To improve the quality of optical coherence tomography (OCT) images optic nerve head (ONH).Two algorithms were developed, one to compensate for light attenuation and other enhance contrast in OCT images. The former was borrowed from developments ultrasound imaging proven suitable with either time- or spectral-domain OCT. latter based on direct application pixel intensity exponentiation. performances these two tested four adult ONHs.Application compensation algorithm significantly reduced...

Given that the neural and connective tissues of optic nerve head (ONH) exhibit complex morphological changes with development progression glaucoma, their simultaneous isolation from optical coherence tomography (OCT) images may be great interest for clinical diagnosis management this pathology. A deep learning algorithm (custom U-NET) was designed trained to segment 6 ONH tissue layers by capturing both local (tissue texture) contextual information (spatial arrangement tissues). The overall...

We improved the visibility of lamina cribrosa (LC), including its posterior boundary, in optical coherence tomography (OCT) images human optic nerve head (ONH).An adaptive compensation algorithm was developed to overcome a limitation our standard algorithm, that is overamplification noise at high depth. Such currently hampers ability distinguish LC boundary. In compensation, operations are performed until an energy threshold reached, which stage process stopped limit deeper portion OCT...

To develop a deep learning approach to digitally stain optical coherence tomography (OCT) images of the optic nerve head (ONH).A horizontal B-scan was acquired through center ONH using OCT (Spectralis) for one eye each 100 subjects (40 healthy and 60 glaucoma). All were enhanced adaptive compensation. A custom network then designed trained with compensated (i.e., highlight) six tissue layers ONH. The accuracy our algorithm assessed (against manual segmentations) dice coefficient,...

To compare the visibility of lamina cribrosa (LC) in optic disc images acquired from 60 glaucoma and control subjects using three optical coherence tomography (OCT) devices, with without enhanced depth imaging (EDI) adaptive compensation (AC).A horizontal B-scan was through center two spectral-domain (Spectralis Cirrus; EDI) a swept-source (DRI) OCT. Adaptive applied post acquisition to improve image quality. assess LC visibility, four masked observers graded 1200 randomized sequence. The...

Purpose: To compare the capability of lamina cribrosa depth (LCD) and (LC) curvature in discriminating between eyes with primary open-angle glaucoma (POAG) healthy eyes. Methods: Seventy-seven 77 patients POAG subjects who were matched for age, sex, axial length included. The LCD index (LCCI) measured B-scan images obtained using swept-source optical coherence tomography at seven locations spaced equidistantly across vertical optic disc diameter. mean values measurements made points LC...

Abstract Purpose To determine the distribution of choroidal thickness (CT) and ocular factors associated with CT in high myopic eyes comparison emmetropic young healthy adults. Methods A case–control study 648 young, male subjects, including 520 myopes 128 emmetropes. Choroidal imaging was performed using enhanced depth spectral domain optical coherence tomography. Images were postprocessed adaptive compensation for quality enhancement. measured at nine locations, subfovea 1.5 3 mm nasal,...

Measurement of optic nerve head (ONH) deformations could be useful in the clinical management glaucoma. Here, we propose a novel three-dimensional tissue-tracking algorithm designed to used vivo. We carry out preliminary verification by testing its accuracy and robustness. An based on digital volume correlation was developed extract ONH tissue displacements from two optical coherence tomography (OCT) volumes (undeformed deformed). The tested applying artificial baseline OCT scan while...

Purpose.: This study explores variation in the axial location of Bruch's membrane opening (BMO) to determine if this reference plane varies with age and race. Methods.: There were 168 spectral-domain optical coherence tomography (SDOCT) optic nerve head volumes that obtained from healthy subjects manually delineated within 24 slices develop point clouds for anterior scleral surfaces. A BMO-independent was generated based on peripapillary sclera measure BMO position. General estimating...

Purpose.: We investigated whether disc hemorrhage (DH) is associated with the recent structural alteration of peripheral lamina cribrosa (LC) as assessed by enhanced depth imaging (EDI) spectral-domain optical coherence tomography (SD-OCT). Methods.: Serial horizontal B-scan images were obtained EDI SD-OCT from primary open-angle glaucoma (POAG) patients before and after detection DH (DH group, n = 45), those who had no during 1-year scan interval (non-DH 36). The processed using...

This study examined the association between peripapillary choroidal thickness (PCT) with age and race in a group of African descent (AD) European (ED) subjects normal eyes.Optic nerve head images from enhanced depth imaging spectral-domain optical coherence tomography 166 eyes 84 AD ED were manually delineated to identify principal surfaces Bruch's membrane (BM), opening (BMO), anterior sclera (AS). Peripapillary was measured BM AS at increasing distance away BMO. The mean PCT compared...

Precise device guidance is important for interventional procedures in many different clinical fields including fetal medicine, regional anesthesia, pain management, and oncology. While ultrasound widely used practice real-time guidance, the image contrast that it provides can be insufficient visualizing tissue structures such as blood vessels, nerves, tumors. This study was centered on development of a photoacoustic imaging system delivered excitation light ranges 750 to 900 nm 1150 1300 nm,...

To determine using swept-source optical coherence tomography (SS-OCT) whether there are differences in the location of anterior lamina cribrosa insertion (ALI) primary open-angle glaucoma (POAG) patients and healthy subjects.Fifty three eyes from 53 with POAG, age-matched subjects were included prospectively Seoul National University Bundang Hospital. Twelve radial line B-scans centered on optic disc every half-clock-hour meridian acquired SS-OCT. The ALI position was assessed by measuring...

PURPOSE.To determine microvasculature changes in the deep optic nerve head (ONH) and peripapillary tissues after trabeculectomy, to correlate these with lamina cribrosa (LC) curvature.METHODS.Fifty-six eyes primary open-angle glaucoma that underwent trabeculectomy were included.The evaluated en face images obtained using optical coherence tomography (OCT) angiography (OCTA) before 3 months trabeculectomy.The OCTA-derived vessel density (VD) was calculated each layer segmented into prelaminar...

Purpose: Accurate and efficient guidance of needles to procedural targets is critically important during percutaneous interventional procedures. Ultrasound imaging widely used for real‐time image in a variety clinical contexts, but with this modality, uncertainties about the location needle tip within plane lead significant complications. Whilst several methods have been proposed improve visibility needle, achieving accuracy compatibility current practice an ongoing challenge. In paper,...

Purpose.: Lamina cribrosa (LC) morphology could be implicated in the progression of glaucoma. To date, no established, quantifiable parameter to assess LC shape vivo exists. We aim introduce a new global index for anterior (LC-GSI) and identify associations with ocular factors healthy Indian population. Methods.: Optical coherence tomography (OCT) scans optic nerve head (ONH) were performed on 162 subjects. Optic structures delineated geometric characterization was obtained by measuring...

Purpose: This study examined the peripapillary choroidal thickness (PCT) in nonarteritic ischemic optic neuropathy (NAION) comparison to contralateral eyes and normal eyes. Methods: We used enhanced depth imaging spectral-domain optical coherence tomography image nerve head of 20 NAION, 10 eyes, 102 Following compensation, scans were manually delineated identify relevant surfaces including Bruch's membrane opening (BMO), membrane, anterior sclera. The PCT was defined as measurement between...

The aim of this study was to compare the peripapillary vessel density between eyes with pseudoexfoliation glaucoma (PXG) and primary open-angle (POAG).Peripapillary in radial capillaries assessed using optical coherence tomography angiography, compared patients PXG those POAG, matched for age mean deviation (MD) standard automated perimetry. measured optic disc margin 750 μm from margin.In total, 39 were POAG. Mean untreated intraocular pressure higher group than POAG (21.4±6.7 vs. 14.9±2.9...

Accurate and efficient identification of nerves is an essential component peripheral nerve blocks. While ultrasound (US) imaging increasingly used as a guidance modality, it often provides insufficient contrast for identifying from surrounding tissues such tendons. Electrical stimulators can be in conjunction with US discriminating tissues, but they are to reliably prevent neural punctures, so that alternative methods highly desirable. In this study, interventional multispectral...

Purpose.: To determine if laminar depth (LD) and prelaminar tissue volume (PTV) are associated with age race in healthy human eyes. Methods.: Optic nerve head images from enhanced imaging spectral-domain optical coherence tomography of 166 normal eyes 84 subjects African descent (AD) European (ED) were manually delineated to identify the principal surfaces: internal limiting membrane, Bruch's membrane (BM), anterior sclera (AS), surface lamina cribrosa. These four surfaces defined LD PTV...

Purpose Quantitative evaluation of lamina cribrosa (LC) posterior bowing in primary open-angle glaucoma (POAG) eyes using swept-source optical coherence tomography. Methods Patients with POAG (n = 123 eyes) and healthy individuals a similar age 92 were prospectively recruited. Anterior laminar insertion depth (ALID) was defined as the vertical distance between anterior reference plane connecting Bruch's membrane openings (BMO). The mean LC (mLCD) approximated by dividing area enclosed LC,...

Ultrasound is well suited for guiding many minimally invasive procedures, but its use often precluded by the poor visibility of medical devices. When devices are not visible, they can damage critical structures, with life-threatening complications. Here, we developed first ultrasound probe that comprises both focused and unfocused transducer elements to provide 2D B-mode imaging 3D ultrasonic needle tracking. A fibre-optic hydrophone was integrated into a receive Golay-coded transmissions...