A5100461961- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Physiological and biochemical adaptations
- Circular RNAs in diseases
- Advanced biosensing and bioanalysis techniques
- Cancer, Hypoxia, and Metabolism
- High Altitude and Hypoxia
- Chemical Synthesis and Analysis
- Plant Molecular Biology Research
- interferon and immune responses
- Neurological Disease Mechanisms and Treatments
- TGF-β signaling in diseases
- RNA Interference and Gene Delivery
- Metal-Organic Frameworks: Synthesis and Applications
- Nanoparticle-Based Drug Delivery
- Magnetism in coordination complexes
- Bat Biology and Ecology Studies
- Essential Oils and Antimicrobial Activity
- Neuroinflammation and Neurodegeneration Mechanisms
- Aquaculture disease management and microbiota
- Hippo pathway signaling and YAP/TAZ
- Cellular transport and secretion
- Adipose Tissue and Metabolism
Shandong University
2021-2025
Second People's Hospital of Yunnan Province
2024
Yunnan University
2024
First Hospital of Shijiazhuang
2019-2024
Anhui Institute of Information Technology
2024
Lanzhou University
2022-2024
Lanzhou Institute of Husbandry and Pharmaceutical Sciences
2020-2024
Chinese Academy of Agricultural Sciences
2020-2024
Ministry of Agriculture and Rural Affairs
2020-2024
State Key Laboratory of Microbial Technology
2023-2024
Multitopic organic linkers can provide a means to organize metal cluster nodes in regular three-dimensional array. Herein, we show that isonicotinic acid N-oxide (HINO) serves as the linker formation of metal-organic framework featuring Dy2 single-molecule magnets nodes. Importantly, guest solvent exchange induces reversible single-crystal transformation between phases Dy2(INO)4(NO3)2⋅2 (solvent=DMF (Dy2-DMF), CH3CN (Dy2-CH3CN)), thereby switching effective magnetic relaxation barrier...
The study was designed to determine the role of long noncoding RNA (lncRNA), metastasis-associated lung adenocarcinoma transcript 1 (Malat1), in ischemic stroke outcome. Primary mouse brain microvascular endothelial cells (BMECs) were cultured and treated with Malat1 GapmeR before 16 h oxygen glucose depravation (OGD). Cell death assayed by LDH MTT methods. knock-out wild-type mice subjected middle cerebral artery occlusion (MCAO) 24–72 reperfusion. To explore underlying mechanism, apoptotic...
Abstract The suppression of types I and III interferon (IFN) responses by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) contributes to the pathogenesis disease 2019 (COVID‐19). strategy used SARS‐CoV‐2 evade antiviral immunity needs further investigation. Here, we reported that ORF9b inhibited IFN production targeting multiple molecules innate signaling pathways. impaired induction IFNs Sendai virus poly (I:C). activation induced components cytosolic dsRNA‐sensing pathways...
Nowadays, essential oils are recognized as safe substances and can be used antibacterial additives. Salvia sclarea is one of the most important aromatic plants cultivated world-wide a source oils. In addition to being flavoring foods, oil also act antimicrobials preservatives against food spoilage. Understanding more about performance possible mechanism will helpful for its application in future. But so far few related researches have been reported.In our study, showed obvious activity all...
Rationale: Angiogenesis promotes neurological recovery after stroke and is associated with longer survival of patients. Cerebral angiogenesis tightly controlled by certain microRNAs (miRs), such as the miR-15a/16-1 cluster, among others. However, function cluster in endothelium on postischemic cerebral not known. Objective: To investigate functional significance molecular mechanism endothelial ischemic brain. Methods Results: Endothelial cell-selective conditional knockout (EC-miR-15a/16-1...
Lethal giant larvae (Lgl) plays essential and conserved functions in regulating both cell polarity tumorigenesis Drosophila melanogaster vertebrates. It is well recognized that plasma membrane (PM) or cortex localization crucial for Lgl function vivo, but its membrane-targeting mechanisms remain poorly understood. Here, we discovered hypoxia acutely reversibly inhibits PM targeting through a posttranslational mechanism independent of the well-characterized atypical protein kinase C (aPKC)...
It is extremely difficult to develop targeted treatments for triple-negative breast (TNB) cancer, because these cells do not express any of the key biomarkers usually exploited this goal.In work, we a solution in form cascade responsive nanoplatform based on thermo-sensitive poly(N-vinylcaprolactam) (PNVCL)-chitosan (CS) nanoparticles (NPs). These are further modified with cell penetrating peptide (CPP) and loaded chemotherapeutic drug doxorubicin (DOX). The base copolymer was optimized...
A selective antimicrobial strategy based on triggering of pore-forming toxin, which is secreted by infective bacteria, was designed to fight <italic>Staphylococcus aureus</italic>.
Angiogenesis is a complex process that depends on the delicate regulation of gene expression. Dysregulation transcription during angiogenesis often leads to various human diseases. Emerging evidence has recently begun show long non-coding RNAs (lncRNAs) may mediate in both physiological and pathological conditions; concurrently, underlying molecular mechanisms are largely unexplored. Previously, our lab identified metastasis associates lung adenocarcinoma transcript 1 (Malat1) as an...
The blood-brain barrier (BBB) maintains a stable brain microenvironment. Breakdown of BBB integrity during cerebral ischemia initiates devastating cascade events that eventually leads to neuronal loss. MicroRNAs are small noncoding RNAs suppress protein expression, and we previously showed the miR-15a/16-1 cluster is involved in pathogenesis ischemic injury. Here, demonstrated when subjected experimentally induced stroke, mice with an endothelial cell (EC)-selective deletion had smaller...
Soybean residue is a by-product of soybean product production that wasted unreasonably at present. Accomplishing the efficient utilization can save resources. A composite microbial system was constructed using lactic acid bacteria (LAB) and Saccharomyces cerevisiae (SC), modified prepared by solid fermentation. In order to explore value as food raw material, its physical chemical properties, adsorption antioxidant properties were studied. The results showed soluble dietary fiber (SDF) yield...
Cyclic GMP-AMP synthase (cGAS) undergoes liquid-liquid phase separation (LLPS) to trigger downstream signaling upon double-stranded DNA (dsDNA) stimulation, and the condensed cGAS colocalizes with stress granules (SGs). However, molecular mechanism underlying modulation of activation by SGs remains elusive. In this study, we show that USP8 is localized dsDNA stimulation potentiates cGAS-stimulator interferon genes (STING) signaling. A inhibitor ameliorates pathological inflammation in...
The CXCL12-CXCR4 chemokine axis may play a very important role in ovarian cancer cells proliferation, migration, invasion, and peritoneal metastasis vitro vivo. In this study, transfected SKOV3-CXCR4, vector SKOV3-negative, nontransfected SKOV3 cells, human mesothelial (HPMCs) were cultivated vitro, the invasion of these investigated with or without influence axis. Nude mice models created by injection into cavity for investigation metastasis. Our results demonstrated that SKOV3-CXCR4 group,...
Over many years, extensive efforts have focused on the development and improvement of diagnostic therapeutic strategies to reduce stroke-associated neurovascular damage, such as blood-brain barrier dysfunction, brain edema, parenchymal inflammation, neural cell death. However, only clinically applied pharmacological therapy date for treatment acute ischemic stroke is thrombolysis. Because short window current thrombolytic activation various pathophysiological signaling cascades triggered...
MicroRNAs (MiRNAs) play important regulatory roles in many cellular processes. MiR-143 is highly enriched the mouse ovary, but its and underlying mechanisms are not well understood. In current study, we show that miR-143 located granulosa cells of primary, secondary antral follicles. To explore specific functions miR-143, transfected inhibitor into primary cultured to study loss function results showed silencing significantly increased estradiol production steroidogenesis-related gene...