A5063443876- Epigenetics and DNA Methylation
- Diet and metabolism studies
- Health disparities and outcomes
- Birth, Development, and Health
- Dementia and Cognitive Impairment Research
- Obesity, Physical Activity, Diet
- Health, Environment, Cognitive Aging
- Cancer-related gene regulation
- Aging, Health, and Disability
- Nutritional Studies and Diet
- Health and Lifestyle Studies
- Liver Disease Diagnosis and Treatment
- Coffee research and impacts
- Intergenerational Family Dynamics and Caregiving
- Adipose Tissue and Metabolism
- RNA modifications and cancer
- Physical Activity and Health
- Alcohol Consumption and Health Effects
- COVID-19 Pandemic Impacts
- Cancer, Lipids, and Metabolism
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Body Composition Measurement Techniques
- Advanced Neuroimaging Techniques and Applications
- Frailty in Older Adults
- Cardiovascular Disease and Adiposity
Erasmus MC
2018-2024
Adolfo Ibáñez University
2022-2024
University of Concepción
2018-2024
Radboud University Nijmegen
2024
Radboud University Medical Center
2024
University Medical Center
2024
Erasmus University Rotterdam
2018-2024
Abstract To date, non-pharmacological interventions (NPI) have been the mainstay for controlling coronavirus disease-2019 (COVID-19) pandemic. While NPIs are effective in preventing health systems overload, these long-term measures likely to significant adverse economic consequences. Therefore, many countries currently considering lift NPIs—increasing likelihood of disease resurgence. In this regard, dynamic NPIs, with intervals relaxed social distancing, may provide a more suitable...
Differences in health status by socioeconomic position (SEP) tend to be more evident at older ages, suggesting the involvement of a biological mechanism responsive accumulation deleterious exposures across lifespan. DNA methylation (DNAm) has been proposed as biomarker aging that conserves memory endogenous and exogenous stress during life.We examined association education level, an indicator SEP, lifestyle-related variables with four biomarkers age-dependent DNAm dysregulation: total number...
Abstract Latin American populations may present patterns of sociodemographic, ethnic and cultural diversity that can defy current universal models healthy aging. The potential combination risk factors influence aging across in Caribbean (LAC) countries is unknown. Compared to other regions where classical such as age sex drive aging, higher disparity-related between-country variability could LAC countries. We investigated the combined impact social determinants health (SDH), lifestyle...
Abstract BACKGROUND Education influences brain health and dementia. However, its impact across regions, specifically Latin America (LA) the United States (US), is unknown. METHODS A total of 1412 participants comprising controls, patients with Alzheimer's disease (AD), frontotemporal lobar degeneration (FTLD) from LA US were included. We studied association education volume functional connectivity while controlling for imaging quality variability, age, sex, intracranial (TIV), recording...
DNA methylation patterns associated with habitual diet have not been well studied. Diet quality was characterized using a Mediterranean-style score and the Alternative Healthy Eating Index score. We conducted ethnicity-specific trans-ethnic epigenome-wide association analyses for leukocyte-derived at over 400 000 CpGs (cytosine-guanine dinucleotides) in 5 population-based cohorts including 6662 European ancestry, 2702 African 360 Hispanic ancestry participants. For diet-associated identified...
OBJECTIVE To investigate the role of epigenetics in statins’ diabetogenic effect comparing DNA methylation (DNAm) between statin users and nonusers an epigenome-wide association study blood. RESEARCH DESIGN AND METHODS Five cohort studies’ participants (n = 8,270) were classified as when they on therapy at time DNAm assessment with Illumina 450K or EPIC array noncurrent otherwise. Associations various outcomes like incident type 2 diabetes, plasma glucose, insulin, insulin resistance (HOMA...
Coffee is among the most consumed beverages worldwide. consumption has been associated with lower risk of type 2 diabetes mellitus (T2D), but underlying mechanisms are not well understood. We aimed to study role classic and novel-T2D biomarkers anti- or pro-inflammatory activity in association between habitual coffee intake T2D risk. Furthermore, we studied differences by types smoking status this association.Using two large population-based cohorts, UK-Biobank (UKB; n = 145,368) Rotterdam...
Aims There are several epidemiological studies on the association between statins and incident diabetes, but most of them lack details. In this study, we aimed to investigate statin use with glycaemic traits type 2 diabetes. Methods Using prospective population‐based Rotterdam Study, included 9535 individuals free from diabetes at baseline (>45 years) during study period 1997 2012. Linear regression analysis was applied examine cross‐sectional associations including fasting blood serum...
Evidence suggests neutral or moderately beneficial effects of dairy intake on type 2 diabetes mellitus risk. Nevertheless, evidence associations with early phases remains inconsistent. We aimed to examine between dairy-type prediabetes risk and longitudinal insulin resistance. The analytic sample consisted 6770 participants (aged 62 ± 4 years, 59% female) free (pre-)diabetes at baseline from the prospective population-based Rotterdam Study. Dairy was measured using food frequency...
Whether beverage quality affects changes in glycaemic traits and type 2 diabetes (T2D) risk is unknown. We examined associations of a previously developed Healthy Beverage Index (HBI) with insulin resistance, prediabetes T2D.We included 6769 participants (59% female, 62.0 ± 7.8 years) from the Rotterdam Study cohort free at baseline. Diet was assessed using food-frequency questionnaires The HBI 10 components (energy beverages, meeting fluid requirements, water, coffee tea, low-fat milk, diet...
Objectives To investigate associations of the ‘weekend warrior’ physical activity pattern with mild dementia. Methods Participants in Mexico City Prospective Study were surveyed from 1998 to 2004 and re-surveyed 2015 2019. asked about leisure time at baseline. Those who exercised up once or twice per week termed warriors’ those more often ‘regularly active’. A Mini Mental State Examination (MMSE) was used assess dementia re-survey. Cox models adjusted for age, sex, education, income, blood...
Antecedentes: Aunque se ha documentado la eficacia de las intervenciones vía mobile health (mHealth) para aumentar el ejercicio físico, existe evidencia limitada sobre motivación, barreras y los beneficios asociados a práctica físico en este tipo mHealth. Objetivo: Examinar diferencias entre mHealth presencial. Método: Estudio preexperimental 37 adultos (96,5% mujeres, 43 ±10,5 años) del Biobío, Chile, quienes participaron una intervención Se utilizó Cuestionario Regulación Conducta...
To model disease progression, healthcare demand and case fatality rate attributed to COVID-19 pandemic that may occur in Chile 1-month time, by simulating different scenarios according diverse mitigation measures hypothetically implemented. Furthermore, we aimed estimate the same outcomes assuming 70% of population will be infected SARS-CoV-2, with no time limit assumption.We based on number confirmed cases up April 14th 2020 (8 273 94 deaths). For simulated assumed basic reproduction...
Epigenome-wide association studies have revealed multiple DNA methylation sites (CpGs) associated with alcohol consumption, an important lifestyle risk factor for cardiovascular diseases. We generated consumption epigenetic score (ERS) based on previously reported 144 alcohol-associated CpGs and examined the of ERS systolic blood pressure (SBP), diastolic (DBP), hypertension (HTN) in 3,898 Framingham Heart Study (FHS) participants. found intake meta-analysis 0.09 units higher per drink...
Epigenome-wide association studies have revealed multiple DNA methylation sites (CpGs) associated with alcohol consumption, an important lifestyle risk factor for cardiovascular diseases.
ABSTRACT Importance There is limited population-based evidence on the prevalence of cognitive impairment in Mexico, a country with rapidly aging population and where key risk factors, such as diabetes obesity, are common. Objective To describe distribution sample adults from Mexico City. Design, Setting, Participants This cross-sectional study included participants City Prospective Study which 50,000 men 100,000 women aged ≥35 years two districts 1998-2004. In 2015-2019 about 10,000...
Background: The vegan diet (VEGD) has gained popularity in recent years for ecological and ethical reasons, as well its health benefits. In addition to the type of diet, resistance training program (RTP) plays a fundamental role one main natural anabolic stimuli increase musculoskeletal mass reduce fat mass. Methods: study was 16-week non-randomized controlled clinical trial consisting three RTP sessions per week. sample included 70 Chilean individuals, aged between 18 59 years, who had been...