A5087561429- Lipoproteins and Cardiovascular Health
- Bariatric Surgery and Outcomes
- Cardiovascular Disease and Adiposity
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cancer, Lipids, and Metabolism
- Diet and metabolism studies
- Lysosomal Storage Disorders Research
- Glaucoma and retinal disorders
- Pancreatitis Pathology and Treatment
- Ocular Surface and Contact Lens
- Atherosclerosis and Cardiovascular Diseases
- Pituitary Gland Disorders and Treatments
- Adipokines, Inflammation, and Metabolic Diseases
- Diabetes and associated disorders
- Corneal surgery and disorders
- Adrenal Hormones and Disorders
- Body Contouring and Surgery
- COVID-19 Clinical Research Studies
- Lipid metabolism and disorders
- Sphingolipid Metabolism and Signaling
- Hormonal and reproductive studies
- Pharmacology and Obesity Treatment
- Pain Mechanisms and Treatments
- Paraoxonase enzyme and polymorphisms
- Neuroendocrine Tumor Research Advances
The Christie NHS Foundation Trust
2021-2025
Singapore General Hospital
2015-2024
Austin Health
2024
Manchester University NHS Foundation Trust
2016-2022
University of Manchester
2017-2022
The Christie Hospital
2021-2022
St Mary's Hospital
2017-2021
Manchester Royal Infirmary
2019-2021
Manchester University
2019
St George's, University of London
2001-2018
There are limited data on the impact of bariatric surgery microvascular complications type 2 diabetes (T2D), particularly diabetic neuropathy. We assessed (especially neuropathy) in obese patients with T2D before and 12 months after surgery.This was a prospective observational cohort study. Measurements neuropathy symptom profile (NSP), disability score (NDS), vibration (VPT), cold (CPT) warm (WPT) perception thresholds, nerve conduction studies (NCS) corneal confocal microscopy (CCM) to...
Hypercholesterolaemia is amongst the most common conditions encountered in medical profession.It remains one of key modifiable cardiovascular risk factors and there have been recent advances stratification methods treatment options available.In this review, we provide a background into hypercholesterolaemia for non-specialists consider merits different assessment tools available.We also detailed considerations as to: i) when to start treatment, ii) what targets aim iii) role low density...
Obesity is a major modifiable risk factor for cardiovascular disease. Bariatric surgery considered to be the most effective treatment option weight reduction in obese patients with and without type 2 diabetes (T2DM).To evaluate changes lipoproteins, insulin resistance, mediators of systemic vascular inflammation, endothelial dysfunction following Roux-en-Y bariatric diabetes.Lipoproteins, were measured 37 (n = 17) 20) T2DM, before 6 12 months after surgery. Two way between subject ANOVA was...
Journal Article Accepted manuscript Clinical Impact of Variations in Laboratory Measurements Growth Hormone and Insulin-Like Factor 1 on the Classification Acromegaly Disease Activity Status United Kingdom Get access Paul Benjamin Loughrey, Loughrey Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, UKRegional Endocrinology Diabetes, Belfast Health Social Care Trust, UK https://orcid.org/0000-0002-5491-6730 Search other works by this author on: Oxford Academic Google...
Chronic idiopathic intestinal pseudo-obstruction is a syndrome in which symptoms of obstruction are present the absence mechanical obstruction. Lack normal pacemaker activity, usually generated by interstitial cells Cajal (ICC), could account for apparent ICC normally located around and between myenteric plexus ganglia within muscle also deep muscular small bowel submuscular large intestine, just circular muscle. can be demonstrated immunohistochemically with CD117 (c-kit) as well CD34,...
Abstract Accurately quantifying the progression of diabetic peripheral neuropathy is key to identify individuals who will progress foot ulceration and power clinical intervention trials. We have undertaken detailed phenotyping assess longitudinal utility different measures in patients with diabetes. Nineteen diabetes (age 52.5 ± 14.7 years, duration 26.0 13.8 years) 19 healthy controls underwent assessment symptoms signs neuropathy, quantitative sensory testing, autonomic nerve function,...
Purpose: Obesity is associated with peripheral neuropathy, which bariatric surgery may ameliorate. The aim of this study was to assess whether corneal confocal microscopy can show a change in nerve morphology and keratocyte density subjects severe obesity after surgery. Methods: Twenty obese patients diabetes (n = 13) without 7) underwent assessment hemoglobin A1c (HbA1c), lipids, IL-6, highly sensitive C-reactive protein (hsCRP), before 12 months Corneal fiber (CNFD), branch (CNBD), length...
Abstract Obesity and associated dyslipidemia may contribute to increased cardiovascular disease. has also been with neuropathy. We have investigated presence of peripheral nerve damage in patients severe obesity without type 2 diabetes the status metabolic syndrome lipoprotein abnormalities. 47participants 30 age-matched healthy controls underwent detailed phenotyping neuropathy an assessment lipoproteins HDL-functionality. Participants had a higher symptom profile, lower sural peroneal...
Emerging evidence suggests an association between impaired high-density lipoprotein (HDL) functionality and cardiovascular disease (CVD). HDL is essential for reverse cholesterol transport (RCT) reduces inflammation oxidative stress principally via paraoxonase-1 (PON1). RCT depends on HDL's capacity to accept (cholesterol efflux [CEC]) active through ATP-binding cassette (ABC) A1, G1, scavenger receptor-B1 (SR-B1). We have studied the impact of Roux-en-Y gastric bypass (RYGB) in morbidly...
Reaven originally described the clustering of insulin resistance/hyperinsulinaemia, obesity (particularly visceral), altered cytokine levels, glucose intolerance, hypertriglyceridaemia and low high-density lipoprotein cholesterol. Subsequently, a potentially highly atherogenic small, dense low-density was also reported. We have studied effect bariatric surgery on this other risk factors for atherosclerosis.Forty patients (20 with type 2 diabetes mellitus) undergoing were before 1 year after...
Context Multiple factors contribute to sexual dysfunction in men with obesity. Sex hormone levels are commonly abnormal obesity and this abnormality is often the focus of management clinical practice. The role small fibre neuropathy obesity-related not well established. Objective We aimed investigate relationship between function, sex nerve morphology severe Materials methods A prospective study 29 was undertaken. Sexual function assessed using European Male Ageing Study Function...
Roux-en-Y gastric bypass (RYGB) is one of the most commonly performed weight-loss procedures, but how severe obesity and RYGB affect circulating HDL-associated microRNAs (miRNAs) remains unclear. Here, we aim to investigate miRNAs are regulated in weight loss after surgery affects HDL-miRNAs. Plasma HDLs were isolated from patients with (n = 53) before 6 12 months by immunoprecipitation using goat anti-human apoA-I microbeads. also 18 healthy participants. extracted HDL levels miR-24,...
<h3>ABSTRACT</h3> Ambulatory emergency care forms a fundamental part of the strategy trying to ensure safe and sustainable acute services. Immune checkpoint inhibitor(ICI)-mediated hypophysitis is an important life-threatening complication therapy. Patients presenting with clinical features findings consistent ICI-mediated were considered in current study. In absence severe (sodium <125 mmol/L, hypotension, reduced consciousness, hypoglycaemia and/or visual field defect), patients...