A5006568691- Systemic Lupus Erythematosus Research
- T-cell and B-cell Immunology
- SARS-CoV-2 and COVID-19 Research
- Pelvic floor disorders treatments
- Salivary Gland Disorders and Functions
- Diabetes and associated disorders
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Urological Disorders and Treatments
- COVID-19 Clinical Research Studies
- Bladder and Urothelial Cancer Treatments
- Liver Disease Diagnosis and Treatment
- Peripheral Neuropathies and Disorders
- Urinary Bladder and Prostate Research
- Hematopoietic Stem Cell Transplantation
- Cytokine Signaling Pathways and Interactions
- Breast Cancer Treatment Studies
- Multiple and Secondary Primary Cancers
- Inflammatory mediators and NSAID effects
- Pediatric Urology and Nephrology Studies
- Urinary and Genital Oncology Studies
- Ovarian cancer diagnosis and treatment
- Estrogen and related hormone effects
- Urologic and reproductive health conditions
- Hepatitis C virus research
Charité - Universitätsmedizin Berlin
2021-2025
Berlin Institute of Health at Charité - Universitätsmedizin Berlin
2021-2024
German Rheumatism Research Centre
2022-2024
Leibniz Association
2024
The University of Texas Health Science Center at San Antonio
2020-2023
National and Kapodistrian University of Athens
2022
Galapagos (Belgium)
2022
Janssen (Switzerland)
2022
Novartis (France)
2022
Pfizer (United Kingdom)
2022
Objective Patients with autoimmune inflammatory rheumatic diseases receiving rituximab (RTX) therapy are at higher risk of poor COVID‐19 outcomes and show substantially impaired humoral immune response to anti–SARS–CoV‐2 vaccine. However, the complex relationship between antigen‐specific B cells T level cell repopulation necessary achieve anti‐vaccine responses remain largely unknown. Methods Antibody SARS–CoV‐2 vaccines induction CD4/CD8 subsets were studied in 19 patients rheumatoid...
To constrain the properties of first stars with chemical abundance patterns observed in metal-poor stars, one must identify any non-trivial effects that hydrodynamics metal dispersal can imprint on abundances. We use realistic cosmological hydrodynamic simulations to quantify distribution metals resulting from Population III supernova and a small number such supernovae exploding close succession. Overall, ejecta are highly inhomogeneously dispersed throughout simulations. When bubbles...
The interferon pathway, a key antiviral defense mechanism, is being considered as therapeutic target in COVID-19. Both, substitution of and JAK/STAT inhibition to limit cytokine storms have been proposed. However, little known about possible abnormalities STAT signaling immune cells during SARS-CoV-2 infection. We investigated downstream targets signaling, including STAT1, STAT2, pSTAT1 2, IRF1, 7 9 by flow cytometry 30 patients with COVID-19, 17 mild, 13 severe report upregulation STAT1...
Abstract Bone marrow plasma cells (BMPC) are the correlate of humoral immunity, consistently releasing antibodies into bloodstream. It remains unclear if BMPC reflect different activation environments or maturation their precursors. Here we define human heterogeneity and track recruitment antibody-secreting (ASC) from SARS-CoV-2 vaccine immune reactions to bone (BM). Trajectories based on single-cell transcriptomes repertoires peripheral BM ASC reveal sequential colonisation compartments. In...
Objective Altered composition of the B cell compartment in pathogenesis systemic lupus erythematosus (SLE) is characterized by expanded plasmablast and IgD–CD27– double‐negative populations. Previous studies showed that cells represent a heterogeneous subset, further characterization needed. Methods We analyzed 2 independent cohorts healthy donors SLE patients, using combined approach flow cytometry (for 16 28 patients) mass 18 24 targeted RNA‐Seq analysis. To compare subset formation during...
Introduction The diagnosis of Sjögren’s disease (SjD) in patients without autoantibodies against Ro/SSA is a major challenge. We aimed to identify novel SjD that may facilitate the diagnostic procedure for negative SjD. Methods IgG and IgA autoantibody reactivity 94 potential candidate autoantigens SjD, selected from discovery screen 1,629 human antigens coupled Luminex beads prior knowledge about biological relevance, were examined serum (n=347) using ELISA technology. Healthy (HC, n=118)...
Abstract Objectives Patients with autoimmune inflammatory rheumatic diseases receiving rituximab (RTX) therapy show substantially impaired anti-SARS-CoV-2 vaccine humoral but partly inducible cellular immune responses. However, the complex relationship between antigen-specific B and T cells level of cell repopulation necessary to achieve anti-vaccine responses remain largely unknown. Methods Antibody SARS-CoV-2 vaccines induction CD4/CD8 subsets were studied in 19 rheumatoid arthritis (RA)...
No AccessJournal of Urology1 Feb 1938Pathological and Bacteriological Processes Present In Prostatitis Tissue Reaction to Therapy1 J. Sydney Ritter, Charles Lippow RitterJ. Ritter More articles by this author , LippowCharles View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)71842-3AboutPDF ToolsAdd favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail © 1938 The American Urological Association Education Research,...
Autoreactive B cells and interferon (IFN) signature are hallmarks of primary sjögren's syndrome (pSS), but how IFN signaling pathways influence autoantibody production clinical manifestations remain unclear. More detailed studies hold promise for improved diagnostic methodologies personalized treatment.
Antibody-secreting cells (ASCs) contribute to immunity through production of antibodies and cytokines. Identification specific markers ASC would allow selective targeting these in several disease contexts. Here, we performed an unbiased, large-scale protein screening, identified twelve new molecules that are specifically expressed by murine ASCs. Expression markers, particularly CD39, CD81, CD130, CD326, is stable offers improved resolution for identification. We accessed their expression...
Abstract Background: Pathological complete response (pCR) is accepted by FDA as a surrogate endpoint for accelerated approval of targeted agents in combination with chemotherapy based on better long-term outcomes compared to residual disease (Cortazar 2014). Methods: The multi-center, adaptively-randomized I-SPY2 platform trial uses pCR the primary identify investigational that will improve women stage 2/3 breast cancer high risk early recurrence, across all signatures, hormone receptor...
Vaccination is considered as most efficient strategy in controlling SARS-CoV-2 pandemic spread. Nevertheless, patients with autoimmune inflammatory rheumatic diseases receiving rituximab (RTX) are at increased risk to fail humoral and cellular responses upon vaccination. The ability predict vaccination essential guide adequate safety optimal protection these patients.B- T- cell data before were evaluated for characteristics predicting vaccine altogether 15 RTX. Eleven rheumatoid arthritis...
No AccessJournal of Urology1 Mar 1949Physiological Principles Governing Therapy the Neurogenic Bladder J. Sydney Ritter and Andrew Sporer RitterJ. More articles by this author SporerAndrew View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)69103-1AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail © 1949 The American Urological Association Education Research, Inc.FiguresReferencesRelatedDetailsCited byBARTOLIN Z,...
No AccessJournal of Urology1 Jan 1950The Hypoplastic Kidney and the Atrophic Pyelonephritic Kidney1 J. Sydney Ritter Samuel E. Kramer RitterJ. More articles by this author KramerSamuel View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)68731-7AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail © 1950 The American Urological Association Education Research, Inc.FiguresReferencesRelatedDetailsCited Cieśliński S...
<title>Abstract</title> Bone marrow plasma cells (BMPC) emerge as a consequence of immune reactions and are considered the source antibodies that protect against recurrent infectious diseases throughout life. Despite their importance, it remains unclear if these reflect different activation environments or differentiation/maturation stages precursors. Here we track recruitment cells, generated in primary secondary to SARS-CoV-2 spike protein vaccines, human bone marrow. Trajectories based on...
No AccessJournal of Urology1 Nov 1957Colored Motion Picture Photography and Black-and-White Television the Human Urinary Bladder Other Interior Body Organs J.F. McCarthy, J. Sydney Ritter McCarthyJ.F. McCarthy More articles by this author , RitterJ. View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)66490-5AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail © 1957 The American Urological Association Education...
No AccessJournal of Urology1 Apr 1952Solusponge as a Hemostatic Agent in Urology J. Sydney Ritter and Henry Bloomberg RitterJ. BloombergHenry View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)68386-1AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "Solusponge Urology." The Journal Urology, 67(4), pp. 543–544 © 1952 by American Urological Association Education Research, Inc.FiguresReferencesRelatedDetailsCited...
Objective To assess the implication of hepatitis C virus (HCV) infection in development autoimmune thyroid response, autoantibodies were studied serum HCV positive patients. Methods Anti-microsomal, anti-thyroperoxidase (anti-TPO) and anti-thyroglobulin antibodies evaluated sera 100 patients with chronic (53 women 47 men; mean age = 55±5 years). In parallel, investigated blood samples obtained from two separated control groups: age-matched negative-HBV (25 women, 25 age= 47±6 years) healthy...
No AccessJournal of Urology1 Jan 1955Aortography J. Sydney Ritter RitterJ. More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)67379-8AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail © 1955 The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited ByWoodruff J, Chalek C, Ottoman R Wilk S (2018) Roentgen Diagnosis Renal NeoplasmsJournal...
Background Durable vaccine-mediated immunity relies on the generation of long-lived plasma cells and memory B (MBCs), differentiating upon germinal center (GC) reactions. SARS-CoV-2 mRNA vaccination induces a strong GC response in healthy volunteers (HC), but limited data is available about longevity rituximab treatment. Methods We evaluated humoral cellular responses 3rd seven patients with rheumatoid arthritis (RA) who initially mounted anti-spike IgG antibodies after primary 2x got...