its impact early-onset (EOCRC) limited. We aimed to evaluate the association smoking exposure with EOCRC and compare it late-onset (LOCRC). Methods history other known or suspected factors were ascertained detail personal interviews among 6264 patients 6866 controls (frequency matched for age, sex, county residence) who...
Smoking and genetic predisposition are established risk factors for colorectal cancer (CRC). We aimed to assess compare their individual joint impact on CRC using the novel approach of equivalent (GRE).Data were extracted from Darmkrebs: Chancen der Verhütung durch Screening study, a large population-based case-control study in Germany. A polygenic score (PRS) based 140 CRC-related single nucleotide polymorphisms was derived quantify risk. Multiple logistic regression used estimate smoking...
Excess weight is an established risk factor of colorectal cancer (CRC). However, evidence lacking on how its impact varies by polygenic at different stages carcinogenesis.
Abstract Background Obesity is an established risk factor for colorectal cancer (CRC), but the evidence association inconsistent across molecular subtypes of disease. Methods We pooled data on body mass index (BMI), tumor microsatellite instability status, CpG island methylator phenotype BRAF and KRAS mutations, Jass classification types 11 872 CRC cases 013 controls from observational studies. used multinomial logistic regression to estimate odds ratios (OR) 95% confidence intervals (CI)...
Objective: We aimed to directly compare the estimated effects of adherence a healthy lifestyle with those risk predisposition according known genetic variants affecting colorectal cancer (CRC) risk, support effective communication for prevention. Methods: A score (HLS) was derived from 5 factors: smoking, alcohol consumption, diet, physical activity, and body adiposity. The association polygenic (PRS) (based on 140 CRC-associated loci) CRC assessed multiple logistic regression compared...
Abstract Background Menopausal hormone therapy (MHT), a common treatment to relieve symptoms of menopause, is associated with lower risk colorectal cancer (CRC). To inform CRC prediction and MHT risk-benefit assessment, we aimed evaluate the joint association polygenic score (PRS) for on risk. Methods We used data from 28,486 postmenopausal women (11,519 cases 16,967 controls) European descent. A PRS based 141 CRC-associated genetic variants was modeled as categorical variable in quartiles....
Background & AimsPolygenic risk scores (PRSs) could help to define personalized colorectal cancer (CRC) screening strategies. The aim of this study was evaluate whether a PRS, along with adenoma characteristics, more and risk-adapted surveillance intervals.MethodsIn population-based, case-control from Germany, detailed information on previous colonoscopies PRS based 140 CRC-related, single-nucleotide polymorphisms obtained 4696 CRC cases 3709 controls. Participants were classified as having...
Diabetes is an established risk factor for colorectal cancer. However, the mechanisms underlying this relationship still require investigation and it not known if association modified by genetic variants. To address these questions, we undertook a genome-wide gene-environment interaction analysis.
Summary Background The regular use of non‐steroidal anti‐inflammatory drugs (NSAIDs) has been associated with reduced colorectal cancer (CRC) risk. Aim To explore whether this association varies according to background polygenic risk for CRC. Methods Data were collected from a large population‐based case‐control study on CRC in Germany. A score (PRS) based 140 CRC‐related loci was used quantify the genetic associations NSAIDs (≥2times per week at least 1 year) estimated whole population and...
High red and processed meat intake (RPMI) is an established risk factor for colorectal cancer (CRC). We aimed to assess the impact of RPMI on CRC according in comparison with genetically determined risk, which was quantified by a polygenic score (PRS). potential confounders (ascertained questionnaire) PRS (based 140 CRC-related loci) were obtained from 5109 cases 4134 controls population-based case−control study. Associations across levels assessed using logistic regression models compared...
Colorectal cancer risk can be impacted by genetic, environmental, and lifestyle factors, including diet obesity. Gene-environment interactions (G × E) provide biological insights into the effects of obesity on colorectal risk. Here, we assessed potential genome-wide G E between body mass index (BMI) common SNPs for using data from 36,415 cases 48,451 controls three international consortia (CCFR, CORECT, GECCO). The tests included conventional logistic regression multiplicative terms (one...
Abstract Introduction Whether and to what extent the relationship between physical activity (PA) colorectal cancer (CRC) differs according CRC‐related genetic risk remains be determined, no studies date have quantified how much genetically determined could compensated for with active exercise. Methods Genetic was by a polygenic score (PRS) summarizing estimated effect of 140 CRC‐associated variants. Associations PA CRC were multivariable logistic regression across PRS levels. We also...
Excess weight, the prevalence of which is high and increasing in many countries, linked to multiple adverse health outcomes, including increased colorectal cancer (CRC) risk. Better communication risks associated with excess weight might support efforts prevention.To evaluate individual joint associations body mass index (BMI) polygenic risk CRC, assess potential interactions among them, quantify by how much for CRC can be offset having a BMI within reference range.This population-based...
Colorectal cancer (CRC) incidence and mortality are higher among men than women. We aimed to estimate overall age-specific risk advancement periods (RAPs) for compared women, which quantify how many years earlier comparable levels of reached by men. RAPs were derived Cox regression models 331 224 participants aged 40 69 at baseline the UK Biobank with no previous diagnosis CRC screening examination who followed respect up 13 years. Men substantially women in age groups 50 59 60 69, (95%...
Importance Colorectal cancer (CRC) risk varies widely in the population at average without a family history, but there are no established routines for translating this variation into personalized starting ages of screening. Objective To illustrate derivation risk-adapted CRC screening based on concept advancement period (RAP) using sex and polygenic score (PRS) as an example. Design, Setting, Participants This cohort study included participants UK Biobank recruited England, Wales, Scotland...
High red and processed meat intake genetic predisposition are risk factors of colorectal cancer (CRC). However, evidence their independent joint associations on the neoplasms is limited. We assessed these among 4774 men women undergoing screening colonoscopy. Polygenic scores (PRSs) were calculated based 140 loci related to CRC. used multiple logistic regression models evaluate PRS with neoplasms. Adjusted odds ratios (aORs) translated equivalents (GREs) compare strength neoplasm both...