A5009108182- Liver Disease Diagnosis and Treatment
- Liver physiology and pathology
- Parasites and Host Interactions
- Protease and Inhibitor Mechanisms
- Peptidase Inhibition and Analysis
- Diet, Metabolism, and Disease
- Hepatitis B Virus Studies
- Drug Transport and Resistance Mechanisms
- Liver Disease and Transplantation
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Liver Diseases and Immunity
- Diet and metabolism studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Cystic Fibrosis Research Advances
- Endoplasmic Reticulum Stress and Disease
- Pediatric Hepatobiliary Diseases and Treatments
- Cytokine Signaling Pathways and Interactions
- Signaling Pathways in Disease
- Hepatitis C virus research
- Cell Adhesion Molecules Research
- Helicobacter pylori-related gastroenterology studies
- Inflammatory Bowel Disease
- Digestive system and related health
- Mycobacterium research and diagnosis
- Drug-Induced Hepatotoxicity and Protection
Justus-Liebig-Universität Gießen
2016-2025
Universitätsklinikum Gießen und Marburg
2012-2025
Giessen School of Theology
2010-2021
Universitätsklinikum Aachen
1999-2015
Kerckhoff Klinik
2010
Sankt-Antonius-Hospital Eschweiler
2009
Janssen (Germany)
2009
RWTH Aachen University
1996-2008
Deutsche Forschungsgemeinschaft
2005
University of Regensburg
2005
Bei diesem Dokument handelt es sich um die aktualisierte Fassung der 2006 erstmals erstellten S3-Leitlinie zum exokrinen Pankreaskarzinom.
Interleukin-6 (IL-6), leukemia inhibitory factor, oncostatin M, IL-11, and ciliary neurotropic factor are a family of cytokines neuronal differentiation factors which bind to composite plasma membrane receptors sharing the signal transducing subunit gp130. We have shown recently that IL-6 rapidly activate latent cytoplasmic transcription acute-phase response (APRF), by tyrosine phosphorylation, then binds elements various target genes. Here we demonstrate APRF is activated all acting through...
Abkürzungsverzeichnis AASLD: American Association for the Study of Liver Diseases AFP: Alpha-Fetoprotein ALD: Alcoholic Diesease ALT: Alaninaminotransferase APASL: Asian Pacific APRI: AST/platelet ratio ASH: Steatohepatitis ATI: Attenuation Imaging AUC: Area Under Curve AUROC: Receiver Operating Characteristic BMI: Body Mass Index CAP: Controlled Parameter CDT: Carbohydrate-Deficient Transferrin CT: Computertomographie DECT: Dual-Energy CT DPP4: Dipeptidyl Peptidase 4 EASL : European ELF:...
Tissue inhibitor of metalloproteinases-1 (TIMP-1) plays a crucial role in the pathogenesis hepatic fibrosis and thus may represent an important therapeutic target design anti-fibrotic strategies for chronic liver disease. We present innovative therapy based on assignment inactivated enzymes acting as scavengers TIMP-1. Hepatic was induced BALB/c mice by repetitive intraperitoneal CCl4 injection. The animals were treated with proteolytic inactive matrix metalloproteinase-9 mutants (E402Q,...
The purpose of this study was to investigate the costs and health status outcomes intensive care unit (ICU) admission in patients who present after sudden cardiac arrest with in-hospital or out-of-hospital cardiopulmonary resuscitation. Five-year survival, health-related quality life (Medical Outcome Survey Short Form-36 questionnaire, SF-36), ICU costs, hospital post-hospital per survivor, year gained, quality-adjusted gained admitted a single were assessed. One hundred ten 354 (31%) alive...
E-1 HintergrundDie Zöliakie ist eine lebenslange immunologisch vermittelte chronisch-entzündliche Darmerkrankung, die sich bei Personen mit genetisch-determiniertem Risiko manifestiert.Sie Folge einer fehlgerichteten Immunantwort auf Gluten und verwandte Proteine, in Weizen, Roggen, Gerste anderen Getreidesorten vorkommen.Die Immunreaktionen führen zu entzündlichen Veränderungen im Dünndarm potenziell systemischen Komplikationen.Die intestinale Schädigung wiederum kann Malabsorption von...
Matrix metalloproteinases (MMPs) are responsible for the turnover and degradation of extracellular matrix. They play a crucial role in growth migration colorectal carcinoma cells. Colorectal carcinomas characterized by enhanced expression MMP-2, MMP-9, MMP-7, MMP-13. The aim this study was to determine levels MMP-13, MMP-14 their specific inhibitor TIMP-1 inflammatory bowel diseases precancerous lesions colon, i.e., Crohn's disease ulcerative colitis, adenomatous polyps (APs) comparison....
Bone marrow (BM)-derived stem cells and CD34+ fibrocytes are associated with fibrogenesis in several organs. In an Abcb4 −/− mouse model for sclerosing cholangitis alpha-smooth muscle actin-positive (α-SMA+) myofibroblasts thought to play a pivotal role hepatic fibrogenesis. The aim of this study was 2-fold: (1) demonstrate that the origin important fibrogenetic cell population is BM; (2) investigate whether transplantation BM (BM-Tx) affects liver function, staging, grading. Surrogate...
Clinical data have provided evidence that schistosomiasis can promote hepatocellular carcinogenesis. c‐Jun and STAT3 are critical regulators of liver cancer development progression. The aim the present study was to investigate activation by Schistosoma mansoni infection. Expression function as well proliferation DNA repair were analyzed western blotting, electrophoretic mobility‐shift assay, immunohistochemistry in S. –infected hamsters, Huh7 cells, primary hepatocytes, human biopsies....
Hepatocyte growth factor (HGF) gene transfer inhibits liver fibrosis by regulating aberrant cellular functions, while mutant matrix metalloproteinase-9 (mMMP-9) enhances degradation neutralizing the elevated tissue inhibitor of metalloproteinase-1 (TIMP-1). It was shown that ASH1 and EZH2 methyltransferases are involved in development fibrosis; however, their role resolution phase has not been investigated. This study evaluated two mechanistically different therapeutic modalities, HGF mMMP-9...
Matrix metalloproteinases (MMPs) are involved in the remodeling processes of extracellular matrix and basement membrane. Most MMPs composed a regulatory, catalytic, hemopexin subunit. In many tumors expression MMP-9 correlates with local tumor growth, invasion, metastasis. To analyze role domain these processes, (MMP-9-PEX) was expressed as glutathione S-transferase fusion protein Escherichia coli. After proteolytic cleavage, isolated PEX purified by size exclusion chromatography. zymography...
The steady-state levels of extracellular matrix proteins are regulated by the rates their synthesis and degradation. Metalloproteinases specific inhibitors, tissue inhibitor metalloproteinases-1 -2 believed to play a crucial role in protein Here we show that is expressed rat hepatocytes primary culture inflammatory cytokines. Rat constitutively express mRNA inhibitors at low level. Incubation with conditioned medium from lipopolysaccharide-stimulated human monocytes led dramatic induction...
During inflammatory states, hepatocytes are induced to synthesize and secrete a group proteins called acute‐phase proteins. It has recently been shown that besides interleukin‐6 (IL‐6) related cytokines such as leukemia inhibitory factor, oncostation M interleukin‐11 also mediators of the degatic response. All these belong dematoqaietic family α‐helical cytokines. Here we show an additional member this cytokine family, ciliary neurotrophic factor (CNTF), induces hepatic protein genes...
Abstract Expression patterns of matrix metalloproteinase-9 (MMP-9) and its specific inhibitor, tissue inhibitor metalloproteinases-1 (TIMP-1), are closely correlated with physiological pathological processes characterized by the degradation accumulation extracellular (ECM). Both, activated MMP-9 pro-MMP-9 can bind to TIMP-1, most cell types secrete in complex TIMP-1. Utilizing immunofluorescence, we observed intracellular co-localization TIMP-1 stimulated human fibrosarcoma cells. In present...