A5028318589- Parasites and Host Interactions
- Parasite Biology and Host Interactions
- Helminth infection and control
- Neuroendocrine regulation and behavior
- Environmental Toxicology and Ecotoxicology
- Fish Biology and Ecology Studies
- Ion Transport and Channel Regulation
- Computational Drug Discovery Methods
- Trace Elements in Health
- Aquatic Ecosystems and Biodiversity
- Pharmaceutical and Antibiotic Environmental Impacts
- Aquatic Ecosystems and Phytoplankton Dynamics
- Water Quality and Pollution Assessment
- Insect Pest Control Strategies
- Marine Sponges and Natural Products
- Neurobiology and Insect Physiology Research
- Bird parasitology and diseases
- Phytochemicals and Medicinal Plants
- Pharmacological Effects of Medicinal Plants
- Parasitic Diseases Research and Treatment
- Environmental and Biological Research in Conflict Zones
- Pomegranate: compositions and health benefits
- Effects and risks of endocrine disrupting chemicals
- Freshwater macroinvertebrate diversity and ecology
- Biological Research and Disease Studies
Theodor Bilharz Research Institute
2016-2025
University of New Mexico
2024
Suez Canal University
2024
National Institute for Parasitic Diseases
2016-2021
The University of Melbourne
2020
Hospital for Tropical Diseases
2018
Ain Shams University
2018
Dalhousie University
2014-2015
Schistosomiasis is one of the world’s most devastating parasitic diseases, afflicting 251 million people globally. The Neotropical snail Biomphalaria glabrata an important intermediate host human blood fluke Schistosoma mansoni and a predominant model for schistosomiasis research. To fully exploit this biomedical research, here we report haplotype-like, chromosome-level assembled annotated genome homozygous iM line B . that developed at University New Mexico. Using multiple sequencing...
Abstract Vitellogenesis is the most important process in animal reproduction, which yolk proteins play a vital role. Among multiple protein precursors, vitellogenin (Vtg) well-known major (MYP) oviparous animals. However, nature of MYP freshwater gastropod snail Biomphalaria glabrata remains elusive. In current study, we applied bioinformatics, tissue-specific transcriptomics, ovotestis-targeted proteomics, and phylogenetics to investigate large lipid transfer (LLTP) superfamily...
ABSTRACT Planorbid snails of the genus Biomphalaria are major intermediate hosts for digenetic trematode parasite Schistosoma mansoni . Evidence suggests that levels neurotransmitter dopamine (DA) reduced during course S. multiplication and transformation within snail. This investigation used immunohistochemical methods to localize tyrosine hydroxylase (TH), rate‐limiting enzyme in biosynthesis catecholamines, nervous system The two species examined, glabrata alexandrina , sub‐Saharan...
The emerging evolution of antibiotic and anthelmintic resistance inefficiency some synthetic drugs elicit the need to investigate new drug sources. In this context, Eucalyptus camaldulensis is an evergreen tree that has been widely used in traditional medicine for treatment various health disorders. Organic solvent extracts from leaves were assessed their antimicrobial activity. Among these extracts, ethyl acetate (EtOAc) water showed highest activity against Staphylococcus aureus,...
Control of snail intermediate hosts has been proved to be a fast and efficient approach for interrupting the transmission schistosomiasis. Some plant extracts have shown obvious molluscicidal activity, new compound Luo-Wei, also named tea-seed distilled saponin (TDS), was developed based on saponins extracted from Camellia oleifera seeds. We aimed test activity 4% TDS against host snails in China Egypt, evaluate its environmental safety non-target organisms.In laboratory, Oncomelania...
The simpler nervous systems of certain invertebrates provide opportunities to examine colocalized classical neurotransmitters in the context identified neurons and well defined neural circuits. This study examined distribution γ-aminobutyric acid-like immunoreactivity (GABAli) system panpulmonates Biomphalaria glabrata alexandrina, major intermediate hosts for intestinal schistosomiasis. GABAli were localized cerebral, pedal, buccal ganglia each species. With exception a projection base...
Schistosomiasis is a common parasitic disease designated as neglected tropical by the World Health Organization. mansoni form of that caused digenean trematode Schistosoma mansoni, transmitted through Biomphalaria spp. an intermediate host. was introduced to Hong Kong, China in aquatic plants shipments coming from Brazil and snail rapidly established its habitats southern China. Earlier studies identified snails straminea, one susceptible species implicated S. transmission South America....
The Acid Sensing Ion Channel 3 (ASIC3) is a non-selective cation channel that activated by acidification, and known to have role in regulating inflammatory pain. It has pro-algesic roles range of conditions present with bone pain, but the mechanism for this not yet been demonstrated. We aimed determine if ASIC3 expressed Aδ and/or C fiber afferent neurons, explore its activation sensitization neurons after acute inflammation. A combination retrograde tracing immunohistochemistry was used...
Schistosomiasis is one of the most prevalent parasitic diseases impacting human health in tropics and sub-tropics. The geographic distribution Schistosoma mansoni, widespread species, includes areas Africa, Middle East, South America Caribbean. Snails genus Biomphalaria act as intermediate host for S. mansoni. straminea not indigenous China but was accidentally introduced to Hong Kong from has spread other habitats southern parts country. This species known its great dispersal capacity that...
Histamine appears to be an important transmitter throughout the Animal Kingdom. Gastropods, in particular, have been used numerous studies establishing potential roles for this biogenic amine nervous system and showing its involvement generation of diverse behaviours. And yet, distribution histamine has only previously described a small number molluscan species. The present study examined localization histamine-like immunoreactivity central peripheral systems pulmonate snails genus...
In the present study, Biomphalaria snails collected from five Egyptian governorates (Giza, Fayoum, Kafr El-Sheikh, Ismailia and Damietta), as well reference control alexandrina Schistosome Biological Supply Center (SBSC) (Theodor Bilharz Research Institute, Egypt), were subjected to species-specific polymerase chain reaction (PCR) assays identify species. All of found be B. there was no evidence presence glabrata. Randomly amplified polymorphic DNA (RAPD)-PCR showed different fingerprints...
Globally, more than 200 million people live at risk of the neglected tropical disease schistosomiasis (or snail fever). Larval schistosomes require presence specific species that act as intermediate hosts, supporting their multiplication and transformation into forms can infect humans. This project was designed to generate a transcriptome from central nervous system (CNS) Biomphalaria alexandrina, major host for Schistosoma mansoni in Egypt. A generated five pooled systems dissected...
Cytotoxicity Studies of Xanthorrhizol and Its Mechanism Using Molecular Docking Simulation Pharmacophore ModellingIda Musfiroh, Muchtaridi Muchtaridi, Ahmad Muhtadi, Ajeng Diantini, Aliya Nur Hasanah, Linar Zalinar Udin, Yasmiwar Susilawati, Resmi Mustarichie, Rahmana E Kartasasmita, Slamet Ibrahim
Thais savignyi Deshayes (Muricidae) is widely distributed in the Red Sea. Its abundance and history of Muricidae traditional medicine make it a tempting target for investigation.To investigate chemical profile biological activities T. tissue extracts.Methanol, ethanol, acetone, ethyl acetate extracts from were compared their antioxidant by total capacity, DPPH free radical scavenging, phenolic content. In addition, antimicrobial, antibiofilm properties (at 250 µg/mL) tested against...
The transmission of some schistosome parasites is dependent on the planorbid snail hosts. Bulinus truncatus important in urinary schistosomiasis epidemiology Africa. Hence, there a need to define snails’ phylogeography. This study assessed population genetic structure B. from Giza and Sharkia (Egypt), Barakat (Sudan) Madziwa, Shamva District (Zimbabwe) using mitochondrial cytochrome oxidase subunit 1 gene (COI) internal transcribed spacer (ITS 1) markers. COI was sequenced 94 samples...
ABSTRACTObjective: To evaluate the antioxidant activity and chemical composition of Punica granatum L. test it as immunostimulants against Schistosomamansoni infection to Biomphalaria alexandrina snails.Methods: Antioxidant was evaluated by measuring free radical scavenging 90% defatted methanol extract (90% DM)of P. peels its sub-derived fractions via 2,2’-diphenyl-1-picrylhydrazyl constituents were identified viagas chromatography-mass spectrometry (GC-MS) analysis. B. snails exposed...
Abstract Background Snail intermediate hosts are mandatory for the transmission of schistosomiasis, which has to date infected more than 200 million people worldwide. Our previous studies showed that niclosamide treatment caused inhibition aerobic respiration and oxidative phosphorylation, disruption energy supply, in one Oncomelania hupensis , eventually led death snails. Meanwhile, terminal oxidase mitochondrial respiratory chain, alternative (AOX), was significantly up-regulated, thought...