A5061070284- Adipose Tissue and Metabolism
- Diet and metabolism studies
- Fatty Acid Research and Health
- Muscle metabolism and nutrition
- Nutrition and Health in Aging
- Muscle Physiology and Disorders
- Mitochondrial Function and Pathology
- Adipokines, Inflammation, and Metabolic Diseases
- Exercise and Physiological Responses
- Liver Disease Diagnosis and Treatment
- Lipid metabolism and biosynthesis
- Peroxisome Proliferator-Activated Receptors
- Diet, Metabolism, and Disease
- Metabolism and Genetic Disorders
- Metabolomics and Mass Spectrometry Studies
- Body Composition Measurement Techniques
- Gut microbiota and health
- Nutritional Studies and Diet
- Metabolism, Diabetes, and Cancer
- Rheumatoid Arthritis Research and Therapies
- Lipoproteins and Cardiovascular Health
- Probiotics and Fermented Foods
- Antioxidant Activity and Oxidative Stress
- Pharmacology and Obesity Treatment
- Cholesterol and Lipid Metabolism
Unité de Nutrition Humaine
2015-2024
Université Clermont Auvergne
2006-2024
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2015-2024
Centre de Recherche en Nutrition Humaine d'Auvergne
2015-2024
Centre de Recherche en Nutrition Humaine Rhône-Alpes
2018-2023
Centre Nantais de Sociologie
2023
Institut National Polytechnique de Toulouse
2023
Clermont Université
2015-2022
Santa Casa de Votuporanga
2017
Servier (France)
2011-2013
Importance Sarcopenia and obesity are 2 global concerns associated with adverse health outcomes in older people. Evidence on the population-based prevalence of combination sarcopenia (sarcopenic [SO]) its association mortality still limited. Objective To investigate SO their all-cause mortality. Design, Setting, Participants This large-scale, cohort study assessed participants from Rotterdam Study March 1, 2009, to June 2014. Associations were studied using Kaplan-Meier curves, Cox...
OBJECTIVE We investigated the regulation of adipose tissue gene expression during different phases a dietary weight loss program and its relation with insulin sensitivity. RESEARCH DESIGN AND METHODS Twenty-two obese women followed intervention composed an energy restriction phase 4-week very-low-calorie diet stabilization period 2-month low-calorie by 3–4 months maintenance diet. At each time point, euglycemic-hyperinsulinemic clamp subcutaneous biopsies were performed. Adipose profiling...
SummarySarcopenic obesity (SO) is defined as the combination of excess fat mass (obesity) and low skeletal muscle function (sarcopenia). The identification classification factors related to SO would favor better prevention diagnosis. present article aimed (i) define a list with based on literature analysis, (ii) identify clinical conditions linked development from search (iii) evaluate their relevance potential research gaps by consulting an expert panel.From 4746 articles screened, 240 were...
Abstract TRUEFAD (TRUE Fiber Atrophy Distinction) is a bioimagery user-friendly tool developed to allow consistent and automatic measurement of myotube diameter in vitro, muscle fiber size type using rodents human biopsies. This package was set up standardize dynamize research via easy-to-obtain images run on an open-source plugin for FIJI. We showed here both the robustness performance our pipelines correctly segment cells fibers. evaluated pipeline real experiment image sets reliability...
Context: Retinol-binding protein 4 (RBP4) may play a role in the development of insulin resistance. Objective: We investigated whether RBP4 adipose tissue mRNA expression and plasma level are related to sensitivity during diet-induced weight loss. Design, Setting, Patients, Intervention: Obese women followed dietary intervention composed 4-wk very low-calorie diet (VLCD), 2-month diet, 3–4 months maintenance (WM) phase. Main Outcome Measures: Clinical investigation was performed before at...
The transcription factor 7-like 2 (TCF7L2) rs7903146 T allele was previously associated with type diabetes (T2D) and decreased BMI whereas haplotypes carrying the C rs10885406 A alleles (HapA) were increased BMI. functional relevance of TCF7L2 polymorphisms their effects on T2D obesity remained to be further investigated. In white European populations, we found that more in 3,547 non-obese individuals (odds ratio (OR) = 1.88 (1.69-2.10)) than 1,110 class III obese subjects (OR 1.24...
Hypoenergetic diets are used to reduce body fat mass and metabolic risk factors in obese subjects. The molecular changes adipose tissue associated with weight loss specifically related the dietary composition poorly understood.We investigated gene expression from human women according energy deficit carbohydrate content of diet.Obese subjects recruited among eight European clinical centers were followed up 10 wk either a low-fat (high carbohydrate) or moderate-fat (low hypoenergetic diet.Two...
The impact of alpha linolenic acid (ALA), EPA, and DHA on obesity metabolic complications was studied in mice fed a high-fat, high-sucrose (HF) diet. HF diets were supplemented with ALA, or (1% w/w) given to C57BL/6J for 16 weeks Ob/Ob 6 weeks. In mice, EPA reduced plasma cholesterol (−20%), limited fat mass accumulation (−23%) adipose cell hypertrophy (−50%), leptin concentration (−60%) compared HF-fed mice. Furthermore, exhibited higher insulin sensitivity (+24%) glucose tolerance (+20%)...
Abstract Background Muscle wasting prevails in numerous diseases (e.g. diabetes, cardiovascular and kidney diseases, COPD,…) increases healthcare costs. A major clinical issue is to devise new strategies preventing muscle wasting. We hypothesized that 8‐week docosahexaenoic acid (DHA) supplementation prior fasting may preserve mass vivo . Methods Six‐week‐old C57BL/6 mice were fed a DHA‐enriched or control diet for 8 weeks then fasted 48 h. Results Feeding elevated glycogen contents, reduced...
Body composition (BC) is an emerging important factor for the characterization of metabolic status. The assessment BC has been studied in various populations and diseases such as obesity, diabetes, endocrine well physiological paraphysiological conditions growth aging processes, physical training. A gold standard technique human at molecular level represented by dual-energy X-ray absorptiometry (DXA), which able to precisely assess measure body mass (and areal bone mineral density-aBMD) on a...
Dietary fat subtypes may play an important role in the regulation of muscle mass and function during ageing. The aim present study was to determine impact isocaloric macronutrient substitutions, including different subtypes, on sarcopenia risk older men women, while accounting for physical activity (PA) metabolic risk. A total 986 participants, aged 65–79 years, completed a 7-day food record wore accelerometer week. continuous sex-specific score (SRS), skeletal assessed by dual-energy X-ray...
The phenotype of sarcopenic obesity is frequently associated with impaired muscle strength and performance. Ectopic lipid deposition may interfere anabolic response especially during aging. Evidence scarce concerning the potential interplay among aging nutrient imbalance on skeletal functionality. objective present study was to investigate impact protein intake in context an obesogenic diet functional properties intramuscular infiltration. Two groups forty-two adult thirty-seven old male...
Key points Some studies suggest that neuregulin 1 (NRG1) could be involved in the regulation of skeletal muscle energy metabolism rodents. Here we assessed whether unbalanced diet is associated with alterations NRG1 signalling pathway and exercise might restore obese rats. We show diet‐induced obesity does not impair rat muscle. also report endurance training a well‐balanced activate rats, possibly via new mechanism mediated by protease ADAM17. These results some beneficial effects physical...