A5015758150- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Genetic and Environmental Crop Studies
- MicroRNA in disease regulation
- Protein purification and stability
- RNA and protein synthesis mechanisms
- Monoclonal and Polyclonal Antibodies Research
- RNA Research and Splicing
- Agricultural pest management studies
- RNA modifications and cancer
- Legume Nitrogen Fixing Symbiosis
- vaccines and immunoinformatics approaches
Beijing Academy of Agricultural and Forestry Sciences
2024
Institute of Biophysics
2024
Chinese Academy of Sciences
2010-2024
University of Chinese Academy of Sciences
2024
Shanghai Institutes for Biological Sciences
2015
Abstract Pseudouridine, one of the most abundant RNA modifications, is synthesized by stand-alone or RNA-guided pseudouridine synthases. Here, we comprehensively mapped pseudouridines in rRNAs, tRNAs and small RNAs archaeon Sulfolobus islandicus identified Cbf5-associated H/ACA RNAs. Through genetic deletion vitro modification assays, determined responsible enzymes for these modifications. The pseudouridylation machinery S. consists aPus7 aPus10, six that account all pseudouridines. These...
As the potential of epitope chips for routine application in diagnostics relies on careful selection peptides, reliable mapping results are utmost interest to medical community. Mass spectrometric mapping, combination with peptide chip analysis, showed that autoantibodies from patients who suffered rheumatoid arthritis (RA) were directed against distinct surface structures full-length human autoantigen RA33 as well partial sequences. Using combined mass extraction and analysis approach, four...
Rice bean (Vigna umbellata), an underrated legume crop, demonstrates strong adaptability to poor soil fertility and has significant potential enhance global food security. It is valuable both as a vegetable fodder crop due its high protein content, essential fatty acids, micronutrients. Despite the sequencing of high-quality genome rice bean, mitochondrial (mitogenome) sequence not yet been reported. For first time, mitogenome was assembled annotated using PacBio HiFi Geseq software. The...