A5101477551- Nanoplatforms for cancer theranostics
- Ferroptosis and cancer prognosis
- Venous Thromboembolism Diagnosis and Management
- Intracerebral and Subarachnoid Hemorrhage Research
- Cancer Immunotherapy and Biomarkers
- Digestive system and related health
- Inflammasome and immune disorders
- Advanced biosensing and bioanalysis techniques
- Mesenchymal stem cell research
- Gut microbiota and health
- Diagnosis and Treatment of Venous Diseases
- Respiratory Support and Mechanisms
- Blood Coagulation and Thrombosis Mechanisms
- RNA Interference and Gene Delivery
- Atrial Fibrillation Management and Outcomes
- Epigenetics and DNA Methylation
- Immune cells in cancer
- Immunotherapy and Immune Responses
- RNA Research and Splicing
- Radioactivity and Radon Measurements
- Vasculitis and related conditions
- Probiotics and Fermented Foods
- Telomeres, Telomerase, and Senescence
- Neurosurgical Procedures and Complications
- Mechanisms of cancer metastasis
Shanghai East Hospital
2020-2025
Washington University in St. Louis
2025
Second Affiliated Hospital of Chongqing Medical University
2020-2024
Dalian Medical University
2020-2024
Chongqing Medical University
2020-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2022-2024
Daping Hospital
2024
China Institute of Atomic Energy
2024
Peking Union Medical College Hospital
2022-2024
Tongji University
2020-2024
Abstract Given that traditional anticancer therapies fail to significantly improve the prognoses of triple negative breast cancer (TNBC), new modalities with high efficiency are urgently needed. Herein, by mixing metal‐phenolic network formed tannic acid (TA), bleomycin (BLM), and Fe 3+ glutathione peroxidase 4 (GPX4) inhibitor (ML210) loaded hollow mesoporous Prussian blue (HMPB) nanocubes, HMPB/ML210@TA‐BLM‐Fe (HMTBF) nanocomplex is prepared favor ferroptosis/apoptosis synergism in TNBC....
Neuroinflammation has been proven to exert an important effect on brain injury after intracerebral hemorrhage (ICH). Previous studies reported that Didymin possessed anti-inflammatory properties acute hepatic injury, hyperglycemia-induced endothelial dysfunction, and death. However, the role of in microglial pyroptosis neuroinflammation ICH is unclear. The current study aimed investigate mediated by mouse models shed some light underlying mechanisms. In this study, we observed treatment...
Ferroptosis has been implicated in the pathogenesis of secondary brain injury following intracerebral hemorrhage (ICH), and regulating this process is considered a potential therapy for alleviating further injury. A previous study showed that CDGSH iron sulfur domain 2 (CISD2) can inhibit ferroptosis cancer. Thus, we investigated effects CISD2 on mechanisms underlying its neuroprotective role mice after ICH. expression markedly increased over-expression significantly decreased number...
The exclusion of immune cells from the tumor can limit effectiveness immunotherapy in triple negative breast cancer (TNBC). cyclic GMP-AMP synthase-stimulator interferon genes (cGAS-STING) pathway plays a crucial role priming adaptive anti-tumor immunity through production type I interferons (IFNs), facilitating maturation dendritic (DCs) and function T cells. Although increased expression programmed death-ligand 1 (PD-L1) upon STING activation is favorable for amplifying efficacy checkpoint...
Tetracyclines (TCs) are an important class of antibiotics threatened by enzymatic inactivation. These tetracycline-inactivating enzymes, also known as tetracycline destructases (TDases), a subfamily A flavin monooxygenases (FMOs) that catalyze hydroxyl group transfer and oxygen insertion (Baeyer-Villiger type) reactions on TC substrate scaffolds. Semisynthetic modification TCs (e.g., tigecycline, omadacycline, eravacycline, sarecycline) has proven effective in evading certain resistance...
Varicose veins are found to be associated with increased risk of venous thromboembolism (VTE) in many observational studies, but whether varicose causally VTE remains unclear. Therefore, we used a series Mendelian randomization (MR) methods investigate that association.23 independent single-nucleotide polymorphisms (SNPs) for were obtained from the Pan UK Biobank analysis. The outcomes datasets deep vein thrombosis (DVT), pulmonary embolism (PE) and FinnGen study. Before analysis, body mass...
The COVID-19 pandemic has become an unprecedented global medical emergency, resulting in more than 5 million deaths. Acute respiratory distress syndrome (ARDS) caused by COVID-19, characterized the release of a large number pro-inflammatory cytokines and production excessive toxic ROS, is most common serious complication leading to death. To develop new strategies for treating ARDS mouse model was established using lipopolysaccharide (LPS). Subsequently, we have constructed novel nanospray...
Despite immunotherapy having revolutionized cancer therapy, the efficacy of in triple-negative breast (TNBC) is seriously restricted due to insufficient infiltration mature dendritic cells (DCs) and highly diffusion immunosuppressive tumor microenvironment. Herein, an immunomodulatory nanoplatform (HA/Lipo@MTO@IMQ), which DCs could be maximally activated, was engineered remarkably eradicate via combination suppressive immune microenvironment reversal immunotherapy, chemotherapy, photothermal...
A multifunctional tumor-targeting SN38-conjugated nanosystem was developed to defeat myelosuppression and diarrhea induced by irinotecan.
Human bone marrow-derived mesenchymal stem cells (hBMSCs) are promising candidates for cell therapy in clinical trials. Applications of hBMSCs limited by cellular senescence due to long-term ex vivo expansion. Metformin, an oral hypoglycemic drug type 2 diabetes, has been shown have antiaging effects. However, the mechanisms metformin treatment remain controversial. Here, we used D-galactose (D-gal) establish appropriate model senescent explore effects metformin. Following with a low...
Breast cancer (BRCA) is the second most common malignancy in world and women. Here, we utilized publicly available BRCA dataset to investigate potential prognosis-related genes through integrated bioinformatics analysis.BRCA was obtained from Cancer Genome Atlas (TCGA) database. The ESTIMATE algorithm used calculate ImmuneScores StromalScores of samples then divided them into high- low-score groups based on median score. Common differentially expressed (DEGs) were identified differential...
The development of engineered or modified autologous stem cells is an effective strategy to improve the efficacy cell therapy. In this study, stemness and functionality adipose derived from type 1 diabetic donors (T1DM-ASC) were enhanced by treatment with Cu(II)-baicalein microflowers (Cu-MON). After Cu-MON, T1DM-ASC showed expression genes involved in cytokine-cytokine receptor interaction pathway increased cytokine secretion. Among top 13 differentially expressed between Cu-MON-treated...
Ferroptosis contributes to brain injury after germinal matrix hemorrhage (GMH). Mitochondrial ferritin (FTMT), a novel mitochondrial outer membrane protein, reduces oxidative stress in neurodegenerative diseases. In vitro, Deferiprone has been shown upregulate FTMT. However, the effects of FTMT upregulation by on neuronal ferroptosis GMH and its underlying mechanism not investigated. our study, 389 Sprague-Dawley rat pups postnatal day 7 were used establish collagenase-induced model an...
<bold>Ru1</bold> could most effectively inhibit tumor growth and avoid any detectable side-effects compared with other ruthenium(<sc>ii</sc>) complexes cisplatin, demonstrating its potential to be an exciting new drug candidate for glioblastoma treatment.
Takayasu arteritis (TA) is a chronic granulomatous vasculitis involving in the main branches of aorta. Previous studies mainly used peripheral blood and some vascular tissues but seldom have sequenced tissues. Here this study, we aimed to explore alterations mRNA TA by performing bulk RNA sequencing. A total 14 abdominal aortic including 8 from renal transplantation 6 patient with undergoing bypass surgeries. Bulk sequencing were performed after quality control, 1897 transcripts observed be...