A5100376530- Nanoplatforms for cancer theranostics
- Inflammatory mediators and NSAID effects
- Nanoparticle-Based Drug Delivery
- Mechanical Circulatory Support Devices
- Cardiac Structural Anomalies and Repair
- Pulmonary Hypertension Research and Treatments
- Ideological and Political Education
- HIV/AIDS Research and Interventions
- Estrogen and related hormone effects
- Photodynamic Therapy Research Studies
- HIV, Drug Use, Sexual Risk
- Immune Response and Inflammation
- Immune Cell Function and Interaction
- Immune cells in cancer
- Photoacoustic and Ultrasonic Imaging
- Cancer, Lipids, and Metabolism
- Pregnancy and preeclampsia studies
- Fluorine in Organic Chemistry
- Molecular Sensors and Ion Detection
- Hepatitis C virus research
- Transplantation: Methods and Outcomes
- Eicosanoids and Hypertension Pharmacology
- Immunotherapy and Immune Responses
- Educational Technology and Pedagogy
- MicroRNA in disease regulation
West China Hospital of Sichuan University
2003-2024
Center for Innovation
2023-2024
Columbia University
2014-2024
Nanjing Tech University
2024
Anhui Medical University
2010-2024
Columbia University Irving Medical Center
2023-2024
First Affiliated Hospital of Anhui Medical University
2018-2024
Tongji University
2018-2024
Shanghai Tenth People's Hospital
2023-2024
Sichuan University
2003-2024
Cancer immunotherapy has achieved promising clinical responses in recent years owing to the potential of controlling metastatic disease. However, there is a limited research prove superior therapeutic efficacy on breast cancer compared with melanoma and non-small-cell lung because its expression PD-L1, low infiltration cytotoxic T lymphocytes (CTLs), high level myeloid-derived suppressor cells (MDSCs). Herein, multifunctional nanoplatform (FA-CuS/DTX@PEI-PpIX-CpG nanocomposites, denoted as...
Abstract Glucose oxidase (GOx), which catalyzes the conversion of glucose into gluconic acid and hydrogen peroxide (H 2 O ) in presence oxygen (O ), has aroused growing interest for cancer therapy. GOx can starve tumor cells to death by depleting glucose, is very important their energy supply, generated H be used oxidation In addition, GOx‐catalyzed exerts a variety effects on environment, such as enhancing hypoxia increasing acidity. The full use these characteristics effectively reduce...
Abstract Given that traditional anticancer therapies fail to significantly improve the prognoses of triple negative breast cancer (TNBC), new modalities with high efficiency are urgently needed. Herein, by mixing metal‐phenolic network formed tannic acid (TA), bleomycin (BLM), and Fe 3+ glutathione peroxidase 4 (GPX4) inhibitor (ML210) loaded hollow mesoporous Prussian blue (HMPB) nanocubes, HMPB/ML210@TA‐BLM‐Fe (HMTBF) nanocomplex is prepared favor ferroptosis/apoptosis synergism in TNBC....
Hypertension, trouble sleeping and depression, as three major public health problems, were closely related. This study evaluated the independent association of depression with hypertension interaction effect between on in Americans. The data this cross-sectional was from 2005–2018 National Health Nutritional Examination Survey (NHANES) hypertension, confounding factor information. Multivariate logistic regression model subgroup analyses severity conducted to assess relationship hypertension....
Integrating chemodynamic therapy (CDT) and photodynamic (PDT) into one nanoplatform can produce much more reactive oxygen species (ROS) for tumor therapy. Nevertheless, it is still a great challenge to selectively generate sufficient ROS in regions. Meanwhile, CDT PDT are restricted by insufficient H2O2 content the as well limited tissue penetration of light source. In this study, smart pH/ROS-responsive nanoplatform, Fe2+@UCM-BBD, rationally designed combination The acidic microenvironment...
Coronavirus disease 2019 (COVID-19) is a global pandemic. Previous studies have reported dyslipidemia in patients with COVID-19. Herein, we conducted retrospective study and bioinformatics analysis to evaluate the essential data of lipid profile as well possible mechanism COVID-19.First all, included three cohorts: COVID-19, healthy population, chronic obstructive pulmonary (COPD). For each subject, serum profiles biochemical were compared, including triglycerides (TG), total cholesterol...
Copper is indispensable to organisms, while its homeostatic imbalance may interference normal cellular physiological processes and even induce cell death. Artificially regulating copper content provides a viable strategy activate antineoplastic effect. In light of this, ions homeostasis perturbator (CuP-CL) with cinnamaldehyde (Cin) packaging thermosensitive liposome coating reported. Following laser exposure, the doping Cu
We describe trends in characteristics and outcomes among adults initiating HIV care treatment Ethiopia from 2006-2011. conducted a retrospective longitudinal analysis of HIV-positive (≥15 years) enrolling at 56 Ethiopian health facilities 2006–2011. investigated over time the proportion through provider-initiated counseling testing (PITC), baseline CD4+ cell counts WHO stage. Additionally, we assessed (recorded death, loss to follow-up (LTF), transfer, total attrition death plus LTF)) before...
Background Antiretroviral therapy (ART) improves morbidity and mortality in patients with HIV, however high rates of loss to follow-up (LTF) have been documented HIV care treatment programs. Methods We analyzed routinely-collected data on HIV-infected ≥15 years enrolled at 41 healthcare facilities Rwanda from 2005 2010. LTF was defined as not attending clinic the last 12 months for pre-ART 6 ART patients. For period, sub-distribution hazards models were constructed estimate death account...
Cyclin D1 (CCND1) is frequently overexpressed in malignant gliomas. We have previously shown ectopic overexpression of CCND1 human gliomas cell lines.Quantitative reverse transcriptase PCR (qRT-PCR) and Western Blot (WB) was performed to investigate the expression glioma tissues lines. The biological function also investigated through knockdown BCYRN1 vitro.Here we reported that positively associated with pathological grade proliferative activity astrocytomas, as lowest found normal brain...
Although chronic erosive gastritis (CEG) is common, its clinical characteristics have not been fully elucidated. The lack of consensus regarding treatment has resulted in varied regimens.
Abstract Background Chemodynamic therapy (CDT), employing Fenton or Fenton-like catalysts to convert hydrogen peroxide (H 2 O ) into toxic hydroxyl radicals (·OH) kill cancer cells, holds great promise in tumor due its high selectivity. However, the therapeutic effect is significantly limited by insufficient intracellular H level cells. Fortunately, β-Lapachone (Lapa) that can exert -supplementing functionality under catalysis of nicotinamide adenine dinucleotide (phosphate) NAD(P)H: quinone...
A multifunctional tumor-targeting SN38-conjugated nanosystem was developed to defeat myelosuppression and diarrhea induced by irinotecan.