A5057927715- SARS-CoV-2 and COVID-19 Research
- Gut microbiota and health
- COVID-19 Clinical Research Studies
- Clostridium difficile and Clostridium perfringens research
- Hematopoietic Stem Cell Transplantation
- vaccines and immunoinformatics approaches
- Gastrointestinal motility and disorders
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Probiotics and Fermented Foods
- Bacterial Infections and Vaccines
- Monoclonal and Polyclonal Antibodies Research
- Healthcare Systems and Public Health
- Microscopic Colitis
- Alcohol Consumption and Health Effects
- Whipple's Disease and Interleukins
- Diabetes and associated disorders
- Kawasaki Disease and Coronary Complications
- Tryptophan and brain disorders
- Helicobacter pylori-related gastroenterology studies
- Peripheral Neuropathies and Disorders
- Inflammatory Bowel Disease
- IL-33, ST2, and ILC Pathways
- Salivary Gland Disorders and Functions
- Immunotherapy and Immune Responses
Leibniz Association
2021-2025
German Rheumatism Research Centre
2021-2024
Lomonosov Moscow State University
2017-2023
Moscow State University
2021
Background Alcohol-associated liver disease (ALD) is an important cause of morbidity and mortality worldwide. The intestinal microbiota involved in the development progression ALD; however, little known about commensal fungi therein. Methods We studied dynamic changes fungal microbiome, or mycobiome, 66 patients with alcohol use disorder (AUD) after 2 weeks abstinence using internal transcribed spacer (ITS2) amplicon sequencing fecal samples. Results Patients AUD had significantly increased...
In a subset of children and adolescents, SARS-CoV-2 infection induces severe acute hyperinflammatory shock1 termed multisystem inflammatory syndrome in (MIS-C) at four to eight weeks after infection. MIS-C is characterized by specific T cell expansion2 systemic hyperinflammation3. The pathogenesis remains largely unknown. Here we show that impaired reactivation virus-reactive memory cells, which depends on increased serum levels the cytokine TGFβ resembling those occur during COVID-19 (refs....
Abstract Bone marrow plasma cells (BMPC) are the correlate of humoral immunity, consistently releasing antibodies into bloodstream. It remains unclear if BMPC reflect different activation environments or maturation their precursors. Here we define human heterogeneity and track recruitment antibody-secreting (ASC) from SARS-CoV-2 vaccine immune reactions to bone (BM). Trajectories based on single-cell transcriptomes repertoires peripheral BM ASC reveal sequential colonisation compartments. In...
Akkermansia muciniphila is a gram-negative anaerobic bacterium, which represents part of the commensal human microbiota. Decline in abundance A. among other microbial species gut correlates with severe systemic diseases such as diabetes, obesity, intestinal inflammation and colorectal cancer. Due to its mucin-reducing immunomodulatory properties, use probiotics containing sp. appears promising approach treatment metabolic inflammatory diseases. In particular, number studies have focused on...
The intestinal tract is densely populated by microbiota consisting of various commensal microorganisms that are instrumental for the healthy state living organism. Such commensals generate molecules can be recognized Toll-like receptors immune system leading to inflammation marked strong upregulation proinflammatory cytokines, such as TNF, IL-6, and IL-1β. To prevent excessive inflammation, a single layer constantly renewing, highly proliferating epithelial cells (IEC) provides proper...
Successful treatment of chronic inflammatory diseases integrates both the cessation inflammation and induction adequate tissue repair processes. Strikingly, targeting a single proinflammatory cytokine, tumor necrosis factor (TNF), induces processes in relevant cohort bowel disease (IBD) patients. However, molecular mechanisms underlying intestinal following TNF blockade during IBD remain elusive. Using novel humanized model experimental colitis, we demonstrate that interfered with program...
The commensal microflora provides a repertoire of antigens that illicit mucosal antibodies. In some cases, these antibodies can cross-react with host proteins, inducing autoimmunity, or other microbial antigens. We demonstrate the oral microbiota induce salivary anti-SARS-CoV-2 Spike IgG via molecular mimicry. Anti-Spike in saliva correlated enhanced abundance Streptococcus salivarius 1 month after vaccination. Several human bacteria, including S. salivarius, were recognized by...
<title>Abstract</title> Bone marrow plasma cells (BMPC) emerge as a consequence of immune reactions and are considered the source antibodies that protect against recurrent infectious diseases throughout life. Despite their importance, it remains unclear if these reflect different activation environments or differentiation/maturation stages precursors. Here we track recruitment cells, generated in primary secondary to SARS-CoV-2 spike protein vaccines, human bone marrow. Trajectories based on...
Abstract The commensal microflora is a source for multiple antigens that may induce cross-reactive antibodies against host proteins and pathogens. However, whether bacteria can SARS-CoV-2 remains unknown. Here we report several contribute to the generation of IgA receptor-binding domain (RBD) Spike protein. We identified unexposed individuals with RBD-binding at their mucosal surfaces. Conversely, neutralising monoclonal anti-RBD recognised distinct bacterial species. Some these bacteria,...
COVID-19 is a systemic inflammatory disease initiated by SARS-CoV-2 virus infection. Multiple vaccines against the Wuhan variant of have been developed including whole virion beta-propiolactone-inactivated vaccine based on B.1.1 strain (CoviVac). Since most population has vaccinated targeting original or early variants SARS-CoV-2, emergence novel mutant raises concern over possible evasion vaccine-induced immune responses. Here, we report mechanism protection CoviVac, virion-based vaccine,...
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The article highlights the problems associated with high prevalence of cardiovascular diseases (CVD) and their adverse impacts, one which is acute coronary syndrome (ACS). problem relevance reflected in economic damage due to premature mortality working age, as well population disability ACS. Severe effects CVD are particularly explained by failure patients take antiplatelet drugs reduce both risk recurrent disease, including occurrence ACS, overall mortality. study pharmaceutical market...
Intestinal microbiota controls multiple aspects of body homeostasis. The composition changes easily in response to internal or external factors, which may result dysbiosis and associated inflammatory reactions. Thus, maintaining the by host immune system is crucial, one main mechanisms for control production immunoglobulin A (IgA) at mucosal surfaces. molecular regulating interactions between remain obscure. panel hybridoma cell lines was constructed produce monoclonal IgA antibodies...