A5037122101- Glaucoma and retinal disorders
- Retinal Diseases and Treatments
- Corneal surgery and disorders
- Retinal Imaging and Analysis
- Ocular Surface and Contact Lens
- Retinal and Optic Conditions
- Ophthalmology and Visual Impairment Studies
- Visual perception and processing mechanisms
- Ophthalmology and Eye Disorders
- Ophthalmology and Visual Health Research
- Clinical practice guidelines implementation
- Color perception and design
- Global Health Care Issues
- Cerebral Venous Sinus Thrombosis
- Retinal and Macular Surgery
- Acute Ischemic Stroke Management
- Advanced Causal Inference Techniques
- Meta-analysis and systematic reviews
- Health and Well-being Studies
- Public Health in Brazil
- Healthcare Policy and Management
- Health Systems, Economic Evaluations, Quality of Life
- Pharmaceutical Economics and Policy
- Optical Coherence Tomography Applications
- Delphi Technique in Research
University College London
2015-2025
University of West Attica
2020-2025
Moorfields Eye Hospital
2015-2025
Moorfields Eye Hospital NHS Foundation Trust
2017-2024
NIHR Moorfields Biomedical Research Centre
2024
National Health Service
2020
Sunnybrook Health Science Centre
2020
Health Sciences Centre
2020
University of Toronto
2020
National Institute for Health Research
2019
Primary open angle glaucoma and ocular hypertension are habitually treated with eye drops that lower intraocular pressure. Selective laser trabeculoplasty is a safe alternative but rarely used as first-line treatment. We compared the two.In this observer-masked, randomised controlled trial treatment-naive patients or no comorbidities were recruited between 2012 2014 at six UK hospitals. They randomly allocated (web-based randomisation) to initial selective drops. An objective target pressure...
PurposeTo report clinical efficacy, predictors of success, and safety primary selective laser trabeculoplasty (SLT) used in treatment-naive patients with open-angle glaucoma (OAG) or ocular hypertension (OHT).DesignPost hoc analysis a multicenter, prospective, randomized, controlled trial.ParticipantsTreatment-naive OAG OHT.MethodsPatients randomized to SLT topical medication treated predefined target intraocular pressures (IOPs) requiring ≥20% IOP reduction from baseline for all disease...
Importance Primary selective laser trabeculoplasty (SLT) is a safe primary treatment for open-angle glaucoma (OAG) and ocular hypertension (OHT). However, there limited evidence on its use as secondary treatment, ie, after prior of hypotensive eye drops. Objective To evaluate outcomes following SLT using drops at least 3 years. Design, Setting, Participants This post hoc exploratory analysis data from multicenter randomized clinical trial conducted within the UK National Health Service. were...
Purpose The Laser in Glaucoma and Ocular Hypertension (LiGHT) Trial aims to establish whether initial treatment with selective laser trabeculoplasty (SLT) is superior topical medication for primary open-angle glaucoma (POAG) or ocular hypertension (OHT). Design LiGHT a prospective, unmasked, multicentre, pragmatic, randomised controlled trial. 718 previously untreated patients POAG OHT were recruited at six collaborating centres the UK between 2012 2014. trial comprises two arms: SLT...
Newly diagnosed open-angle glaucoma (OAG) and ocular hypertension (OHT) are habitually treated with intraocular pressure (IOP)-lowering eyedrops. Selective laser trabeculoplasty (SLT) is a safe alternative to drops rarely used as first-line treatment.To compare health-related quality of life (HRQoL) in newly diagnosed, treatment-naive patients OAG or OHT, two treatment pathways: topical IOP-lowering medication from the outset (Medicine-1st) primary SLT followed by medications required...
PurposeTo determine the efficacy of repeat selective laser trabeculoplasty (SLT) in medication-naive open-angle glaucoma (OAG) and ocular hypertensive (OHT) patients requiring treatment for early to medium-term failure during Laser Glaucoma Ocular Hypertension (LiGHT) trial.DesignPost hoc analysis SLT arm a multicenter prospective randomized controlled trial.ParticipantsTreatment-naive OAG or OHT 360-degree within 18 months. Retreatment was triggered by predefined IOP disease-progression...
The establishment of minor eye conditions schemes (MECS) within community optometric practices provides a mechanism for the timely assessment patients presenting with range acute conditions. This has potential to reduce waiting times and avoid unnecessary referrals hospital services (HES).To evaluate clinical effectiveness, impact on attendances patient satisfaction service provided by optometrists.Activity outcome data were collected 12 months in Lambeth Lewisham MECS. A questionnaire was...
It is challenging to separate the effects of normal aging retina and visual pathways independently from optical factors, decreased retinal illuminance, early stage disease. This study determined limits describe effect light level on normal, age-related changes in monocular binocular functional contrast sensitivity.We recruited 95 participants aged 20 85 years. Contrast thresholds for correct orientation discrimination gap a Landolt C optotype were measured using 4-alternative, forced-choice...
Abstract Background/Objectives Recent clinical trials in glaucoma have used patient-reported outcome measures (PROMs) of health-related quality life to evaluate interventions. However, existing PROMs may not be sufficiently sensitive capture changes health status. This study aims determine what really matters patients by directly exploring their treatment expectations and preferences. Subjects/Methods We conducted a qualitative using one-to-one semi-structured interviews elicit patients’...
Abstract Over the last decade, delivery of glaucoma care in UK has changed dramatically, with more non-medical ophthalmic practitioners involved patients. Optometrists and other professionals are now laser treatments Hospital Eye Service (HES), but there is currently no standardised national training framework for clinicians. Moorfields UCL’s Institute Ophthalmology have developed delivered an education programme lasers, including Selective Laser Trabeculoplasty (SLT) by practitioners. The...
To explore the views of optometrists, general practitioners (GPs) and ophthalmologists regarding development organisation community-based enhanced optometric services.Qualitative study using free-text questionnaires telephone interviews.A minor eye conditions scheme (MECS) a glaucoma referral refinement (GRRS) are based on accredited community optometry practices.41 6 25 GPs.The most common reason given by optometrists for participation in schemes was to further their professional...
Purpose The laser in glaucoma and ocular hypertension (LiGHT) trial aims to establish whether initial treatment with selective trabeculoplasty (SLT) is superior topical medication for primary open angle (POAG) or (OHT). Design LiGHT a prospective unmasked, multicentre, pragmatic, randomised controlled (RCT). Participants 718 previously untreated patients POAG OHT were recruited at 6 UK centres between 2012 2014. Methods Patients SLT followed by medical therapy without laser. will be...
The aim of this study was to monitor the activity and evaluate clinical safety a minor eye conditions scheme (MECS) conducted by accredited community optometrists in Lambeth Lewisham, London.
The aim of this study was to assess the chromatic sensitivity carriers color deficiency, specifically in relation dependence on retinal illuminance, and reference these findings corresponding red–green (RG) thresholds measured normal trichromatic males. Thirty-six congenital RG deficiency 26 males participated study. illuminance estimated by measuring pupil diameter optical density lens macular pigment. Each subject's vision examined using Color Assessment Diagnosis (CAD) test, Ishihara...
The purpose of this study was to obtain additional information about the health retina (HR) by measuring rate loss chromatic sensitivity with decreasing light level. HRindex is introduced separate effects normal aging from early stage disease. For subjects largely independent age (r2∼0.1), but ∼11% clinically normal, asymptomatic, older exhibit values below 2σ limit. provides a single number that captures how level affects irrespective and can be used screen for preclinical signs retinal
Background Glaucoma referral filtering schemes have operated in the UK for many years. However, there is a paucity of data on false-negative (FN) rate. This study evaluated clinical effectiveness Manchester Enhanced Referral Scheme (GERS), estimating both false-positive (FP) and FN rates. Method Outcome were collected patients newly referred through GERS assessed ‘usual-care’ clinics to determine FP rate (referred subsequently discharged at their first visit). For rate, glaucoma suspects...
Abstract The measurement of macular pigment optical density (MPOD) in the eye is often carried out using techniques based on heterochromatic flicker photometry (HFP). These require use two spectrally‐narrow beams, one at wavelength maximum absorption (MP) and other long region visible spectrum where MP negligible. A new technique for MPOD spatial profiles has been developed by overcoming current shortcomings associated with visual displays. Macular Assessment Profile (MAP) test makes a...
This research aims to evaluate the wider health system effects of introduction an intermediate-tier service for eye care.This employs Minor Eye Conditions Scheme (MECS), care introduced in two London boroughs, Lewisham and Lambeth, April 2013.Retrospective difference-in-differences analysis comparing changes over time use costs between 2011 October 2014 commissioning areas that programme with a neighbouring area did not introduce programme.MECS audit data; unit MECS visits; volumes first...
Variability in central macular pigment optical density (MPOD) has been reported among healthy individuals. These variations seem to be related risk factors of AMD, such as female sex, smoking, and ethnicity. This study investigates the spatial profiles MPOD ethnicities.Using heterochromatic flicker photometry (HFP), was measured at seven retinal locations 54 healthy, young South Asian 19 white subjects similar age. Macular were classified either typical exponential, atypical ring-like, or...
To use optical coherence tomography (OCT) to investigate the qualitative and quantitative differences in defects of retinal nerve fiber layer (RNFL) subjects with high tension primary open angle glaucoma normal glaucoma.RNFL was assessed OCT 21 eyes high-tension (HTG) 20 normal-tension (NTG). Regression analyses were performed interaction disease group location for localized RNFL loss, predict diffuse loss as a function age, mean defect, spherical equivalent, group, location. Local...