A5028457043- Circadian rhythm and melatonin
- Retinal Development and Disorders
- Biochemical Analysis and Sensing Techniques
- Regulation of Appetite and Obesity
- melanin and skin pigmentation
- Photoreceptor and optogenetics research
- Retinal Diseases and Treatments
- Adipose Tissue and Metabolism
- Sleep and Wakefulness Research
- Genetics, Aging, and Longevity in Model Organisms
- Birth, Development, and Health
- Dietary Effects on Health
- Hypothalamic control of reproductive hormones
- Light effects on plants
- Diet, Metabolism, and Disease
- Adipokines, Inflammation, and Metabolic Diseases
- Electromagnetic Fields and Biological Effects
- Glaucoma and retinal disorders
- PI3K/AKT/mTOR signaling in cancer
- Olfactory and Sensory Function Studies
- Spaceflight effects on biology
- Neurobiology and Insect Physiology Research
- RNA regulation and disease
University of Southampton
2019-2023
Morehouse School of Medicine
2016-2019
Universidad Complutense de Madrid
2013-2017
Abstract Recent genetic studies have highlighted the potential involvement of melatonin receptor 1 ( MT ) and 2 in pathogenesis type diabetes. Here, we report that mice lacking KO tend to accumulate more fat mass than WT exhibit marked systemic insulin resistance. Additional experiments revealed main signaling pathway affected by loss was activation phosphatidylinositol‐3‐kinase PI 3K). Transcripts both catalytic regulatory subunits 3K were strongly downregulated within mice. Moreover,...
Ghrelin is a gut-brain peptide hormone, which binds to the growth hormone secretagogue receptor (GHS-R) regulate wide variety of biological processes in fish. Despite these prominent physiological roles, no studies have reported anatomical distribution preproghrelin transcripts using situ hybridization non-mammalian vertebrate, and its mapping within different encephalic areas remains unknown. Similarly, information available on possible 24-h variations expression any vertebrate species. The...
Oculocutaneous albinism type 1 (OCA1) is caused by pathogenic variants in the TYR (tyrosinase) gene which encodes critical and rate-limiting enzyme melanin synthesis. It most common OCA subtype found Caucasians, accounting for ~50% of cases worldwide. The apparent 'missing heritability' well described, with ~25-30% clinically diagnosed individuals lacking two clearly variants. Here we undertook empowered genetic studies an extensive multigenerational Amish family, alongside a review...
There are no disease-modifying treatments available for geographic atrophy (GA), the advanced form of dry age-related macular degeneration. Current murine models fail to fully recapitulate features GA and thus hinder drug discovery. Here we describe a novel mouse model retinal degeneration with hallmark GA. We used an 810 nm laser create lesion central sparing (RLCS), simulating parafoveal observed in patients progressive Laser-induced RLCS resulted GA-like pathology development confluent...
The functional organization of the circadian system and location main oscillators vary through phylogeny. Present study investigates by in situ hybridization anatomical clock gene gPer1b forebrain midbrain, pituitary, two peripheral locations, anterior intestine liver, a teleost fish, goldfish (Carassius auratus). Moreover, daily expression profiles this were also studied quantitative Real Time-PCR. Goldfish maintained under 12L–12D photoperiod fed at 2 h after lights switched on. A wide...
The liver is the most important link between circadian system and metabolism. As a food-entrainable oscillator, hepatic clock needs to be entrained by food-related signals. objective of present study was investigate possible role ghrelin (an orexigenic peptide mainly synthesized in gastrointestinal tract) as an endogenous synchronizer oscillator teleosts. To achieve this aim, we first examined presence receptors goldfish. Then, regulation gene expression goldfish studied. Finally,...
Ghrelin O-acyltransferase (GOAT) is the enzyme responsible for acylation of ghrelin, a gut-brain hormone with important roles in many physiological functions vertebrates. Many aspects GOAT remain to be elucidated, especially fish, and particularly its anatomical distribution within different brain areas has never been reported date. The present study aimed characterize mapping using RT-qPCR immunohistochemistry teleost, goldfish (Carassius auratus). Results show that goat transcripts are...
Ghrelin (orexigenic) and nesfatin-1 (anorexigenic) are two peptides with opposing actions on food intake regulation mainly expressed in the hypothalamus gut of mammals fish. Both involved a wide range physiological processes vertebrates, including metabolism, growth, reproduction. However, anatomical relationship between these nutrient assimilation not well understood. Thus, aim this work was to determine localization ghrelin, nesfatin-1, several enzymes digestive process (lipoprotein...
L-DOPA is deficient in the developing albino eye, resulting abnormalities of retinal development and visual impairment. Ongoing after birth has also been demonstrated eye offering a potential therapeutic window humans. To study whether human equivalent doses L-DOPA/Carbidopa administered during crucial postnatal period neuroplasticity can rescue function, OCA C57BL/6 J-c2J OCA1 mice were treated with 28-day course oral at 3 different from 15 to 43 days age (PNA) for lengths treatment,...
Abstract L-DOPA is deficient in the developing albino eye, resulting abnormalities of retinal development and visual impairment. Ongoing after birth has also been demonstrated eye offering a potential therapeutic window humans. To study whether human equivalent doses L-DOPA/Carbidopa administered during crucial postnatal period neuroplasticity can rescue function, OCA C57BL/6J-c2J OCA1 mice were treated with 28-day course oral at 3 different from 15 to 43 days age (PNA) for lengths...