Abstract Inhibitors of programmed cell death ligand 1 (PD-L1) and vascular endothelial growth factor receptor 2 (VEGFR2) are commonly used in the clinic, but they beneficial for only a minority glioblastoma multiforme (GBM) patients. GBM has significant immunosuppressive properties, there many cells dysfunctional effector T tumor microenvironment (TME), which is one important reasons failure clinical treatment GBM. Here, we have identified P21 activated kinase 4 (PAK4) as pivotal immune...

In this study, ultra-high molecular weight polyethylene (UHMWPE) fibers reinforced rigid polyurethane (RPU) composites were prepared with the goal of improving strength and toughness. The satisfactory mechanical properties mainly contributed to copper-polydopamine composite coating. Polydopamine on surface UHMWPE could react form chemical bonds, leading improvement material strength. Moreover, deposited metal layer provided more paths for crack propagation in composites, thus improved...

Abstract The simultaneous promotion in mechanical and electrical properties of rigid polyurethane (RPU) is an important task for expanding potential application. In this work, carbon fibers (CFs) reinforced RPU composites were prepared with the goal improving properties. Metallized CFs meet our performance requirements can be easily achieved via electrodeposition. However, weak bonding strength fiber‐metal‐RPU interface restricts their Inspired by reducibility wonderful adhesion dopamine...

In this article, short carbon fibers (CFs) reinforced rigid polyurethane (RPU) composites were prepared with the aim of improving both strength and toughness. A tannic acid (TA)‐nickel (Ni) composite coating was spontaneously co‐deposited onto CFs surface by a one‐step electrodeposition method to strengthen interface bonding composites. The satisfactory mechanical properties mainly attributed superior interfacial adhesion. On one hand, TA could play role in refining Ni grain during...

Abstract In this work, spodumene/mullite ceramics with low thermal expansion were successfully prepared from spodumene, quartz, talc, and clay. The effects of spodumene content sintering temperature on the mechanical properties investigated. formed phases then detected by X‐ray diffraction analysis microstructures sintered bodies determined scanning electron microscopy. interaction apparent porosity bulk density studied response surface methodology. results demonstrate that an appropriate...

Abstract In this paper, spodumene/mullite ceramics with good thermal shock resistance were prepared from spodumene, quartz, talc, and clay when the sintering temperature was 1270℃. process, effect of holding time on densification, mechanical properties, phase transformation, microstructure, composite investigated. The transition microstructures identified via X‐ray diffraction (XRD) scanning electron microscopy (SEM). interaction between bulk density studied by response surface methodology....

The in-situ formed MgAl2O4–CaAl12O19 (MA–CA6) composites were fabricated in this study. To clarify the influence of evolution CA6 phase on properties MA–CA6 composites, sintering temperature was carried out at 1200–1700 °C for 2 h. results show that growth and development grains improves densification flexural strength composites. formation MA occurs 1200 °C, while is by reaction CaAl4O7 (CA2) Al2O3 appears 1400 °C. plate-like intersect with each other, presenting regular hexagonal...

<title>Abstract</title> Purpose To study the clinical performance, imaging findings, pathological characteristics, treatment and prognosis of aneurysmal subarachnoid hemorrhage (aSAH) complicated with neurogenic pulmonary edema (NPE). Methods 36 aSAH patients NPE were retrospectively studied. These divided into good group (Glasgow Outcome Scale [GOS] ≥ 4) poor (GOS ≤ 3). All underwent preoperative computed tomography (CT) Computed Tomographic Angiography (CTA) or digital subtraction...

Abstract In this study, varying amounts of MnO 2 up to 5 wt.% were added magnesium aluminate spinel (MA) bodies using a solid‐state sintering method at 1200–1600°C. The effect addition on the phase composition, microstructure, distribution elements, and ionic valence MA was investigated via X‐ray diffraction, scanning electron microscopy, energy‐dispersive spectroscopy, photoelectron respectively. results showed that Mg 2+ ions in crystals replaced by Mn ions, resulting formation (Mg 1‐ x...

For energy-saving or water-saving consideration, performance optimization of air-cooled condenser is important. The calculation results for the cool-end a 600MW SC air cooling unit show that has economic benefits and USC units. Based on same idea, idea method units with 1000MW suggested in this paper, order to improve operation direct system thermal power plant.

High-speed cutting technology is widely used in aviation, mold, automotive industries and other fields for its high machining efficiency, smaller force, less heat precision. However, the production site China, high-speed machine tools do not really play role some enterprises, without real sense of machining. Aluminum alloy 2A70 as research object, using single-factor test, study effect law milling parameters on force here. The results show that: varying milling, showing a periodic variation,...

This paper explores the drilling characteristics of GH3039 supper alloy. The machining is a difficulty which commonly used in aircraft and engineer components aerospace industry. spindle speed feed per tooth are major influence factors studied to gain large removal rate predict characteristics. So single factor test carried out about tooth. results experiment show that force decreased with increasing up 900r/min larger than other metal process. small may obtain force. too low not adopted...

Abstract Ceramics with aluminum borate whiskers (ABWs) were prepared from H 3 BO and Al 2 O reagent, without 6 wt% MnO used as an addition. The microstructures, phase composition, crystal structure of the ceramics analyzed via scanning electron microscopy, energy dispersive spectroscopy, X‐ray diffraction, respectively. results show that is effective addition for enhancing flexural strength ceramics. could lead to distortion lattice, improve mechanical a solid solution strengthening...