A5015854861- Colorectal Cancer Screening and Detection
- Nutrition and Health in Aging
- Cancer survivorship and care
- Genetic factors in colorectal cancer
- Frailty in Older Adults
- Nutritional Studies and Diet
- Gastric Cancer Management and Outcomes
- Cancer, Lipids, and Metabolism
- Childhood Cancer Survivors' Quality of Life
- Colorectal Cancer Treatments and Studies
- Helicobacter pylori-related gastroenterology studies
- Obesity, Physical Activity, Diet
- Genetic Associations and Epidemiology
- Multiple and Secondary Primary Cancers
- Inflammatory mediators and NSAID effects
- Chronic Disease Management Strategies
- BRCA gene mutations in cancer
- Colorectal Cancer Surgical Treatments
- Infant Nutrition and Health
- Dye analysis and toxicity
- Body Composition Measurement Techniques
- Cancer, Stress, Anesthesia, and Immune Response
- Nutrition, Genetics, and Disease
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Health Systems, Economic Evaluations, Quality of Life
Heidelberg University
2015-2023
German Cancer Research Center
2015-2023
Monash University
2021-2023
Australian Regenerative Medicine Institute
2021-2023
Neuroscience Research Australia
2022
Health Sciences and Nutrition
2020-2021
DKFZ-ZMBH Alliance
2019-2020
Institute of Aging
2017
Estimates of absolute risk colorectal cancer (CRC) are needed to facilitate communication and better inform the public about potentials limits prevention.Using data from a large population-based case-control study in Germany (Darmkrebs: Chancen der Verhütung durch Screening [DACHS] study, which began 2003) population registry data, we calculated 30-year estimates for development CRC based on healthy lifestyle score (derived 5 modifiable factors: smoking, alcohol consumption, diet, physical...
Smoking and alcohol increase risk for colorectal malignancies. However, cancer (CRC) is a heterogenic disease associations with the molecular pathological pathways are unclear.This population-based case-control study includes 2444 cases first-diagnosis CRC 2475 controls. Tumour tissue was analysed MSI (microsatellite instability), CIMP (CpG island methylator phenotype), BRAF (B-Raf proto-oncogene serine/threonine kinase gene) KRAS (Kirsten rat sarcoma viral oncogene homologue mutations. Odds...
Importance The association between weight change and subsequent cause-specific mortality among older adults is not well described. significance of changes in waist circumference (WC) has also been compared with for this purpose. Objective To examine the associations body WC all-cause mortality. Design, Setting, Participants This cohort study a post hoc analysis data from Aspirin Reducing Events Elderly (ASPREE) randomized clinical trial, which recruited participants March 1, 2010, December...
Abstract Background The laparoscopic sleeve gastrectomy (LSG) and the incisionless endoscopic gastroplasty (ESG) weight loss procedures require further investigation of their efficacy, safety patient-centered outcomes in Australian setting. Methods aim was to examine 6- 12-month safety, weight-related quality life (QoL) adults with obesity who received ESG or LSG bariatric procedure 12+ months adjuvant multidisciplinary pre- postprocedural support. Data were from a two-arm prospective cohort...
BackgroundUnderstanding the nature of transitions from a healthy state to chronic diseases and death is important for planning health-care system requirements interventions. We aimed quantify trajectories disease disability in population older people.MethodsWe conducted secondary analysis data ASPREE trial, which was done 50 sites Australia USA recruited community-dwelling, individuals who were aged 70 years or (≥65 Black Hispanic people USA) between March 10, 2010, Dec 24, 2014....
Regular use of aspirin and nonsteroidal anti-inflammatory drugs (NSAIDs) for a longer period has been inversely associated with colorectal cancer (CRC) risk. However, CRC is heterogenic disease, little known regarding the associations molecular pathological subtypes.Analyses included 2444 cases first diagnosis 3130 healthy controls from German population-based case control study. Tumor tissue samples were analyzed major features: microsatellite instability (MSI), CpG island methylator...
Abstract Prolonging survival in good health is a fundamental societal goal. However, the leading determinants of disability-free healthy older people have not been well established. Data from ASPREE, bi-national placebo-controlled trial aspirin with 4.7 years median follow-up, was analysed. At enrolment, participants were and without prior cardiovascular events, dementia or persistent physical disability. Disability-free outcome defined as absence dementia, disability death. Selection...
Objective: The aim of this study was to evaluate outcomes metastases at various time intervals after colorectal cancer (CRC) diagnosis. Background: Earlier studies have indicated a short interval between CRC diagnosis and distant be associated with poor prognosis. majority assessed outcome from or metastasis resection rather than might subject immortal bias. Methods: Patients in the population-based DACHS were stratified: at/within 1 month (immediate), 2 6 months (early), 7 12...
The risk of developing colorectal cancer (CRC) is associated with a wide range dietary and lifestyle factors. individual contribution single modifiable factors, such as alcohol consumption, physical activity, smoking, body mass index (BMI) or components, to the development CRC has been investigated extensively, but evidence on their combined effect at various stages carcinogenesis sparse. aim our study was analyze association healthy pattern prevalence early advanced neoplasms. A total...
Objective: We aimed to directly compare the estimated effects of adherence a healthy lifestyle with those risk predisposition according known genetic variants affecting colorectal cancer (CRC) risk, support effective communication for prevention. Methods: A score (HLS) was derived from 5 factors: smoking, alcohol consumption, diet, physical activity, and body adiposity. The association polygenic (PRS) (based on 140 CRC-associated loci) CRC assessed multiple logistic regression compared...
Background & AimsPolygenic risk scores (PRSs) could help to define personalized colorectal cancer (CRC) screening strategies. The aim of this study was evaluate whether a PRS, along with adenoma characteristics, more and risk-adapted surveillance intervals.MethodsIn population-based, case-control from Germany, detailed information on previous colonoscopies PRS based 140 CRC-related, single-nucleotide polymorphisms obtained 4696 CRC cases 3709 controls. Participants were classified as having...
Zusammenfassung Übergewicht und Adipositas sind bedeutende Risikofaktoren für verschiedene Erkrankungen. Als Maß zu ihrer Bestimmung wurde in früheren Studien meist nur der Body-Mass-Index (BMI) verwendet. Der BMI ist allerdings ein Marker, den Einfluss auf das Krankheitsrisiko unzureichend erfasst. In groß angelegten, bevölkerungsbasierten besteht daher vordringlicher Bedarf, verbesserte Messmethoden Körperzusammensetzung -fettverteilung einzusetzen. vorliegende Beitrag stellt die NAKO...
Little is known about the mineral composition of pink salt. The aim this study was to evaluate for first time salt available purchase in Australia and its implications public health. Pink samples were purchased from retail outlets two metropolitan Australian cities one regional town. Color intensity, form, country origin coded. A mass spectrometry scan solids used determine amount 25 nutrients non-nutritive minerals (n = 31) an iodized white table control 1). wide variation type range across...
Abstract In the general population, body mass index (BMI) and waist circumference are recognized risk factors for several chronic diseases all-cause mortality. However, whether these associations same older adults is less clear. The association of baseline BMI with cause-specific mortality was investigated in 18,209 Australian US participants (mean age: 75.1 ± 4.5 years) from ASPirin Reducing Events Elderly (ASPREE) study, followed up a median 6.9 years (IQR: 5.7, 8.0). There were...
In previous studies, the protective effect of colonoscopy was generally stronger for distal colorectal cancer than proximal (CRC). This study aimed to investigate whether reduction CRC risk through varies according major tumor markers and pathways CRC.This is a population-based case-control from Germany, including 2,132 patients with first diagnosis information on molecular 2,486 control participants without CRC. Detailed participant characteristics were collected by standardized...