A5025428879- Retinal Diseases and Treatments
- Retinal Imaging and Analysis
- Glaucoma and retinal disorders
- Retinal and Optic Conditions
- Ocular Diseases and Behçet’s Syndrome
- Retinal and Macular Surgery
- Optical Coherence Tomography Applications
- Systemic Lupus Erythematosus Research
- Retinal Development and Disorders
- Ocular Infections and Treatments
- High Altitude and Hypoxia
- Intraocular Surgery and Lenses
- Drug-Induced Ocular Toxicity
- Maternal and Perinatal Health Interventions
- Child and Adolescent Health
- Cerebral Venous Sinus Thrombosis
- Vascular Malformations Diagnosis and Treatment
- Breastfeeding Practices and Influences
- Blood groups and transfusion
- Congenital limb and hand anomalies
- Medicine and Dermatology Studies History
- HIV/AIDS Research and Interventions
- Parathyroid Disorders and Treatments
- Gestational Diabetes Research and Management
- Malaria Research and Control
University of Milan
2016-2025
University Hospital of Zurich
2024-2025
University of Zurich
2024-2025
Luigi Sacco Hospital
2015-2024
Novartis (Switzerland)
2022
Howard Hughes Medical Institute
2022
Doheny Eye Institute
2020
University Hospitals Coventry and Warwickshire NHS Trust
2015-2019
University of Udine
2007-2018
Bayer (Germany)
2017
The introduction of wide field optical coherence tomography (WF-OCT) has provided newer insights in the imaging peripheral choroid. We evaluated choroidal thickness (CT) and large vessel (LCVT) 20 eyes horizontal vertical meridians using WF-OCT. A high-definition line scan through fovea both meridian was captured primary extremes gaze to obtain scans up mid-equator. CT LCVT measurements were done across predefined points macular area all quadrants. calculated after identifying a near...
Importance Randomized clinical trials are conducted to establish both drug safety and efficacy. However, evidence of adverse events associated with these drugs in the practice setting can be value at generating hypotheses regarding less common issues, even if causality cannot determined. Objective To present analyze cases intraocular inflammation faricimab therapy patients referred a single European institution. Design, Setting, Participants This was review starting April 2024 an...
Purpose: To correlate changes in choroidal thickness and vascularity index with disease activity patients neovascular age-related macular degeneration (nAMD). Methods: Eyes diagnosed AMD that had two sequential visits within 12 months no neovascularization (CNV) or inactive CNV at the first visit were included. Those active follow-up enrolled as cases. did not developed a still second controls. Disease was based on optical coherence tomography (OCT) fluorescein angiography findings....
To detect choriocapillaris changes by enhanced depth imaging optical coherence tomography (EDI-OCT) in areas of hypoperfusion visualized on indocyanine green angiography.Combined angiography and EDI-OCT from patients diagnosed with inflammatory were retrospectively analyzed. The EDI-OCTs compared to suggestive both active stage (AS) inactive the disease. was graded two independent observers for pattern (normal/altered) reflectivity (hyper/hypo/isoreflective) changes. Manual measurements...
To compare indocyanine green angiography and four different optical coherence tomography (OCTA) devices to test their reproducibility in the evaluation of choroidal neovascularization (CNV).This study was an observational case series Type 1 2 CNV presenting at Eye Clinic, Department Biomedical Clinical Sciences, Luigi Sacco Hospital, University Milan, imaged with OCTA devices: prototype PlexElite (Carl Zeiss Meditec), Spectralis (Spectralis; Heidelberg Engineering, Heidelberg, Germany),...
Background To compare fluorescein angiography (FA) and five different optical coherence tomography (OCTA) devices to test their reproducibility in the evaluation of retinal microaneurysms (MAs) secondary diabetic retinopathy (DR). Methods On same day, patients with DR were imaged FA OCTA devices: prototype Spectralis OCTA, PlexElite, RTVue XR Avanti, AngioPlex DRI OCT Triton. For all devices, a 3×3 volume scan pattern was performed. MAs evaluated for superficial capillary plexus (SCP) deep...
Purpose: To describe vitreal, retinal, and choroidal features of eyes affected by Endogenous candida endophthalmitis (ECE) analyzed spectral domain optical coherence tomography (SD-OCT) to evaluate their clinical impact. Methods: Medical records SD-OCT images from diagnosed with ECE at four retina uveitis tertiary referral centers were retrospectively evaluated. Spectral the structural changes occurring in vitreous, retina, choroid areas involved ECE. Baseline final best-corrected visual...
To compare swept source OCTA device, with and without the extended field imaging (EFI) technique, to standard fluorescein angiography (FA) in clinical practice.Consecutive patients vascular disorder underwent FA 55-degree lens (Spectralis Heidelberg Engineering, Heidelberg, Germany) prototype PlexElite (Carl Zeiss Meditec, Dublin, CA) using a 12 mm x volume scan pattern centered on fovea of + 20.00-diopter designed specifically by Zeiss. The methods were compared for visible view, extension...
To report the incidence and risk factors for fibrosis at 10 years in a large cohort of persons with neovascular age-related macular degeneration (nAMD).Retrospective, multicenter, study.We included 225 naive nAMD eyes that underwent intravitreal anti−vascular endothelial growth factor treatment over follow-up two Italian referral centers. Demographic clinical data were reviewed baseline on an annual basis. Onset was defined by clinically assessing photographs, fundus descriptions, or...
Purpose: To describe the imaging characteristics and topographic expansion of retinal pigment epithelium (RPE) outer atrophy in extensive macular with pseudodrusen-like appearance. Methods: Three-year, prospective, observational study. Nine patients appearance (17 eyes; 6 women) no other ocular conditions were annually examined; one eye was excluded because neovascularization. Best-corrected visual acuity measurement, fundus photographs, blue-light autofluorescence, optical coherence...
Background/Aims To investigate the presence of short-wave fluorophores within regions age-related macular degeneration (AMD)-associated atrophy (MA) area. Methods This is a prospective, observational, cross-sectional case series. 25 eyes (18 patients) with late AMD and clinically identified MA were enrolled. Eyes imaged using confocal light-emitting diode blue-light fundus autofluorescence (FAF) device (EIDON, CenterVue, Padua, Italy) 450 nm excitation wavelength capability for ‘colour’ FAF...
Background/aims To systematically compare the intermodality and inter-reader agreement for two blue-light confocal fundus autofluorescence (FAF) systems. Methods Thirty eyes (21 patients) with a diagnosis of geographic atrophy (GA) were enrolled. Eyes imaged using FAF devices: (1) Spectralis device 488 nm excitation wavelength (488-FAF); (2) EIDON 450 capability ‘colour’ imaging including both individual red green components emission spectrum. Furthermore, third modality (450-RF image)...
To report visual outcomes and rate of retinal pigment epithelium (RPE) atrophy progression in patients with extensive macular pseudodrusen-like appearance (EMAP).Retrospective, observational study.Patients EMAP symptom onset before 55 years age, at least 12 months follow-up using Spectralis blue-light fundus autofluorescence (BAF) OCT no other ocular or systemic conditions.Best-corrected acuity (BCVA), BAF, images were reviewed baseline each annual visit until the last available follow-up....
Purpose: This study aims to investigate the potential in vivo relationship between macular pigment (MP) and retinal layers thickness healthy subjects dry, non-advanced age-related degeneration (AMD). Methods: An observational, cross-sectional was conducted. Healthy >40 years patients with early or intermediate AMD were recruited. Structural OCT optical volume (MPOV) collected for each subject. Retinal parameters calculated based on standard treatment diabetic retinopathy (ETDRS) map....