A5054291303- Intracerebral and Subarachnoid Hemorrhage Research
- Intracranial Aneurysms: Treatment and Complications
- Traumatic Brain Injury and Neurovascular Disturbances
- Acute Ischemic Stroke Management
- RNA Interference and Gene Delivery
- Neuroinflammation and Neurodegeneration Mechanisms
- DNA and Nucleic Acid Chemistry
- Advanced biosensing and bioanalysis techniques
- Caveolin-1 and cellular processes
- Ferroptosis and cancer prognosis
- Inflammatory Biomarkers in Disease Prognosis
- Drug Transport and Resistance Mechanisms
- Balance, Gait, and Falls Prevention
- Pancreatic and Hepatic Oncology Research
- Blood donation and transfusion practices
- Sepsis Diagnosis and Treatment
- Autism Spectrum Disorder Research
- Immune cells in cancer
- Heart Rate Variability and Autonomic Control
- Hip and Femur Fractures
- Mechanisms of cancer metastasis
- Neurosurgical Procedures and Complications
- Cancer Research and Treatments
- S100 Proteins and Annexins
- Neonatal and fetal brain pathology
Chongqing Medical University
2019-2025
Dalian Medical University
2019-2025
Second Affiliated Hospital of Chongqing Medical University
2019-2025
Loma Linda University
2023-2024
Loma Linda University Medical Center
2024
Hematoma clearance has been a proposed therapeutic strategy for hemorrhagic stroke. This study investigated the impact of CX3CR1 (CX3C chemokine receptor 1) activation mediated by r-FKN (recombinant fractalkine) on hematoma resolution, neuroinflammation, and underlying mechanisms involving AMPK (AMP-activated protein kinase)/PPARγ (peroxisome proliferator-activated gamma) pathway after experimental germinal matrix hemorrhage (GMH).A total 313 postnatal day 7 Sprague Dawley rat pups were...
Ferroptosis is a distinct form of cell death characterized by iron-dependent lipid peroxidation and plays crucial role in the early brain injury (EBI) following subarachnoid hemorrhage (SAH). As newly discovered endogenous ligand for C-KIT receptor tyrosine kinase, meteorin-like protein (Metrnl) exerts regulatory functions oxidative stress protects against various diseases. However, specific Metrnl/C-KIT axis neuronal ferroptosis during EBI SAH remains to be elucidated. Sprague Dawley rats...
Background and purpose: Emerging evidence suggests that systemic inflammation is associated with the pathophysiological process of delayed cerebral ischemia (DCI) after aneurysmal subarachnoid hemorrhage (aSAH). This study aimed to investigate association white blood cell (WBC) count neutrophil-to-lymphocyte ratio (NLR) occurrence DCI in SAH patients. Methods: A total 122 patients diagnosed aSAH within 72 h onset were retrospectively enrolled. The WBC, neutrophil (NC), lymphocyte (LC) was...
Glioma is one of the deadliest intrinsic brain tumours due to its invasive growth. The effect glioma treatment poor because presence blood-brain barrier and blood tumour insufficient drug targeting. DNA tetrahedrons (TDN) show great potential for delivery may be a novel therapeutic strategy glioma. In this study, we used TDN deliver doxorubicin (DOX) therapy. Gint4.T, an aptamer that could recognize platelet-derived growth factor receptor β on cell, was modify (Apt-TDN) targeted delivery....
Abstract Background Reactive astrocytes participate in various pathophysiology after subarachnoid hemorrhage (SAH), including neuroinflammation, glymphatic–lymphatic system dysfunction, brain edema, BBB disruption, and cell death. Astrocytes transform into two new reactive phenotypes with changed morphology, altered gene expression, secretion profiles, termed detrimental A1 beneficial A2. This study investigates the effect of 67LR activation by PEDF-34, a PEDF peptide, on neuroinflammation...
Immune-nutritional status is correlated with a clinical outcome in critical illness. Recently, controlling nutritional (CONUT) score and prognostic nutrition index (PNI) has been reported to predict prognosis following cancer other diseases. The aim of this study was explore the relationship between CONUT PNI 6-month patients severe traumatic brain injury (STBI).We retrospectively analyzed data 78 STBI, including PNI. Patients were divided into high group low group. also respectively....
Aneurysmal subarachnoid hemorrhage (aSAH) has high rates of disability and mortality, aneurysm rebleeding is associated with poor functional outcomes. Thrombelastography platelet mapping (TEG-PM) measures function; however, it not yet been researched in aSAH. We aimed to use TEG-PM detect changes function patients aSAH the difference without rebleeding.We retrospectively included who underwent a test on admission. Rebleeding was diagnosed according clinical imaging data. data unruptured...
Ferroptosis contributes to brain injury after germinal matrix hemorrhage (GMH). Mitochondrial ferritin (FTMT), a novel mitochondrial outer membrane protein, reduces oxidative stress in neurodegenerative diseases. In vitro, Deferiprone has been shown upregulate FTMT. However, the effects of FTMT upregulation by on neuronal ferroptosis GMH and its underlying mechanism not investigated. our study, 389 Sprague-Dawley rat pups postnatal day 7 were used establish collagenase-induced model an...
Subarachnoid hemorrhage (SAH) is a devastating stroke, in which acidosis one of detrimental complications. The extracellular pH reduction can activate G protein-coupled receptor 4 (GPR4) the brain. Yet, extent to proton-activated GPR4 contributes early brain injury (EBI) post-SAH remains largely unexplored. Ferroptosis, iron-dependent programmed cell death, has recently been shown contribute EBI. We aimed investigate effects inhibition on neurological deficits and neuronal ferroptosis after...
Background and Purpose: The purpose of the study was to evaluate usefulness thromboelastography with platelet mapping (TEG-PM) for predicting hematoma expansion (HE) poor functional outcome in patients intracerebral hemorrhage (ICH). Methods: Patients primary ICH who underwent baseline computed tomography (CT) TEG-PM within 6 h after symptom onset were enrolled observational cohort study. We performed univariate multivariate logistic regression models assess association admission function HE...
Abstract Objectives: Systemic inflammatory response is closely related to the pathogenesis and prognosis in critical patients. Recently, systemic immune-inflammation index (SII), an indicator of response, was proved predict outcome cancerous non-cancerous diseases. The aim this study evaluate relationship between SII on admission 6-month patients with aneurysmal subarachnoid hemorrhage (aSAH). Methods: clinical data 76 aSAH analyzed. Patients were divided into high group low group. assessed...
Abstract Glioma is one of the most deadly tumors due to invasive growth. The treatment effect poor presence blood brain barrier (BBB) and tumor (BTB) insufficient drug targeting. DNA tetrahedron (TDN) considered have great potential for delivery maybe a novel therapeutic strategy glioma. In this study, we developed doxorubicin loaded-DNA modified by Gint4.T aptamer(DOX@Apt-TDN) that could target PDGFRβ therapy TDN Apt-TDN were self-assembled one-step synthesis. characterization stability...