A5100406805- Glaucoma and retinal disorders
- Retinal Diseases and Treatments
- Corneal surgery and disorders
- Retinal Imaging and Analysis
- Ophthalmology and Eye Disorders
- Cerebral Venous Sinus Thrombosis
- Retinal and Macular Surgery
- Intraocular Surgery and Lenses
- Optical Coherence Tomography Applications
- Ocular Surface and Contact Lens
- Retinal Development and Disorders
- Retinal and Optic Conditions
- Neuroinflammation and Neurodegeneration Mechanisms
- Ocular Diseases and Behçet’s Syndrome
- Ocular Infections and Treatments
- Ophthalmology and Visual Impairment Studies
- Single-cell and spatial transcriptomics
- Neurological Disorders and Treatments
- Radiomics and Machine Learning in Medical Imaging
- Moyamoya disease diagnosis and treatment
- Ocular Oncology and Treatments
- Bioinformatics and Genomic Networks
- Ubiquitin and proteasome pathways
- Liver Disease Diagnosis and Treatment
- Nitric Oxide and Endothelin Effects
Seoul National University Bundang Hospital
2016-2025
Soonchunhyang University Hospital
2021-2025
New Generation University College
2013-2024
National University College
2016-2024
Emerging Concepts (United States)
2024
Seoul National University
2010-2023
Woosuk University
2023
Park University
2023
Hanyang University Guri Hospital
2023
Yonsei University
2022
The purpose of this study was to investigate the topographic relationship between decreased parapapillary retinal microvasculature as assessed by optical coherence tomography angiography (OCTA) and nerve fiber layer (RNFL) defect in eyes with primary open-angle glaucoma (POAG) a localized RNFL defect.The peripapillary circulation evaluated using OCTA centered on optic head 98 POAG having 45 healthy control eyes. A vascular impairment (VI) identified presence sign indicating microvasculature....
Purpose: To compare the capability of lamina cribrosa depth (LCD) and (LC) curvature in discriminating between eyes with primary open-angle glaucoma (POAG) healthy eyes. Methods: Seventy-seven 77 patients POAG subjects who were matched for age, sex, axial length included. The LCD index (LCCI) measured B-scan images obtained using swept-source optical coherence tomography at seven locations spaced equidistantly across vertical optic disc diameter. mean values measurements made points LC...
Purpose: The purpose of this article was to compare the frequencies parapapillary deep-layer microvasculature dropout (MvD) detected by optical coherence tomography angiography in eyes with primary open-angle glaucoma (POAG) and healthy determine topographic correlation between MvD glaucomatous retinal nerve fiber layer (RNFL) defect POAG eyes. Methods: Microvasculature peripapillary evaluated 150 patients 45 controls using swept-source identify an MvD. Frequencies MvDs were compared control...
Purpose.: We investigated whether disc hemorrhage (DH) is associated with the recent structural alteration of peripheral lamina cribrosa (LC) as assessed by enhanced depth imaging (EDI) spectral-domain optical coherence tomography (SD-OCT). Methods.: Serial horizontal B-scan images were obtained EDI SD-OCT from primary open-angle glaucoma (POAG) patients before and after detection DH (DH group, n = 45), those who had no during 1-year scan interval (non-DH 36). The processed using...
Parapapillary choroidal microvasculature dropout (MvD) is considered one of pathophysiological manifestations glaucomatous damage.To evaluate the longitudinal change in parapapillary MvD patients with primary open-angle glaucoma (POAG), and to determine whether this associated progressive retinal nerve fiber layer (RNFL) thinning.This prospective observational case series was conducted at a tertiary referral center Korea included 68 POAG who exhibited en face optical coherence tomography...
To evaluate the ability of Stratus optical coherence tomography (OCT version 4.0; Carl Zeiss Meditec, Inc., Dublin, CA) to detect progressive glaucomatous retinal nerve fiber layer (RNFL) atrophy observed by red-free RNFL photography.Intersession test-retest variability each clock hour, quadrant, and average thickness was determined in 53 control subjects. The sensitivity specificity OCT for identification were tested on subjects whom this condition clearly photographs (n=27) another group...
To characterize the microstructure underlying parapapillary deep-layer microvasculature dropout (MvD) identified by optical coherence tomography (OCT) angiography (OCTA) in eyes with primary open-angle glaucoma (POAG).Parapapillary MvD was defined as a focal sectoral capillary without any visible microvascular network en face images obtained using swept-source OCTA. The peripapillary characterized 188 POAG patients deep layer. Twelve radial optic nerve were OCT to examine structure and...
Purpose To investigate the structural and clinical characteristics of peripapillary retinoschisis observed in glaucomatous eyes using spectral-domain optical coherence tomography (SD-OCT). Methods Circumpapillary retinal nerve fiber layer (cpRNFL) macular cross-hair SD-OCT scans infrared fundus images glaucoma patients from Investigating Glaucoma Progression Study (IGPS) healthy volunteers were reviewed. Optic disc obtained enhanced depth imaging (EDI) also evaluated. The course associated...
To determine using swept-source optical coherence tomography (SS-OCT) whether there are differences in the location of anterior lamina cribrosa insertion (ALI) primary open-angle glaucoma (POAG) patients and healthy subjects.Fifty three eyes from 53 with POAG, age-matched subjects were included prospectively Seoul National University Bundang Hospital. Twelve radial line B-scans centered on optic disc every half-clock-hour meridian acquired SS-OCT. The ALI position was assessed by measuring...
PURPOSE.To determine microvasculature changes in the deep optic nerve head (ONH) and peripapillary tissues after trabeculectomy, to correlate these with lamina cribrosa (LC) curvature.METHODS.Fifty-six eyes primary open-angle glaucoma that underwent trabeculectomy were included.The evaluated en face images obtained using optical coherence tomography (OCT) angiography (OCTA) before 3 months trabeculectomy.The OCTA-derived vessel density (VD) was calculated each layer segmented into prelaminar...
// Eun Ji Lee 1 , Hae Seo 2 Ji-Hyeon Park Tam Thuy Lu Vo Sunho An Sung-Jin Bae Hoang Le Hye Shin Hee-Jun Wee Danbi 3 Young-Hwa Chung Jeong A. Kim 4 Myoung-Kuk Jang 5 Soo Hyung Ryu 6 Ensil Yu 7 Se Hwan 8 Zee Yong and Kyu-Won 1, 9 SNU-Harvard NeuroVascular Protection Research Center, College of Pharmacy Institute Pharmaceutical Sciences, Seoul National University, 08826, Korea Department Biochemistry, Keimyung University School Medicine, Daegu 42601, Internal Ulsan Asan Medical 05505, DNA Link...
Abstract The molecular changes that occur with the progression of Alzheimer’s disease (AD) are well known, but an understanding spatiotemporal heterogeneity in brain is lacking. Here, we investigated spatially resolved transcriptome a 5XFAD AD model at different ages to understand regional level. Spatially transcriptomic data were obtained from models and age-matched control mice. Differentially expressed genes identified using spots clustered by anatomical structures. Gene signatures...
Abstract Myopia is one of the risk factors for glaucoma, making accurate diagnosis glaucoma in myopic eyes particularly important. However, challenging due to frequent associations distorted optic disc and parapapillary macular structures. Macular vertical scan has been suggested as a useful tool detect glaucomatous retinal nerve fiber layer loss even highly eyes. The present study was performed develop validate deep learning (DL) system using optical coherence tomography (OCT) scans compare...
Background/Objectives: Variations in image clarity across different OCT devices, along with the inconsistent delineation of RNFL boundaries, pose a challenge to achieving consistent diagnoses for glaucoma. Recently, deep learning methods such as GANs transformation have been gaining attention. This paper introduces transform low-clarity images from one device into high-clarity another, concurrently estimating retinal nerve fiber layer (RNFL) segmentation lines enhanced images. Methods: We...