A5034883673- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Biomedical Text Mining and Ontologies
- Renal Transplantation Outcomes and Treatments
- Immunotherapy and Immune Responses
- Recommender Systems and Techniques
- Intelligent Tutoring Systems and Adaptive Learning
- Health Education and Validation
- Immune Response and Inflammation
- Cancer, Hypoxia, and Metabolism
- Traditional Chinese Medicine Studies
- Acute Kidney Injury Research
- Complementary and Alternative Medicine Studies
- RNA modifications and cancer
- Topic Modeling
- Health Literacy and Information Accessibility
- Nigella sativa pharmacological applications
- Traditional Chinese Medicine Analysis
- linguistics and terminology studies
- Chemotherapy-induced organ toxicity mitigation
- Data Quality and Management
- IL-33, ST2, and ILC Pathways
- Erythropoietin and Anemia Treatment
- Online Learning and Analytics
- Quality and Safety in Healthcare
Hangzhou Medical College
2018-2025
Zhejiang Provincial People's Hospital
2018-2025
Guangzhou University of Chinese Medicine
2014-2017
The Seventh Affiliated Hospital of Sun Yat-sen University
2017
Sun Yat-sen University
2017
Mayo Clinic in Florida
2017
Mayo Clinic
2016-2017
Guangdong Provincial Hospital of Traditional Chinese Medicine
2014
// Yu-Qun Zeng 1,* , Zhenhua Dai 2,* Fuhua Lu 1 Zhaoyu Xusheng Liu Cha Chen 3 Pinghua Qu Dingcheng Li 4 Zhengshuang Hua 5 Yanni and Chuan Zou Department of Nephrology, The Second Clinical College, Guangzhou University Chinese Medicine Guangdong Provincial Academy Medical Sciences, Guangzhou, Guangdong, P.R. China 2 Section Immunology, Laboratory Medicine, Biomedical Statistics Informatics, Mayo Clinic, Rochester, MN, United States America State Key Biocontrol, Biodiversity Dynamics...
Maintenance immunosuppression is required for suppression of alloimmunity or allograft rejection. However, continuous use immunosuppressants may lead to various side effects, necessitating the alternative immunosuppressive drugs. The early secreted antigenic target 6 kDa (ESAT-6) a virulence factor and immunoregulatory protein mycobacterium tuberculosis (Mtb), which alters host immunity through dually regulating development activation immune cells. ESAT-6 be potential immunosuppressant that...
Aim To investigate the effects of rhubarb enema treatment using a 5/6 nephrectomized rat model and study its mechanisms. Methods Twenty-eight Sprague Dawley rats were divided into three groups: sham operation group (n = 8), (5/6Nx) 10), 5/6Nx with 10). The was continuous for 1.0 month. Serum creatinine, serum indoxyl sulfate (IS) level, renal pathology, tubulointerstitial fibrosis, oxidative stress assessed. Results showed increasing levels creatinine severe pathological lesions. Their...
// Huazhen Liu 1 , Yeshu Wang 2 Qiaohuang Zeng Yu-Qun 2,3 Chun-Ling Liang Feifei Qiu Hong Nie 4 and Zhenhua Dai Section of Immunology, Guangdong Provincial Academy Chinese Medical Sciences, Hospital Medicine, Guangzhou, Guangdong, P.R. China Graduate School, Guangzhou University 3 Student Exchange Program, Mayo Clinic, Rochester, MN, USA Key Laboratory Pharmacodynamic Constituents TCM New Drugs Research, College Pharmacy, Jinan University, Correspondence to: Dai, email: Keywords :...
Objective: To investigate the effects of grape seed proanthocyanidin extract (GSPE) on indoxyl sulfate-induced Human Umbilical Vein Endothelial Cells (HUVECs) injury in vitro and study its mechanism. Methods: HUVECs were incubated with sulfate at concentrations range found uremic patients. Then we determined effect endothelial phenotype, function, ROS (reactive oxygen species), cell apoptosis mitochondrial function. In addition, detected whether GSPE can suppress induced by probe mechanism...
Calcineurin inhibitor cyclosporine is widely used as an immunosuppressant in clinic. However, mounting evidence has shown that hinders tolerance induction by dampening Tregs. Therefore, it of paramount importance to overcome this pitfall. Kaempferol was reported inhibit DC function. Here, we found kaempferol delayed islet allograft rejection. Combination and low-dose, but not high-dose, induced majority recipient mice. Although plus either dose largely abrogated proliferation...
Self-management is crucial to diabetes care and providing expert-vetted content for answering patients' questions in facilitating patient self-management.The aim investigate the use of information retrieval techniques recommending education materials diabetic patients.We compared two algorithms, one based on Latent Dirichlet Allocation topic modeling (topic modeling-based model) semantic group (semantic group-based model), with baseline models, vector space model (VSM), posted TuDiabetes...
Accurate quantitative analysis of trace analytes in a complicated matrix is challenge modern analytical chemistry. An appropriate method considered to be one the most common gaps during whole process. In this study, green and efficient strategy based on miniaturized solid-phase dispersion extraction combined with capillary electrophoresis was first proposed for extracting, purifying determining target from matrix, using Wubi Shanyao Pill as an example. detail, 60 mg samples were dispersed...
Over the past few decades, significant progress has been made in development of drugs to combat cancer. It is unfortunate that these can also lead various kidney injuries and imbalances electrolyte levels. Nephrotoxicity caused by chemotherapy impact different parts kidneys, including glomeruli, renal tubules, interstitium, or microvessels. Despite existing knowledge, our understanding mechanisms underlying damage antitumoral remains incomplete. In this review, we aim provide a comprehensive...
// Xusheng Liu 1,* , Yu-Qun Zeng Yong-Zhuo Liang 2,* Chuan Zou Huazhen 3,* Feifei Qiu 3 Chun-Lin Xiao-Wei Jin Zi-Ren Su 2 and Zhenhua Dai 1,3 1 Department of Nephrology, the Second Clinical College, Guangzhou University Chinese Medicine, Guangzhou, Guangdong, P.R. China School Materia Medica, Section Immunology, Guangdong Provincial Academy Medical Sciences, * These authors have contributed equally to this study Correspondence to: Dai, email: Keywords : T cells, immunosuppression, herbs...
What is known and objective Patients with kidney disease receiving immunosuppressive drugs (ISDs) (tacrolimus, cyclosporine glucocorticoids) have a high risk of developing new-onset diabetes mellitus (NODM). We aimed to establish precise convenient model for predicting NODM in patients drugs. Methods This retrospective study recruited 1883 ISDs between January 2010 October 2018. The occurrence was the primary endpoint. were randomly divided into training (n = 1318) validation cohorts 565) at...
As an increasing number of patients seek medical information online, it is crucial to bring expert-vetted patients. Multiple online resources exist for their accuracy and authority knowledge. However, not clear which resource better in meeting the needs Utilizing a collection questions raised by with diabetes retrieved from forum, we manually evaluated three widely used (WebMD, MedlinePlus, UpToDate) terms content coverage time spent find answers. The results indicated that WebMD had...