A5014919097- Bariatric Surgery and Outcomes
- Diet and metabolism studies
- Lipoproteins and Cardiovascular Health
- Cardiovascular Disease and Adiposity
- Lipid metabolism and disorders
- Ocular Surface and Contact Lens
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Glaucoma and retinal disorders
- Corneal surgery and disorders
- COVID-19 Clinical Research Studies
- Pharmaceutical Economics and Policy
- Body Contouring and Surgery
- Liver Disease Diagnosis and Treatment
- Lysosomal Storage Disorders Research
- Pancreatitis Pathology and Treatment
- Pain Mechanisms and Treatments
- Vitamin C and Antioxidants Research
- Nutritional Studies and Diet
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Retinal Diseases and Treatments
- Botulinum Toxin and Related Neurological Disorders
- Atherosclerosis and Cardiovascular Diseases
- Autoimmune and Inflammatory Disorders Research
- Adipose Tissue and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
University of Manchester
2015-2024
Manchester Academic Health Science Centre
2021-2024
Manchester University NHS Foundation Trust
2019-2023
NIHR Wellcome Trust Southampton Clinical Research Facility
2021-2022
Centre of Excellence in Molecular Biology
2022
University of the Punjab
2022
Cardiovascular Research Center
2021
Salford Royal NHS Foundation Trust
2020-2021
Manchester Royal Infirmary
2021
University Foundation
2021
There are limited data on the impact of bariatric surgery microvascular complications type 2 diabetes (T2D), particularly diabetic neuropathy. We assessed (especially neuropathy) in obese patients with T2D before and 12 months after surgery.This was a prospective observational cohort study. Measurements neuropathy symptom profile (NSP), disability score (NDS), vibration (VPT), cold (CPT) warm (WPT) perception thresholds, nerve conduction studies (NCS) corneal confocal microscopy (CCM) to...
Diabetes Mellitus is the most common endocrine disorder and metformin commonly prescribed oral hypoglycemic agent. Metformin well known to cause viamin B12 deficiency due effect on calcium-dependent membrane action in terminal ileum leading malabsorption of vitamin B12. The purpose this study determine prevalence associations Vitamin patients type 2 diabetes mellitus treated with metformin.This case control was carried out department medicine, Combined Military Hospital, Kharian from 1(st)...
Purpose: Obesity is associated with peripheral neuropathy, which bariatric surgery may ameliorate. The aim of this study was to assess whether corneal confocal microscopy can show a change in nerve morphology and keratocyte density subjects severe obesity after surgery. Methods: Twenty obese patients diabetes (n = 13) without 7) underwent assessment hemoglobin A1c (HbA1c), lipids, IL-6, highly sensitive C-reactive protein (hsCRP), before 12 months Corneal fiber (CNFD), branch (CNBD), length...
Emerging evidence suggests an association between impaired high-density lipoprotein (HDL) functionality and cardiovascular disease (CVD). HDL is essential for reverse cholesterol transport (RCT) reduces inflammation oxidative stress principally via paraoxonase-1 (PON1). RCT depends on HDL's capacity to accept (cholesterol efflux [CEC]) active through ATP-binding cassette (ABC) A1, G1, scavenger receptor-B1 (SR-B1). We have studied the impact of Roux-en-Y gastric bypass (RYGB) in morbidly...
Abstract Purpose Bariatric surgery is associated with deficiencies of vitamins and minerals, patients are routinely advised supplements postoperatively. We studied prevalence vitamin B 12 , folate iron anaemia before after bariatric over 4 years follow-up. Materials Methods performed a retrospective cohort analysis 353 people obesity, including 257 (72.8%) women, who underwent gastric bypass (252, 71.4%) or sleeve gastrectomy (101, 28.6%) at our National Health Service centre in Northwest...
Roux-en-Y gastric bypass (RYGB) is one of the most commonly performed weight-loss procedures, but how severe obesity and RYGB affect circulating HDL-associated microRNAs (miRNAs) remains unclear. Here, we aim to investigate miRNAs are regulated in weight loss after surgery affects HDL-miRNAs. Plasma HDLs were isolated from patients with (n = 53) before 6 12 months by immunoprecipitation using goat anti-human apoA-I microbeads. also 18 healthy participants. extracted HDL levels miR-24,...
Abstract Background Enzyme replacement therapy (ERT) with olipudase alfa, a recombinant human acid sphingomyelinase (rhASM), is being developed to treat patients ASM deficiency (ASMD), commonly known as Niemann–Pick disease (NPD) types A or B. This study assessed the effect of ERT on lipid parameters and inflammatory markers. Methods Serum plasma samples from five adults NPD type B (NPD-B) who received alfa for 26 weeks were analysed. We also collected fasting blood fifteen age- sex-matched...
Severe obesity is a disease associated with multiple adverse effects on health. Metabolic bariatric surgery (MBS) can have significant body systems and was shown to improve inflammatory markers in previous short-term follow-up studies. We evaluated associations between changes (CRP, IL6 TNFα) circulating proteins after MBS.Sequential window acquisition of all theoretical mass spectra (SWATH-MS) proteomics performed plasma samples taken at baseline (pre-surgery) 6 12 months MBS, concurrent...
Bariatric surgery (BS) results in metabolic pathway recalibration. We have identified potential biomarkers plasma of people achieving type 2 diabetes mellitus (T2DM) remission after BS. Longitudinal analysis was performed on from 10 individuals following Roux-en-Y gastric bypass (n = 7) or sleeve gastrectomy 3). Sequential window acquisition all theoretical fragment ion spectra mass spectrometry (SWATH-MS) done samples taken at 4 months before (baseline) and 6 12 Four hundred sixty-seven...