Marianne Bakke Johnsen
A5052153296- Osteoarthritis Treatment and Mechanisms
- Musculoskeletal pain and rehabilitation
- Sports injuries and prevention
- Total Knee Arthroplasty Outcomes
- Knee injuries and reconstruction techniques
- Hip disorders and treatments
- Shoulder Injury and Treatment
- Migraine and Headache Studies
- Inflammatory mediators and NSAID effects
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Nutrition, Genetics, and Disease
- Neuroscience of respiration and sleep
- Genetic Associations and Epidemiology
- Bone health and treatments
- Rheumatoid Arthritis Research and Therapies
- Suicide and Self-Harm Studies
- Medical and Biological Sciences
- Cerebral Palsy and Movement Disorders
- Sleep and related disorders
- Occupational Health and Performance
- School Health and Nursing Education
- Obesity, Physical Activity, Diet
- Spine and Intervertebral Disc Pathology
- Bioinformatics and Genomic Networks
- Shoulder and Clavicle Injuries
OsloMet – Oslo Metropolitan University
2023-2025
Copenhagen University Hospital
2025
Rigshospitalet
2025
Oslo University Hospital
2015-2024
Norwegian University of Science and Technology
2018-2022
University of Oslo
2016-2022
Metropolitan University
2022
University of Illinois Chicago
2014
Evangelisches Krankenhaus Kalk
2012
Osteoarthritis affects over 300 million people worldwide. Here, we conduct a genome-wide association study meta-analysis across 826,690 individuals (177,517 with osteoarthritis) and identify 100 independently associated risk variants 11 osteoarthritis phenotypes, 52 of which have not been the disease before. We report thumb spine differences in genetic effects between weight-bearing non-weight-bearing joints. sex-specific early age-at-onset loci. integrate functional genomics data from...
Knowledge of how physical activity (PA) and sport participation are related to mental health throughout adolescence is scarce. Our objective was describe PA levels in a population-based sample adolescents, explore they relate different age groups.A cross-sectional study.The adolescent part the Nord-Trøndelag Health Study, Norwegian survey, conducted from 2006 2008. Of 10 464 invited participants (age 13-19 years), 7619 (73%) participated, whom 3785 (50%) were boys.Mental outcomes included...
Back pain is a common and debilitating disorder with largely unknown underlying biology. Here we report genome-wide association study of back using diagnoses assigned in clinical practice; dorsalgia (119,100 cases, 909,847 controls) intervertebral disc (IDD) (58,854 922,958 controls). We identify 41 variants at 33 loci. The most significant (OR
Prevalence of musculoskeletal pain among adolescents is high, and in adolescence increases the risk chronic adulthood. Studies have shown conflicting evidence regarding associations between physical activity pain, few evaluated potential impact sport participation on adolescent population samples.To examine level, participation, neck shoulders, low back, lower extremities a population-based sample adolescents.Cross-sectional study; Level 4.Data from Nord-Trøndelag Health Study (Young-HUNT3)...
Migraine is three times more prevalent in people with bipolar disorder or depression. The relationship between schizophrenia and migraine less certain although glutamatergic serotonergic neurotransmission are implicated both. A shared genetic basis to mental disorders has been suggested but previous studies have reported weak non-significant correlations five risk loci. Using the largest samples date novel statistical tools, we aimed determine extent which migraine's polygenic architecture...
Summary Late-onset Alzheimer’s disease is a prevalent age-related polygenic that accounts for 50-70% of dementia cases 1 . caused by combination many genetic variants with small effect sizes and environmental influences. Currently, only fraction the underlying have been identified 2,3 Here we show increased sample allowed identification seven novel loci contributing to disease. We highlighted eight potentially causal genes where gene expression changes are likely explain association. Human...
Chronic pain is often present at more than one anatomical location, leading to chronic overlapping conditions. Whether conditions represent a distinct pathophysiology from the occurrence of only site unknown. Using genome-wide approaches, we compared genetic determinants single-site versus multisite in UK Biobank. We found that different signals underlie and with much stronger contributions for latter. Among 23 loci associated pain, nine replicated HUNT cohort, DCC netrin 1 receptor (DCC) as...
ABSTRACT Background Compared to children or older adults, young adults (age 18–29) who undergo liver transplantation are more likely have poor psychological health and a higher risk of graft failure. Understanding patient needs perspectives is important for caring improving long‐term outcomes. Aims Objectives To (1) understand recipients' experiences, views throughout the process (2) identify possible improvements in their care. Methodological Design Justification Three focus group...
Introduction Greater trochanteric pain syndrome (GTPS) is a common and disabling condition characterised by lateral hip pain. The often persists for several months, there low evidence any superior treatment. aim of this study protocol to describe randomised controlled trial (RCT) investigating the effectiveness self-management programme versus usual care patients with GTPS. Methods analysis designed as an observer-blinded, parallel group, superiority RCTcomparing (n=55) (n=55). Eligible GTPS...
An anterior cruciate ligament (ACL) injury is a severe that may require ACL reconstruction (ACLR) to enable the return sport. Risk factors for ACLR have not firmly been established in general adolescent population.To investigate incidence and risk population-based cohort of adolescents.Cohort study; Level evidence, 3.We prospectively followed 7644 adolescents from part Nord-Trøndelag Health Study, included 2006 2008. The main interest were level sport participation (level I, II, or III)...
Biochemical changes associated with obesity may accelerate osteoarthritis beyond the effect of mechanical factors. This study investigated whether metabolic syndrome and its components (visceral obesity, hypertension, dyslipidemia insulin resistance) were risk factors for subsequent total hip replacement (THR) or knee (TKR) due to primary osteoarthritis.In this prospective cohort study, data from second survey Nord-Trøndelag Health Study 2 (HUNT2) linked Norwegian Arthroplasty Register...
Headache has been associated with various lifestyle and psychosocial factors, one of which is smoking. The aim the present study was to investigate whether association between smoking intensity headache likely be causal.A total 58 316 participants from Nord-Trøndelag Health (HUNT) information on status were genotyped for rs1051730 C>T single-nucleotide polymorphism (SNP). SNP used as an instrument in a Mendelian randomization analysis. T alleles estimated by odds ratios 95% confidence...
To study whether thyroid function was associated with risk of hip or knee replacement due to primary osteoarthritis. In a prospective cohort study, data from the second and third survey Nord-Trøndelag Health Study were linked Norwegian Arthroplasty Register in order identify total as result Among 37 891 participants without previously known disease we recorded 978 replacements (THRs) 538 (TKRs) during median follow-up time 15.7 years. The analyses adjusted for sex, age, BMI (body mass...
The relationship between leisure time physical activity (LPA) and hip knee OA subsequent joint replacement has not yet been clearly defined. Some studies have found the risk of (TKR) to increase with high levels LPA, while others no overall either TKR or (THR). aim was investigate association LPA severe end-stage OA, defined as THR due primary in a large population-based cohort. Participants Nord-Trøndelag Health Study (HUNT) were followed prospectively identify using Norwegian Arthroplasty...
To investigate the total effect of smoking on hip or knee replacement (THR/TKR) due to primary osteoarthritis (OA) and quantify indirect through body mass index (BMI). Participants from Nord-Trøndelag Health Study (the HUNT Study) were linked Norwegian Arthroplasty Register detect first THR TKR OA. A mediation analysis was used decompose into a direct effect. BMI considered mediator in analysis. All effects estimated as hazard ratios (HRs) with 95% confidence intervals (CIs). The mediated...