A5089342465- Retinal Development and Disorders
- melanin and skin pigmentation
- Vestibular and auditory disorders
- Retinal Diseases and Treatments
- Glaucoma and retinal disorders
- Retinopathy of Prematurity Studies
- Ophthalmology and Eye Disorders
- Retinal Imaging and Analysis
- Dental Implant Techniques and Outcomes
- Optical Coherence Tomography Applications
- Gaze Tracking and Assistive Technology
- Ophthalmology and Visual Impairment Studies
- Intraocular Surgery and Lenses
- Lysosomal Storage Disorders Research
- RNA regulation and disease
- Periodontal Regeneration and Treatments
- Connexins and lens biology
- Parvovirus B19 Infection Studies
- Immunodeficiency and Autoimmune Disorders
- Corneal Surgery and Treatments
- Cerebral Venous Sinus Thrombosis
- Biochemical Analysis and Sensing Techniques
- Frailty in Older Adults
- Dental materials and restorations
- Retinal and Optic Conditions
University Hospital Southampton NHS Foundation Trust
2017-2025
Taipei Medical University
2025
University of Southampton
2016-2025
Inha University
2025
Tan Tock Seng Hospital
2024
Southampton General Hospital
2024
University of Newcastle Australia
2021-2023
Newcastle University Singapore
2023
Manchester Royal Infirmary
2011-2023
Manchester University NHS Foundation Trust
2020-2023
Purpose The purpose of the study is to investigate psychological safety, organisation support and emotion in workplace during transition from office home working COVID-19 pandemic crisis. Past studies on mostly focus types discreet emotion, relation positive negative emotions (e.g. Connelly Torrence, 2018; Rubino et al. , 2013). Other reported that are derived social comparison processes (Matta Dyne, 2020). During a crisis, emotional responses workers organisational different group employees...
A guideline is proposed that comprises the minimum items to be reported in research studies involving an eye tracker and human or non-human primate participant(s). This was developed over a 3-year period using consensus-based process via open invitation international tracking community. will reviewed at maximum intervals of 4 years.
Purpose: To characterize the time course of normal foveal development in vivo term infants and young children using handheld spectral-domain optical coherence tomography (HH-SDOCT). Methods: We obtained 534 HH-SDOCT scans from 261 infants, children, adults with a mean age 4.9 years (range, 0–27 years). Each retinal layer was manually segmented ImageJ correlated gestational (GA) visual acuity (VA). The developmental trajectories each at fovea, parafovea, perifovea were calculated fractional...
PurposeTo determine feasibility of optic nerve head (ONH) imaging and to characterize ONH development in full-term infants without sedation using handheld spectral-domain optical coherence tomography (SD OCT).DesignProspective cross-sectional study.ParticipantsThree hundred fifty-two children aged between 1 day 13 years.MethodsAll participants were imaged SD OCT during a single scan session. The percentage successful scans was calculated. Interexaminer reproducibility differences right left...
To evaluate structural grading and quantitative segmentation of foveal hypoplasia using handheld OCT, versus preferential looking (PL), as predictors future vision in preverbal children with infantile nystagmus.Longitudinal cohort study.Forty-two patients nystagmus (19 albinism, 17 idiopathic nystagmus, 6 achromatopsia) were examined.Spectral-domain OCT was performed up to 36 months age. Foveal tomograms graded our 6-point system for segmented analysis: photoreceptor length, outer segment...
Proliferative vitreoretinopathy (PVR), a major reason for failure of retinal detachment surgery, is characterized by the formation scarlike tissue that contains transdifferentiated pigment epithelial (RPE) cells. The scar occurs in response to growth factors such as transforming factor (TGF)-beta and epidermal (EGF). authors postulate transdifferentiation RPE cells may arise via epithelial-to-mesenchymal transition (EMT). Bone morphogenetic proteins (BMPs) are expressed retina have an...
Abstract Oculocutaneous albinism (OCA) and ocular (OA) are inherited disorders of melanin biosynthesis, resulting in loss pigment severe visual deficits. OCA encompasses a range subtypes with overlapping, often hypomorphic phenotypes. OCA1 is the most common cause European populations through autosomal recessive mutations Tyrosinase ( TYR) gene. However, there high level reported missing heritability, where only single heterozygous mutation found TYR . This also case for other including OCA2...
Purpose.: To evaluate the reliability of spectral domain handheld OCT (HH-OCT) in assessing foveal morphology children with and without nystagmus.
Purpose: To examine the factors impacting cone contrast sensitivity in Koreans aged > 60 years who are scheduled for cataract surgery and do not have congenital color vision deficiencies.Methods: The ColorDx Cone test HD® (CCT-HD; Konan Medical, Inc., CA, USA) was administered to 33 Korean individuals (33 eyes) evaluate CCT scores before after surgery, as well changes according degree of progression by type. Correlations between age, best corrected visual acuity (BCVA), regional retinal...
Visual Electro-Diagnostic Testing (EDTs) are a highly specialised service in the NHS. The high cost of tests and paucity trained visual electrophysiologists has resulted very few services across UK and, when combined with increasing patient backlogs, caused significant travel burden variable waiting times. Here, we study potential for impact on patients by adding screening step to traditional referral pathways using an Electroretinogram (ERG) test from relatively inexpensive, portable,...
Purpose The purpose of this paper is to investigate the mediating factor interactional justice (IJ) between specific types human resource (HR) practices: training and development (TD), compensation benefits (CB), work process (WP), perceived organizational support (POS). There has been scant attention paid in past studies examining components HR practices on IJ. Design/methodology/approach study was conducted a healthcare organization, employed quantitative analysis based surveys interviews...
The authors report two patients with cerebellar infarctions in the territory of medial branch posterior inferior artery who had vertigo, spontaneous ipsilesional nystagmus, and contralesional truncal lateropulsion. Although one slight dysmetria, overall signs closely mimicked those acute peripheral vestibulopathy. suggest that interruption nodulouvular inhibitory projections to vestibular nuclei may account for signs.
Abstract Albinism is a group of disorders characterized by pigment deficiency and abnormal retinal development. Despite being common cause for visual impairment worldwide, there paucity treatments patients typically suffer lifelong disability. Residual plasticity the developing retina in young children with albinism has been demonstrated, suggesting post‐natal window therapeutic rescue. L‐3, 4 dihydroxyphenylalanine (L‐DOPA), key signalling molecule which essential normal development, known...
Oculocutaneous albinism type 1 (OCA1) is caused by pathogenic variants in the TYR (tyrosinase) gene which encodes critical and rate-limiting enzyme melanin synthesis. It most common OCA subtype found Caucasians, accounting for ~50% of cases worldwide. The apparent 'missing heritability' well described, with ~25-30% clinically diagnosed individuals lacking two clearly variants. Here we undertook empowered genetic studies an extensive multigenerational Amish family, alongside a review...