A5008623785- Liver Disease Diagnosis and Treatment
- Parasites and Host Interactions
- Bladder and Urothelial Cancer Treatments
- Liver physiology and pathology
- Drug-Induced Hepatotoxicity and Protection
- Parasite Biology and Host Interactions
- Helminth infection and control
- Urinary and Genital Oncology Studies
- Organ Transplantation Techniques and Outcomes
- Hepatitis C virus research
- Cancer Research and Treatments
- Gut microbiota and health
- Genetic factors in colorectal cancer
- Epigenetics and DNA Methylation
- Pancreatitis Pathology and Treatment
- Cancer Cells and Metastasis
- Amoebic Infections and Treatments
- Mesenchymal stem cell research
- Diet, Metabolism, and Disease
- Pancreatic and Hepatic Oncology Research
- Nanoparticles: synthesis and applications
- Immune cells in cancer
- Cancer, Hypoxia, and Metabolism
- Pancreatic function and diabetes
- Genomics, phytochemicals, and oxidative stress
Theodor Bilharz Research Institute
2016-2025
IBM (Egypt)
2019
National Institute of Pathology
2018
Cairo University
2007-2016
Children Cancer Hospital
2016
Stanford University
2014-2015
Academy of Scientific Research and Technology
2015
Ministry of Higher Education and Scientific Research
2010
Ain Shams University Hospital
2004
Praziquantel (PZQ) is an isoquinoline derivative (2-cyclohexylcarbonyl-1, 2, 3, 6, 7, 11b-hexahydro-4H-pyrazino{2,1-a}-isoquinoline-4-one), and currently the drug of choice for all forms schistosomiasis. Silymarin, a standardized milk thistle extract, which silibinin main component, known its hepatoprotective, anti-inflammatory, antioxidant activities, hepatocyte regeneration. This study investigates anti-inflammatory/anti-fibrotic effects silymarin and/or PZQ on schistosomal hepatic...
Abstract The present study was designed to identify the chemical constituents of methanolic extract Curcuma longa L. rhizomes and their inhibitory effect on a hepatoma cell line. subjected GC-MS analysis volatile other part same liquid column chromatographic separation isolate curcumin. inhibition growth in line cytopathological changes were studied. showed presence fifty compounds C. longa. major ar-turmerone (20.50 %), β-sesquiphellandrene (5.20 %) curcumenol (5.11 %). Curcumin identified...
Ulcerative colitis is a common type of inflammatory bowel disease that affects millions individuals around the world. Traditional UC treatment has focused on suppressing immune responses rather than treating underlying causes UC, which include oxidative stress, inflammation, and microbiota dysbiosis. Diosmin (DIO), naturally occurring flavonoid, possesses antioxidant anti-inflammatory properties. This study aimed to assess efficacy DIO in dextran-sulfate sodium (DSS)-induced colitis,...
Pyridine compounds are one of the most important heterocyclic derivatives showing wide ranges in biological and pharmacological activities. Green chemistry eliminates or reduces generation hazardous compounds. It prevents pollution at a molecular level. The microwave technique used compound synthesis is also an branch green techniques. In this study, we report designing synthesizing new pyridine-bearing pentose moiety via one-pot multicomponent reaction using D-glucose investigate its...
In the past three decades, a significant progress has been made in prevention and treatment of gastric ulcers. The incidence disease decreased, but ulcer is still medical problem. Currently, available drugs for have many side effects; therefore, searching new safe therapeutic agents mandatory. present study aims to investigate gastroprotective potential Cornu aspersum (C. aspersum) mucin against ulcers, mechanisms related oxidative stress inflammation. C. was collected from 50 snails....
Inflammation may activate stem cells via prostaglandin E2 (PGE2) production mediated by cyclooxygenase-2 (COX-2) expression. We performed an immunohistochemical analysis of the expression stemness markers (Oct3/4 and CD44v6) COX-2 in urinary bladder tissues obtained from cystitis cancer patients with without Schistosoma haematobium infections. Immunoreactivity to Oct3/4 was significantly higher S. -associated than normal tissues. CD44v6 located cytoplasmic membrane, cytoplasm, nucleus cells....
Hepatocyte growth factor (HGF) gene transfer inhibits liver fibrosis by regulating aberrant cellular functions, while mutant matrix metalloproteinase-9 (mMMP-9) enhances degradation neutralizing the elevated tissue inhibitor of metalloproteinase-1 (TIMP-1). It was shown that ASH1 and EZH2 methyltransferases are involved in development fibrosis; however, their role resolution phase has not been investigated. This study evaluated two mechanistically different therapeutic modalities, HGF mMMP-9...
The hepatoprotective and antioxidant activity of Bauhinia hookeri ethanol extract (BHE) against CCl4-induced liver injury was investigated in mice. BHE administered (500 1000 mg/kg/day) along with CCl4 for 6 weeks. hepatic marker enzymes: alanine aminotransferase (ALT), aspartate (AST), alkaline phosphatase (ALP) were determined the serum. parameters: glutathione (GSH), superoxide dismutase (SOD), peroxidase (GPx), reductase (GR), transferase (GST), malondialdehyde (MDA) estimated...
Triple-negative breast cancer (TNBC) is an aggressive subtype of that lacks actionable target with limited treatment options beyond conventional chemotherapy. Therapeutic failure often encountered due to inherent or acquired resistance Previous studies implicated PI3K/Akt/mTOR signaling pathway in stem cells (CSCs) enrichment and hence chemoresistance. The present study aimed at investigating the potential effect piperine (PIP), amide alkaloid isolated from Piper nigrum, on enhancing...
Few studies reported the antifibrotic effects of gallic acid (GA) despite its known hepatoprotective and antioxidant activities. Accordingly, this study investigated GA through clarifying mechanisms on hepatic stellate cells' (HSCs) activation, proliferation and/or apoptosis. In vitro HSC-T6 activation/proliferation, morphology safety hepatocytes were assessed. vivo, fibrosis was induced via chronic thioacetamide (TAA)-intoxication. TAA-intoxicated rats treated with silyamrin or GA. At end...
Hibiscus sabdariffa L. (Malvaceae) is a common traditional tea that has many biological activities.To evaluate the hepatoprotective effect and study metabolic profile of anthocyanin-rich extract H. calyces (HSARE).The activity HSARE was assessed (100 mg/kg/d for 4 weeks) by examining hepatic, inflammatory, oxidative stress markers performing histopathological examination in rats with thioacetamide (TAA)-induced hepatotoxicity. analyzed using ultra-performance liquid...
Hepatic schistosomiasis is considered to be one of the most prevalent forms chronic liver disease in world due its complication fibrosis. The demonstration pro-fibrogenic role angiotensin (Ang) II brought up idea that anti-Ang agents may effective improving hepatic fibrosis by either blocking Ang type 1 (AT1) receptors or inhibiting converting enzyme. Peroxisome proliferator-activated gamma (PPARγ) activation has been also shown inhibit stellate cell and progression present study aimed at...
Liver fibrosis is one of the most serious consequences S. mansoni infection. The aim present study was to investigate potential anti-fibrotic effect human Wharton's jelly-derived mesenchymal stem cells (WJMSCs) combined with praziquantel (PZQ) in mansoni-infected mice. mice received early (8(th) week post infection) and late (16(th) treatment WJMSCs, alone oral PZQ. At 10(th) month infection, livers were collected for subsequent flow cytometric, histopathological, morphometric,...
The<italic>lactobacillus casei</italic>and inulin modulate the expression of JNK-1, GSK3β and β-catenin proteins enrich beneficial bacteria to protect from colon cancer in mice.
To design and optimize trans-cinnamic acid-loaded PLGA nanoparticles (CIN-PLGA-NPs) assess its inhibitory effect on epithelial-mesenchymal transition (EMT) in triple-negative breast cancer.The quality by approach was used to correlate the formulation parameters (PLGA amount Poloxamer188 concentration) critical attributes (entrapment efficiency percent, particle size zeta potential). Design of CIN-PLGA-NPs formulations done based central composite response surface formulated nanoprecipitation...