A5070710980- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Diet, Metabolism, and Disease
- Blood Pressure and Hypertension Studies
- HIV-related health complications and treatments
- Liver Diseases and Immunity
- Hepatitis B Virus Studies
- Diet and metabolism studies
- Hepatitis C virus research
- Gut microbiota and health
- Colorectal Cancer Screening and Detection
- Pancreatic and Hepatic Oncology Research
- Hormonal Regulation and Hypertension
- Liver physiology and pathology
- Gastric Cancer Management and Outcomes
- Gastrointestinal motility and disorders
- Gallbladder and Bile Duct Disorders
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Helicobacter pylori-related gastroenterology studies
- Alcohol Consumption and Health Effects
- Renin-Angiotensin System Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Health and Medical Studies
- Gastrointestinal disorders and treatments
- Pancreatitis Pathology and Treatment
University of Cologne
2016-2025
University Hospital Cologne
2016-2025
Poliklinik für Endokrinologie, Diabetologie und Präventivmedizin
2015-2024
Constructing Excellence
2016
Lighthouse Trust
2016
Heidelberg University
1974-2016
University Hospital Heidelberg
1974-2016
German Center for Infection Research
2016
Sociedad Hispano Mundial
2015
Centrum für Integrierte Onkologie
2007-2015
The anti-asthmatic effects of theophylline may supplement those inhaled steroids in asthma. aim the present trial was to study how addition compares doubling dose steroid asthmatics who remain symptomatic on beclomethasone dipropionate (BDP) 400 microg x day(-1). designed as a randomized, double-blind, parallel-group several European countries. Sixty nine patients were treated for 6 weeks with plus BDP day(-1), compared 64 800 micro mean+/-SD serum concentration 10.1+/-4.2 mg L(-1). Lung...
Chronic infection with hepatitis C virus (HCV) is one of the main causes hepatocellular carcinoma. However, molecular mechanisms linking to cancer development remain poorly understood. Here we used HCV-infected cells and liver biopsies study how HCV modulates glutaminolysis pathway, which known play an important role in cellular energetics, stress defense, neoplastic transformation. Transcript levels glutaminolytic factors were quantified Huh7.5 or primary human hepatocytes infected Japanese...
The binding of thiátmine pyrophosphate to apotransketolase from baker's yeast has been studied by measuring the cofactor‐dependent activity after passage through a column Sephadex G‐25 or dialysis, respectively. At pH values >6.5, cofactors Mg 2+ and thiamine were lost upon gel filtration indicating reversible binding. Thiamine alone was able activate partially reconstitute transketolase in absence divalent cations. Using fluorescence‐quenching measurements reconstitution process as...
<h3>Objective</h3> Inflammation and oxidative stress drive disease progression in chronic hepatitis C (CHC) towards hepatocellular carcinoma. HCV is known to increase intracellular levels of reactive oxygen species (ROS), but how it eliminates ROS less well known. The role the scavenger glutathione peroxidase 4 (GPx4), induced by HCV, viral life cycle was analysed. <h3>Design</h3> study performed using a replicative vitro infection model liver biopsies derived from two different CHC patient...
Background&Aims: Metabolic dysfunction-associated steatotic liver disease (MASLD) is an independent risk factor for cardiovascular morbidity and mortality. Another critical in these patients arterial hypertension (AH). Although it estimated that 50% of MASLD are suffering from AH, 24-h ambulatory blood pressure monitoring (24-h-ABPM), the gold standard diagnosing hypertension, often neglected. However, only 24-h-ABPM can identify subtypes, particularly nocturnal (NH), which a stronger...
Because several groups have recently questioned a mediating role for cyclic AMP in adrenocortical steroidogenesis, we analysed the problem more detail by measuring three different pools cells isolated from decapsulated rat adrenals. Extra-cellular, total intracellular and bound were determined radioimmunoassay comparison with corticosterone production induced low corticotropin concentrations. The increase extracellular concentrations was dependent on presence of phosphodiesterase inhibitor...
Aberrant activation of plasmacytoid dendritic cells (pDCs) with excessive production interferon alpha (IFNα) represents one the hallmarks immune during chronic phase human immunodeficiency virus (HIV) infection. A number studies have shown that disruption mucosal integrity in gut is a cause persistent activation. However, little known about role pDCs play this process, and our current understanding comes from simian macaque model. Thus, present study we sought to investigate frequency...
Overconsumption of carbohydrates and lipids are well known to cause nonalcoholic fatty liver disease (NAFLD), while the role nutritional protein intake is less clear. In Western diet, meat other animal products main source, with varying concentrations specific amino acids. Whether amount or composition associated a higher risk for severity has not yet been examined. this study, we investigated associations dietary components histological activity by analyzing detailed 14‐day food records in...
Abstract Background and Aim Several studies observed alterations in the gut microbiota patients with non‐alcoholic fatty liver disease (NAFLD). However, analyzed patient populations methods strongly differ among these studies. The aim of this study was to prove reproducibility published results provide a detailed overview all findings our NAFLD cohort using next generation sequencing methods. Methods individual taxonomic composition fecal samples from 90 21 healthy controls 16S rRNA gene...
Aims To develop, validate and compare a non-invasive fibrosis scoring system for non-alcoholic fatty liver disease (NAFLD) derived from routinely obtained clinical biochemical parameters. Methods 267 consecutive patients with biopsy proven or steatohepatitis were randomly assigned to the estimation (2/3) validation (1/3) group develop model prediction of advanced fibrosis. Univariate statistics performed without fibrosis, following multivariate logistic regression analysis new was...
Treatment of renal anemia with rhEPO (120 U/kg body weight/hemodialysis) in transfusion-dependent patients on maintenance hemodialysis led to an increase blood pressure, regional peripheral resistance and whole viscosity. Our results are agreement earlier findings that partial correction hemodynamic changes characterized by a fall cardiac output together pressure due increased vascular resistance. The viscosity correlated the but not mean arterial pressure. Thus, other regulating factors...