A5028880988- Liver Disease Diagnosis and Treatment
- Liver physiology and pathology
- Signaling Pathways in Disease
- Lipid metabolism and biosynthesis
- Insect Resistance and Genetics
- Pancreatic function and diabetes
- Liver Diseases and Immunity
- Research in Cotton Cultivation
- Drug-Induced Hepatotoxicity and Protection
- Cannabis and Cannabinoid Research
- Toxin Mechanisms and Immunotoxins
- Bacteriophages and microbial interactions
- Hepatitis C virus research
- Parasites and Host Interactions
- Hepatitis B Virus Studies
- Salmonella and Campylobacter epidemiology
- Biochemical and Structural Characterization
- Pediatric Hepatobiliary Diseases and Treatments
- Enzyme Production and Characterization
- RNA Interference and Gene Delivery
- Cancer, Lipids, and Metabolism
- Alkaline Phosphatase Research Studies
- Cholesterol and Lipid Metabolism
- Drug Transport and Resistance Mechanisms
- Vibrio bacteria research studies
Indian Veterinary Research Institute
2014-2024
Justus-Liebig-Universität Gießen
2018-2021
Giessen School of Theology
2021
Indian Institute of Science Education and Research, Bhopal
2021
Institute of Engineering
2021
Sam Higginbottom Institute of Agriculture
2021
Biological E (India)
2014
Clinical data have provided evidence that schistosomiasis can promote hepatocellular carcinogenesis. c‐Jun and STAT3 are critical regulators of liver cancer development progression. The aim the present study was to investigate activation by Schistosoma mansoni infection. Expression function as well proliferation DNA repair were analyzed western blotting, electrophoretic mobility‐shift assay, immunohistochemistry in S. –infected hamsters, Huh7 cells, primary hepatocytes, human biopsies....
The endocannabinoid (EC) system has been implicated in the pathogenesis of several metabolic diseases, including nonalcoholic fatty liver disease (NAFLD). With current study we aimed to verify modulatory effect receptor 1 (CB1)-signaling on perilipin 2 (PLIN2)-mediated lipophagy. Here, demonstrate that a global knockout cannabinoid gene (CB1−/−) reduced expression lipid droplet binding protein PLIN2 livers CB1−/− and hepatitis B surface (HBs)-transgenic mice, which spontaneously develop...
Alpha-synucleinopathies, characterized by extracellular alpha-synuclein (αSyn or SNCA) accumulation and aggregation, have been linked to neurological disorders including Parkinson’s disease multiple system atrophy. P2RX7 is a non-selective cationic transmembrane purinergic receptor activated elevated levels of ATP, which typically occurs during inflammatory conditions. Activation αSyn implicated in neuronal degeneration, potentially causing pore dilation increased inflammation. By...
Cholesterol in lipid raft plays crucial role on cancer cell survival during metastasis of cells. Cancer cells are reported to enrich cholesterol which make them more susceptible death after depletion than normal Methyl-β-cyclodextrin (MβCD), an amphipathic polysaccharide known deplete the membrane cholesterol, induces selectively Present work was designed identify major form programmed depleted (MDA-MB 231 and 4T1) its impact migration efficiency Membrane alteration morphological changes 4T1...
Clinical studies demonstrated that nonalcoholic steatohepatitis is associated with liver-related outcomes in chronic hepatitis B. Furthermore, primary biliary fibrosis and atresia occurred patients HBV infection. Interestingly, B virus surface protein (HBs) transgenic mice spontaneously develop hepatic steatosis. Our aim to investigate the effect of Abcb4 knockout-induced cholestasis on liver steatosis HBs mice. Hybrids Abcb4-/- were bred BALB/c genetic background. Lipid synthesis, storage,...
Bone marrow-derived fibrocytes (FC) represent a unique cell type, sharing features of both mesenchymal and hematopoietic cells. FC were shown to specifically infiltrate the injured liver participate in fibrogenesis. Moreover, exert variety paracrine functions, thus possibly influencing disease progression. However, overall contribution fibrosis remains unclear. We aimed study effect specific depletion, utilizing herpes simplex virus thymidine kinase (HSV-TK)/Valganciclovir suicide gene...
Abstract Schistosomiasis (bilharzia) is a neglected tropical disease caused by parasitic flatworms of the genus Schistosoma , with considerable morbidity in parts Middle East, South America, Southeast Asia, sub-Saharan Africa, and particularly also Europe. The WHO describes an increasing global health burden more than 290 million people threatened potential to spread into regions temperate climates like Corsica, France. aim our study was investigate influence S. mansoni infection on...
This study was aimed to isolate and characterize bacteriophage against drug-resistant, shigatoxigenic Escherichia coli (STEC), one of the zoonotic, food-borne organisms associated with ruminants, mainly cattle. STEC were isolated (n = 35) from neonatal calves, dairy workers, surrounding environment their antimicrobial resistance pattern studied. Out 35 isolates tested, 17 found be multidrug resistant important antibiotics like ampicillin, amoxicillin-clavulanate, ciprofloxacin, streptomycin,...
Salmonellosis is considered as one of the widest spread foodborne zoonosis in industrialized well developing countries. It most frequently found gastrointestinal tracts animals and has been commonly associated with foods such raw meat, poultry, eggs dairy products. Poultry poultry products are supposed to make up fifty percent total vehicle transmission salmonella. In this study, we reported cloning sequence analysis cyclophilin gene (ppiB) from Salmonella Typhimurium. The resultant PCR...
Background: Peptidyl-prolyl cis-trans isomerase (PPIases) enzyme plays a vital role in protein folding. It catalyses the isomerisation of peptide bonds, an essential step for newly synthesized to acquire its correct functional conformation both prokaryotes and eukaryotes. Objective: The present study showed biochemical molecular characterisation cyclophilins (PpiB), type peptidyl-prolyl isomerases proteins from pathogenic bacteria Salmonella Typhimurium. Methods: Typhimurium is one leading...
To compare the efficacy between saponin adjuvanted paratuberculosis killed vaccine and Freund's incomplete (FIC) in mice model.
A histopathological hallmark of chronic hepatitis B virus (HBV) infection is the presence ground glass hepatocytes (GGHs). GGHs are liver cells that exhibit eosinophilic, granular, glassy cytoplasm in light microscopy and characterized by accumulation HBV surface (HBs) proteins endoplasmic reticulum (ER). More important, have been accepted as a precursor HCC may represent preneoplastic lesions liver. Here we show reason for phenotype patients with (CHB) HBs transgenic mice complex formation...
Transgene Mäuse, die großen Hüllproteine (HBs) des Hepatitis B Virus (HBV) exprimieren, entwickeln neben einer Leberfibrose nach etwa einem Jahr ein hepatozelluläres Karzinom (HCC). Der Endocannabinoidrezeptor 1 (CB1) ist maßgeblich an der Kontrolle chronischer Entzündungsprozesse in Leber beteiligt. Mit dem vorliegenden Projekt soll Einfluss und eine therapeutische Wirkung Cannabinoid Rezeptor 1-Knockouts (CB1 Knockout) auf den Lipidmetabolismus HBV-transgenen Mäusen untersucht werden.
Chronic hepatitis B infection is serious global health problem. Experimental investigations have suggested that HBV a potential trigger of liver steatosis. Interferon regulatory factors (IRFs) are transcription involved in innate immunity but also having role metabolism. IRF3 and IRF7 considered master regulators type I interferon (IFN) IFN stimulated gene (ISG) expression, which induced HBs transgenic mice. However, little known about the signaling metabolic diseases. Our present aim to...
The endocannabinoid (EC) system has been implicated in the pathogenesis of several metabolic diseases, including nonalcoholic fatty liver diseases (NAFLD). present study aims to describe effect global CB1 knockout on hepatic lipid metabolism a HBs transgenic mouse model.
Bone marrow-derived fibrocytes represent a unique cell type, sharing features of both mesenchymal and hematopoietic cells. They comprise ˜0.5% peripheral blood leucocytes have been implicated in fibrotic diseases the kidney, lung, heart, liver. Fibrocytes were shown to specifically infiltrate injured liver participate deposition extracellular matrix components. Moreover, hold potential regulate fibrogenesis via secretion TGF-β, MMPs, TNF-α, IL-1β, other inflammatory cytokines. Their...
ATP-binding cassette subfamily B member 4 (ABCB4) is a phospholipid translocator present at the canalicular membrane of hepatocytes, which "flops" phosphatidylcholine into bile. Abcb4-/- mice represent most reproducible in vivo model to study chronic cholestatic liver diseases. exhibit dysregulated lipid metabolism associated with disease pathogenesis. Hepatitis transgenic (HBs) spontaneously develop hepatic steatosis. We previously reported that virus surface proteins accelerate injury and...