A5004143383- Liver Disease Diagnosis and Treatment
- Colorectal Cancer Screening and Detection
- Genetic Associations and Epidemiology
- Endoplasmic Reticulum Stress and Disease
- Nutrition, Genetics, and Disease
- Nutritional Studies and Diet
- Genetic factors in colorectal cancer
- Helicobacter pylori-related gastroenterology studies
- Health Systems, Economic Evaluations, Quality of Life
- Meat and Animal Product Quality
- Meta-analysis and systematic reviews
- Pancreatic and Hepatic Oncology Research
- Global Cancer Incidence and Screening
- Computational Drug Discovery Methods
- Digestive system and related health
- BRCA gene mutations in cancer
- Radiomics and Machine Learning in Medical Imaging
- Obesity, Physical Activity, Diet
- Immune Cell Function and Interaction
- Cancer Risks and Factors
- Adipokines, Inflammation, and Metabolic Diseases
- RNA modifications and cancer
- Diet and metabolism studies
- Genetic and phenotypic traits in livestock
- Mycobacterium research and diagnosis
Broad Institute
2024-2025
Fred Hutch Cancer Center
2013-2024
University of Washington
2013-2024
Sacred Heart University
2024
Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa
1996-2023
Cancer Research Center
1992-2023
Purdue University West Lafayette
2020-2023
Swansea University
2023
Center for Cancer Research
2020
World Bank
2016-2017
The authors divided 61 subjects with primary degenerative dementia of the Alzheimer's type into a group who also met DSM-III criteria for depression (N = 28) and did not 33). Both groups were randomly assigned to an 8-week double-blind trial imipramine or placebo. Scores on Hamilton Rating Scale Depression, administered at baseline weeks 2, 4, 6, 8, indicated significant improvement in both groups. Two measures cognitive function yielded differing results. results suggest that moderate is...
Screening MammographyClinical Image Quality and the Risk of Interval Breast CancerStephen H. Taplin1 2, Carolyn M. Rutter1, Charles Finder3, Margaret T. Mandelson1 4, Florence Houn5 Emily White4Audio Available | Share
OBJECTIVES: We hypothesized that belief in an association between diet and cancer, knowledge of dietary recommendations food composition, perceived norms would predict healthful changes. METHODS: Data are from a population-based sample Washington State residents (n = 607). Psychosocial constructs measured at baseline (1989/90) were used to changes practices, fat intake, fiber weight over 3 years. RESULTS: Adults who strongly believed diet-cancer connection decreased the percentage energy...
Chronic inflammation, which is associated with obesity, may play a role in the etiology of several diseases. Thus, reducing inflammation offer disease-prevention strategy, particularly among obese. Several modifiable factors have been including: dietary fiber intake, saturated fat physical activity, smoking, alcohol, and use certain supplements medications (glucosamine, chondroitin, fish oil, vitamin E, statins aspirin). To study whether these associations differ by body mass index (BMI), we...
Background Glucosamine and chondroitin are popular non-vitamin dietary supplements used for osteoarthritis. Long-term use is associated with lower incidence of colorectal lung cancers mortality; however, the mechanism underlying these observations unknown. In vitro animal studies show that glucosamine inhibit NF-kB, a central mediator inflammation, but no definitive trials have been done in healthy humans. Methods We conducted randomized, double-blind, placebo-controlled, cross-over study to...
OBJECTIVES: Time trends in breast cancer mortality were analyzed from 1970 to 1992 among White and Black US women aged 25 over. METHODS: Mortality data the National Center for Health Statistics summarized within three periods 1979, 1980 1988, 1989 1992. The annual change was calculated as average yearly percentage of based on logistic model. RESULTS: For all ages, decreased by 1.6% (95% confidence interval = -2.0%, -1.1%) per year during 1992, contrast flat rates observed 1970s a 0.5%...
Background: Mammography screening may reduce breast cancer mortality by detecting cancers at an earlier stage. However, certain questions remain, including the ideal interval between mammograms. Methods: We conducted observational study using information collected seven mammography registries across United States to investigate whether women diagnosed with after having mammograms separated a 2-year (n = 2440) are more likely be late-stage disease (positive lymph nodes or metastases) than...
Abstract Background: Biomarkers of low-grade systemic inflammation are used to study the associations with chronic diseases, including cancer. However, relatively little is known about intraindividual variability most these measures. Methods: Fasting serum samples, collected at baseline and end ≥3-week washout periods in a four-diet crossover feeding trial, were measure inflammatory markers high sensitivity C-reactive protein (hsCRP), interleukin (IL)-6, tumor necrosis factor (TNF)-α, IL-8,...
BackgroundMost cancers occur more frequently in men.Numerous explanations for this excess risk have been proposed, yet no study has quantified the degree to which height explains sex difference even though greater associated with increased many cancers. MethodsDuring period from 2000 2002, 65 308 volunteers aged 50 76 years were recruited Vitamins And Lifestyle (VITAL) study.Cancers of shared anatomic sites (n = 3466) prospectively identified through 2009 Surveillance, Epidemiology, and End...
Background: For men and women, taller height is associated with increased risk of all cancers combined. colorectal cancer (CRC), it unclear whether the differential association by sex real or due to confounding bias inherent in observational studies. We performed a Mendelian randomization study examine between CRC risk. Methods: To minimize bias, we derived weighted genetic score predicting (using 696 variants height) 10 226 cases 286 controls. Logistic regression was used estimate odds...
Glucosamine and chondroitin supplements have been shown to anti-inflammatory properties in both vitro studies animal models; however, little is known about these relationships humans. The VITamins Lifestyle (VITAL) biomarker study evaluated the associations between use of a panel circulating inflammatory biomarkers.Study participants included 217 men women age 50-75 years living Seattle metropolitan area. Use glucosamine was ascertained by home interview/supplement inventory. Inflammation...
While much is known about correlates of C-reactive protein (CRP), little other inflammation biomarkers. As these measures are increasingly being used in epidemiologic studies, it important to determine what factors affect biomarker concentrations.Using age, sex, and body mass index (BMI) adjusted linear regression, we examined 38 exposures (demographic anthropometric measures, chronic disease history, NSAIDs, dietary factors, supplement use) 8 biomarkers [CRP, IL1β, IL6, IL8, TNFα, soluble...
Observational studies have suggested a protective role for eosinophils in colorectal cancer (CRC) development and implicated neutrophils, but the causal relationships remain unclear. Here, we aimed to estimate effect of circulating white blood cell (WBC) counts (N = ~550 000) basophils, eosinophils, monocytes, lymphocytes neutrophils on CRC risk 52 775 cases 45 940 controls) using Mendelian randomisation (MR). For comparison, also examined this relationship individual-level data from UK...
Gene fusions are found as cancer drivers in diverse adult and pediatric cancers. Accurate detection of fusion transcripts is essential clinical diagnostics prognostics for guiding therapeutic development. Most currently available methods transcript compatible with Illumina RNA-seq involving highly accurate short-read sequences. Recent advances long-read isoform sequencing enable the at unprecedented resolution bulk single-cell samples. Here, we developed a new computational tool,...
The objective of this study was to examine the effect breast density and age on screening mammograms with false-positive findings.The sample taken from Washington State Mammography Tumor Registry, which links data participating radiologists Puget Sound Cancer Surveillance System Registry. Participants (n = 73,247) were women 35 years old older who underwent mammography for an assessment a four-category rating coded. A total 46,340 sampled avoid interpreter bias. In mammograms, only no...